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Record Information
Version1.0
Creation Date2016-09-30 22:18:55 UTC
Update Date2020-05-21 16:29:28 UTC
BMDB IDBMDB0000045
Secondary Accession Numbers
  • BMDB00045
Metabolite Identification
Common NameAdenosine monophosphate
DescriptionAdenosine monophosphate, also known as adenylic acid or AMP, belongs to the class of organic compounds known as purine ribonucleoside monophosphates. These are nucleotides consisting of a purine base linked to a ribose to which one monophosphate group is attached. Adenosine monophosphate is a drug which is used for nutritional supplementation, also for treating dietary shortage or imbalance. Adenosine monophosphate exists as a solid, possibly soluble (in water), and a strong basic compound (based on its pKa) molecule. Adenosine monophosphate exists in all living species, ranging from bacteria to humans.
Structure
Thumb
Synonyms
ValueSource
5'-Adenosine monophosphateChEBI
5'-Adenylic acidChEBI
5'-AMPChEBI
5'-O-PhosphonoadenosineChEBI
Adenosine 5'-(dihydrogen phosphate)ChEBI
Adenosine 5'-phosphateChEBI
Adenosine phosphateChEBI
Adenosine-5'-monophosphoric acidChEBI
Adenosine-5'pChEBI
Adenosini phosphasChEBI
AdenylateChEBI
Adenylic acidChEBI
Ado5'pChEBI
AMPChEBI
Fosfato de adenosinaChEBI
pAChEBI
PAdoChEBI
Phosphate d'adenosineChEBI
Adenosine 5'-monophosphateKegg
AdenylKegg
5'-Adenosine monophosphoric acidGenerator
5'-AdenylateGenerator
Adenosine 5'-(dihydrogen phosphoric acid)Generator
Adenosine 5'-phosphoric acidGenerator
Adenosine phosphoric acidGenerator
Adenosine-5'-monophosphateGenerator
Phosphoric acid d'adenosineGenerator
Adenosine 5'-monophosphoric acidGenerator
Adenosine monophosphoric acidGenerator
Adenosine 5'-phosphorateHMDB
Adenosine-5'-monophosphorateHMDB
Adenosine-5-monophosphorateHMDB
Adenosine-5-monophosphoric acidHMDB
Adenosine-monophosphateHMDB
Adenosine-phosphateHMDB
AdenoviteHMDB
CardiomoneHMDB
LycedanHMDB
Muscle adenylateHMDB
Muscle adenylic acidHMDB
My-b-denHMDB
My-beta-denHMDB
PhosadenHMDB
PhosphadenHMDB
PhosphentasideHMDB
5'-Phosphate, adenosineHMDB
Acid, 2'-adenylicHMDB
2'-Adenylic acidHMDB
Adenosine 3' phosphateHMDB
Disodium, adenosine phosphateHMDB
Phosphate dipotassium, adenosineHMDB
Adenosine 2'-phosphateHMDB
Adenosine 5' phosphateHMDB
Adenosine phosphate dipotassiumHMDB
Dipotassium, adenosine phosphateHMDB
2' Adenylic acidHMDB
5' Adenylic acidHMDB
Acid, 5'-adenylicHMDB
Adenosine 3'-phosphateHMDB
monoPhosphate, 2'-adenosineHMDB
Phosphate disodium, adenosineHMDB
2' Adenosine monophosphateHMDB
2'-AMPHMDB
2'-Adenosine monophosphateHMDB
Adenosine 2' phosphateHMDB
Adenosine phosphate disodiumHMDB
Chemical FormulaC10H14N5O7P
Average Molecular Weight347.2212
Monoisotopic Molecular Weight347.063084339
IUPAC Name{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid
Traditional Nameadenylate
CAS Registry Number61-19-8
SMILES
NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1
InChI Identifier
InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChI KeyUDMBCSSLTHHNCD-KQYNXXCUSA-N
Chemical Taxonomy
Description belongs to the class of organic compounds known as purine ribonucleoside monophosphates. These are nucleotides consisting of a purine base linked to a ribose to which one monophosphate group is attached.
KingdomOrganic compounds
Super ClassNucleosides, nucleotides, and analogues
ClassPurine nucleotides
Sub ClassPurine ribonucleotides
Direct ParentPurine ribonucleoside monophosphates
Alternative Parents
Substituents
  • Purine ribonucleoside monophosphate
  • Pentose phosphate
  • Pentose-5-phosphate
  • Glycosyl compound
  • N-glycosyl compound
  • 6-aminopurine
  • Monosaccharide phosphate
  • Pentose monosaccharide
  • Imidazopyrimidine
  • Purine
  • Aminopyrimidine
  • Monoalkyl phosphate
  • Alkyl phosphate
  • Monosaccharide
  • Pyrimidine
  • Imidolactam
  • N-substituted imidazole
  • Organic phosphoric acid derivative
  • Phosphoric acid ester
  • Tetrahydrofuran
  • Azole
  • Imidazole
  • Heteroaromatic compound
  • Secondary alcohol
  • 1,2-diol
  • Organoheterocyclic compound
  • Oxacycle
  • Azacycle
  • Organonitrogen compound
  • Primary amine
  • Hydrocarbon derivative
  • Organic oxide
  • Alcohol
  • Organopnictogen compound
  • Organic oxygen compound
  • Organic nitrogen compound
  • Organooxygen compound
  • Amine
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Ontology
StatusDetected and Quantified
Origin
  • Endogenous
  • Exogenous
BiofunctionNot Available
ApplicationNot Available
Cellular locations
  • Cytoplasm
  • Endoplasmic reticulum
  • Golgi
  • Lysosome
  • Mitochondria
  • Nucleus
  • Peroxisome
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point195 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility10 mg/mL at 20 °CBEILSTEIN
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP-3.1ALOGPS
logP-4.7ChemAxon
logS-2ALOGPS
pKa (Strongest Acidic)1.22ChemAxon
pKa (Strongest Basic)3.92ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count10ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area186.07 ŲChemAxon
Rotatable Bond Count4ChemAxon
Refractivity74.07 m³·mol⁻¹ChemAxon
Polarizability29.96 ųChemAxon
Number of Rings3ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash Key
GC-MSGC-MS Spectrum - GC-MS (5 TMS)splash10-014i-0974000000-7ce25c09f93913b81e9bView in MoNA
GC-MSGC-MS Spectrum - GC-MS (4 TMS)splash10-014i-0975000000-8175538459abaf92d36fView in MoNA
GC-MSGC-MS Spectrum - GC-MS (Non-derivatized)splash10-014i-0974000000-7ce25c09f93913b81e9bView in MoNA
GC-MSGC-MS Spectrum - GC-MS (Non-derivatized)splash10-014i-0975000000-8175538459abaf92d36fView in MoNA
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positivesplash10-002b-9713000000-019182f931e395f479cdView in MoNA
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (2 TMS) - 70eV, Positivesplash10-0gl0-4942400000-fb8ced86745a4de1b047View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-052b-0209001000-f6c3cf706bb3b839d180View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-053s-0395300000-e2a342872025e6e960aeView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-000i-0900000000-2b9fb262817de641a5cdView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-053r-0007920000-ee7bab39079e225a1b07View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-0002-0109000000-52331e416cbdd8218b97View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-014i-3900000000-ddc799b6e2bb5d5ac9a6View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-000i-0900000000-68d6660e0cfbfb8f02adView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-000i-0900000000-27f73c3a0a9566986a0eView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-03dm-0007009001-639c5cafae90b10dfc5fView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-03di-0290000000-e0b5612abd24736e70daView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-0a4i-0039210000-3e5b716531d739ca25d9View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-0002-0009000000-9232b7438abb1f6256b6View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-0007-2109007000-3e1cf347bd9e054b9368View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-0006-0002009000-b840e6edcca65562937bView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-03di-0190000000-948ec97ae442eda212cbView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-0002-0009000000-bd1c10704f289141803aView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positivesplash10-0002-0109000000-433eab5bd833cd92f290View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) 30V, Positivesplash10-000b-0709000000-fa268a51905a453bc6f5View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negativesplash10-002b-9104000000-bc358c1d8c03290fc49dView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-000i-0913000000-52bfdec6ec6f2f9422f4View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-000i-0900000000-9bf867ba72f77732e0ceView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-000i-1900000000-fab6495d31eac8de123cView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0032-6709000000-fd9ea223f556b17d2d3aView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0059-8900000000-3937203187746280b10aView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-004i-9200000000-5947ff2a364087cb0e38View in MoNA
1D NMR1H NMR SpectrumNot AvailableView in JSpectraViewer
2D NMR[1H,1H] 2D NMR SpectrumNot AvailableView in JSpectraViewer
2D NMR[1H,13C] 2D NMR SpectrumNot AvailableView in JSpectraViewer
Biological Properties
Cellular Locations
  • Cytoplasm
  • Endoplasmic reticulum
  • Golgi
  • Lysosome
  • Mitochondria
  • Nucleus
  • Peroxisome
Biospecimen Locations
  • All Tissues
  • Liver
  • Mammary Gland
  • Milk
  • Placenta
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
All TissuesExpected but not QuantifiedNot ApplicableNot SpecifiedNot SpecifiedNormal
  • Not Applicable
details
LiverDetected but not QuantifiedNot ApplicableNot SpecifiedNot Specified
Normal
details
LiverDetected but not QuantifiedNot ApplicableNot SpecifiedNot Specified
Normal
details
LiverDetected but not QuantifiedNot ApplicableNot SpecifiedNot Specified
Normal
details
Mammary GlandDetected but not QuantifiedNot ApplicableNot SpecifiedNot Specified
Normal
details
Mammary GlandDetected but not QuantifiedNot ApplicableNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified15.800 - 80.300 uMNot SpecifiedNot SpecifiedNormal details
MilkDetected but not QuantifiedNot ApplicableNot SpecifiedNot Specified
Normal
    • Kurt J. Boudonck,...
details
MilkDetected but not QuantifiedNot ApplicableNot SpecifiedNot Specified
Normal
details
PlacentaExpected but not QuantifiedNot ApplicableNot SpecifiedNot SpecifiedNormal
  • Not Applicable
details
Abnormal Concentrations
Not Available
HMDB IDHMDB0000045
DrugBank IDDB00131
Phenol Explorer Compound IDNot Available
FooDB IDFDB030677
KNApSAcK IDC00019347
Chemspider ID5858
KEGG Compound IDC00020
BioCyc IDAMP
BiGG ID33534
Wikipedia LinkAdenylic_acid
METLIN ID5111
PubChem Compound6083
PDB IDNot Available
ChEBI ID16027
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Gil A, Sanchez-Medina F: Acid-soluble nucleotides of cow's, goat's and sheep's milks, at different stages of lactation. J Dairy Res. 1981 Feb;48(1):35-44. [PubMed:7196410 ]
  2. Melzer N, Wittenburg D, Hartwig S, Jakubowski S, Kesting U, Willmitzer L, Lisec J, Reinsch N, Repsilber D: Investigating associations between milk metabolite profiles and milk traits of Holstein cows. J Dairy Sci. 2013 Mar;96(3):1521-34. doi: 10.3168/jds.2012-5743. [PubMed:23438684 ]
  3. Kurt J. Boudonck, Matthew W. Mitchell, Jacob Wulff and John A. Ryals (2009). Kurt J. Boudonck, Matthew W. Mitchell, Jacob Wulff and John A. Ryals. Characterization of the biochemical variability of bovine milk using metabolomics. Metabolomics (2009) 5:375?386. Metabolomics.

Only showing the first 50 proteins. There are 67 proteins in total.

Enzymes

General function:
Translation, ribosomal structure and biogenesis
Specific function:
Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
Gene Name:
SARS2
Uniprot ID:
Q9N0F3
Molecular weight:
58296.0
Reactions
L-Serine + Adenosine triphosphate + L-Seryl-tRNA → Adenosine monophosphate + L-Seryl-tRNA(Ser) + Pyrophosphatedetails
General function:
Translation, ribosomal structure and biogenesis
Specific function:
Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA.
Gene Name:
SARS1
Uniprot ID:
Q9GMB8
Molecular weight:
58605.0
Reactions
L-Serine + Adenosine triphosphate + L-Seryl-tRNA → Adenosine monophosphate + L-Seryl-tRNA(Ser) + Pyrophosphatedetails
General function:
Nucleotide transport and metabolism
Specific function:
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
Gene Name:
APRT
Uniprot ID:
Q56JW4
Molecular weight:
19537.0
Reactions
Adenosine monophosphate + Pyrophosphate → Adenine + Phosphoribosyl pyrophosphatedetails
General function:
Carbohydrate transport and metabolism
Specific function:
Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6 (By similarity).
Gene Name:
BPNT1
Uniprot ID:
Q3ZCK3
Molecular weight:
33328.0
General function:
Nucleotide transport and metabolism
Specific function:
One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues.
Gene Name:
ASS1
Uniprot ID:
P14568
Molecular weight:
46417.0
Reactions
Adenosine triphosphate + Citrulline + L-Aspartic acid → Adenosine monophosphate + Pyrophosphate + Argininosuccinic aciddetails
General function:
Lipid transport and metabolism
Specific function:
Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (By similarity). Propionate is the preferred substrate but can also utilize acetate and butyrate with a much lower affinity.
Gene Name:
ACSS3
Uniprot ID:
A7MB45
Molecular weight:
74805.0
Reactions
Propinol adenylate + Adenosine triphosphate + Pantetheine → Propionyl-CoA + Adenosine monophosphate + Pyrophosphatedetails
Propinol adenylate → Propionic acid + Adenosine monophosphatedetails
Caproic acid + Adenosine triphosphate + Coenzyme A → Hexanoyl-CoA + Adenosine monophosphate + Pyrophosphatedetails
General function:
Translation, ribosomal structure and biogenesis
Specific function:
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage.
Gene Name:
TARS1
Uniprot ID:
Q3ZBV8
Molecular weight:
83492.0
Reactions
Adenosine triphosphate + L-Threonine + tRNA(Thr) → Adenosine monophosphate + Pyrophosphate + L-Threonyl-tRNA(Thr)details
General function:
Involved in magnesium ion binding
Specific function:
3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (By similarity). Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails (By similarity) (PubMed:10698948, PubMed:9736620). Also able to recognize poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to microRNAs degradation or snoRNA increased stability (By similarity).
Gene Name:
PARN
Uniprot ID:
P69341
Molecular weight:
73182.0
General function:
Nucleotide transport and metabolism
Specific function:
Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
Gene Name:
PRPS1
Uniprot ID:
Q2HJ58
Molecular weight:
34834.0
Reactions
D-Ribose 5-phosphate + Adenosine triphosphate → Phosphoribosyl pyrophosphate + Adenosine monophosphatedetails
General function:
Lipid transport and metabolism
Specific function:
Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:11382754, PubMed:10561077). Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate (PubMed:10561077, PubMed:11382754). Also catalyzes the activation of lipoate to lipoyl-nucleoside monophosphate (PubMed:11382754). Activates lipoate with GTP at a 1000-fold higher rate than with ATP and activates both (R)- and (S)-lipoate to the respective lipoyl-GMP, with a preference for (R)-lipoate (PubMed:11382754).
Gene Name:
ACSM1
Uniprot ID:
Q9BEA2
Molecular weight:
64923.0
Reactions
Dodecanoic acid + Adenosine triphosphate + Coenzyme A → Lauroyl-CoA + Adenosine monophosphate + Pyrophosphatedetails
General function:
Replication, recombination and repair
Specific function:
Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle.
Gene Name:
NUDT12
Uniprot ID:
Q29RH3
Molecular weight:
50119.0
Reactions
NAD + Water → Nicotinamide ribotide + Adenosine monophosphatedetails
Nicotinic acid adenine dinucleotide + Water → Nicotinic acid mononucleotide + Adenosine monophosphatedetails
General function:
Translation, ribosomal structure and biogenesis
Specific function:
Not Available
Gene Name:
RARS2
Uniprot ID:
Q0P5H7
Molecular weight:
65631.0
Reactions
Adenosine triphosphate + L-Arginine + tRNA(Arg) → Adenosine monophosphate + Pyrophosphate + L-Arginyl-tRNA(Arg)details
General function:
Amino acid transport and metabolism
Specific function:
Not Available
Gene Name:
ASNS
Uniprot ID:
Q1LZA3
Molecular weight:
64220.0
Reactions
Adenosine triphosphate + L-Aspartic acid + L-Glutamine + Water → Adenosine monophosphate + Pyrophosphate + L-Asparagine + L-Glutamic aciddetails
General function:
Translation, ribosomal structure and biogenesis
Specific function:
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.
Gene Name:
DARS1
Uniprot ID:
Q3SYZ4
Molecular weight:
57036.0
Reactions
Adenosine triphosphate + L-Aspartic acid + tRNA(Asp) → Adenosine monophosphate + Pyrophosphate + L-Aspartyl-tRNA(Asp)details
General function:
Nucleotide transport and metabolism
Specific function:
Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.
Gene Name:
AK3
Uniprot ID:
P08760
Molecular weight:
25671.0
General function:
Amino acid transport and metabolism
Specific function:
Synthesizes selenophosphate from selenide and ATP.
Gene Name:
SEPHS1
Uniprot ID:
Q0VC82
Molecular weight:
42881.0
Reactions
Adenosine triphosphate + Hydrogen selenide + Water → Adenosine monophosphate + Phosphoroselenoic acid + Hydrogen phosphatedetails
General function:
Translation, ribosomal structure and biogenesis
Specific function:
Not Available
Gene Name:
CARS2
Uniprot ID:
Q2KIF8
Molecular weight:
61199.0
Reactions
Adenosine triphosphate + L-Cysteine + tRNA(Cys) → Adenosine monophosphate + Pyrophosphate + L-Cysteinyl-tRNA(Cys)details
General function:
Translation, ribosomal structure and biogenesis
Specific function:
Not Available
Gene Name:
NARS
Uniprot ID:
Q2KJG3
Molecular weight:
64399.0
Reactions
Adenosine triphosphate + L-Asparagine + tRNA(Asn) → Adenosine monophosphate + Pyrophosphate + L-Asparaginyl-tRNA(Asn)details
General function:
Coenzyme transport and metabolism
Specific function:
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
Gene Name:
NADSYN1
Uniprot ID:
Q3ZBF0
Molecular weight:
79400.0
Reactions
Nicotinic acid adenine dinucleotide + Adenosine triphosphate + Water + L-Glutamine → NAD + Adenosine monophosphate + Pyrophosphate + L-Glutamic aciddetails
General function:
Translation, ribosomal structure and biogenesis
Specific function:
Glutamine--tRNA ligase. Plays a critical role in brain development.
Gene Name:
QARS1
Uniprot ID:
Q3MHH4
Molecular weight:
87643.0
Reactions
L-Glutamine + Adenosine triphosphate + tRNA(Gln) → Adenosine monophosphate + Pyrophosphate + L-Glutaminyl-tRNA(Gln)details
General function:
Translation, ribosomal structure and biogenesis
Specific function:
T1-TrpRS has aminoacylation activity while T2-TrpRS lacks it. T1-TrpRS and T2-TrpRS possess angiostatic activity. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression (By similarity).
Gene Name:
WARS1
Uniprot ID:
P17248
Molecular weight:
53812.0
Reactions
Adenosine triphosphate + L-Tryptophan + tRNA(Trp) → Adenosine monophosphate + Pyrophosphate + L-Tryptophyl-tRNA(Trp)details
General function:
Translation, ribosomal structure and biogenesis
Specific function:
Mitochondrial aminoacyl-tRNA synthetase that activate and transfer the amino acids to their corresponding tRNAs during the translation of mitochondrial genes and protein synthesis.
Gene Name:
WARS2
Uniprot ID:
Q3T099
Molecular weight:
40205.0
Reactions
Adenosine triphosphate + L-Tryptophan + tRNA(Trp) → Adenosine monophosphate + Pyrophosphate + L-Tryptophyl-tRNA(Trp)details
General function:
Nucleotide transport and metabolism
Specific function:
Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.
Gene Name:
ADSL
Uniprot ID:
A3KN12
Molecular weight:
55484.0
Reactions
Adenylsuccinic acid → Fumaric acid + Adenosine monophosphatedetails
General function:
Translation, ribosomal structure and biogenesis
Specific function:
Not Available
Gene Name:
KARS
Uniprot ID:
Q3T0N2
Molecular weight:
71321.0
Reactions
Adenosine triphosphate + L-Lysine + tRNA(Lys) → Adenosine monophosphate + Pyrophosphate + L-Lysyl-tRNA(Lys)details
General function:
Coenzyme transport and metabolism
Specific function:
Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate (By similarity).
Gene Name:
TPK1
Uniprot ID:
Q5E9T4
Molecular weight:
27028.0
Reactions
Adenosine triphosphate + Thiamine → Adenosine monophosphate + Thiamine pyrophosphatedetails
General function:
Lipid transport and metabolism
Specific function:
Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids.
Gene Name:
ACSBG1
Uniprot ID:
Q2KHW5
Molecular weight:
80585.0
Reactions
Palmitic acid + Adenosine triphosphate + Coenzyme A → Palmityl-CoA + Adenosine monophosphate + Pyrophosphatedetails
Stearic acid + Coenzyme A + Adenosine triphosphate → Stearoyl-CoA + Pyrophosphate + Adenosine monophosphatedetails
General function:
Translation, ribosomal structure and biogenesis
Specific function:
Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Plays a role in axon guidance.
Gene Name:
HARS1
Uniprot ID:
Q2KI84
Molecular weight:
57285.0
Reactions
Adenosine triphosphate + L-Histidine + tRNA(His) → Adenosine monophosphate + Pyrophosphate + L-Histidyl-tRNA(His)details
General function:
Translation, ribosomal structure and biogenesis
Specific function:
Mitochondrial aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP).
Gene Name:
HARS2
Uniprot ID:
A5D7V9
Molecular weight:
56914.0
Reactions
Adenosine triphosphate + L-Histidine + tRNA(His) → Adenosine monophosphate + Pyrophosphate + L-Histidyl-tRNA(His)details
General function:
Nucleotide transport and metabolism
Specific function:
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
Gene Name:
AK1
Uniprot ID:
P00570
Molecular weight:
21664.0
Reactions
Adenosine triphosphate + Adenosine monophosphate →2 ADPdetails
General function:
Translation, ribosomal structure and biogenesis
Specific function:
Not Available
Gene Name:
MARS2
Uniprot ID:
A6H7E1
Molecular weight:
66648.0
Reactions
L-Methionine + Adenosine triphosphate + tRNA(Met) → L-Methionyl-tRNA(Met) + Adenosine monophosphate + Pyrophosphatedetails
General function:
Translation, ribosomal structure and biogenesis
Specific function:
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Plays a role in the synthesis of ribosomal RNA in the nucleolus.
Gene Name:
MARS1
Uniprot ID:
Q2T9L8
Molecular weight:
100634.0
Reactions
Selenomethionine + Adenosine triphosphate + tRNA(Met) → Selenomethionyl-tRNA(Met) + Adenosine monophosphate + Pyrophosphatedetails
L-Methionine + Adenosine triphosphate + tRNA(Met) → L-Methionyl-tRNA(Met) + Adenosine monophosphate + Pyrophosphatedetails
General function:
Involved in G-protein coupled receptor protein signalin
Specific function:
Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity).
Gene Name:
PTGDR
Uniprot ID:
A5D7K8
Molecular weight:
40372.0
General function:
Involved in G-protein coupled receptor activity
Specific function:
Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.
Gene Name:
PTGIR
Uniprot ID:
P79393
Molecular weight:
41247.0
General function:
Involved in prostaglandin E receptor activity
Specific function:
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function (By similarity).
Gene Name:
PTGER4
Uniprot ID:
Q8MJ08
Molecular weight:
53298.0
General function:
Not Available
Specific function:
Receptor for prostaglandin E2 (PGE2) (PubMed:8396726). The various isoforms have identical ligand binding properties but interact with different second messenger systems: isoform EP3A couples to G(i)/G(o) proteins; isoform EP3B and isoform EP3C couple to G(s), and isoform EP3D couples to G(i), G(s) and G(p) (PubMed:8396726). Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration. Not required for normal kidney function, normal urine volume and osmolality (By similarity).
Gene Name:
PTGER3
Uniprot ID:
P34979
Molecular weight:
46362.0
General function:
Involved in vasopressin receptor activity
Specific function:
Receptor for arginine vasopressin (PubMed:7698346, PubMed:8257689). The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption (By similarity).
Gene Name:
AVPR2
Uniprot ID:
P48044
Molecular weight:
40236.0
General function:
Translation, ribosomal structure and biogenesis
Specific function:
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
Gene Name:
AARS1
Uniprot ID:
A6QLT9
Molecular weight:
106655.0
Reactions
Adenosine triphosphate + L-Alanine + tRNA(Ala) → Adenosine monophosphate + Pyrophosphate + L-Alanyl-tRNA(Ala)details
General function:
Involved in melanocyte stimulating hormone receptor act
Specific function:
Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Could be involved in spermatogenesis.
Gene Name:
MC1R
Uniprot ID:
P47798
Molecular weight:
34916.0
General function:
Involved in vasoactive intestinal polypeptide receptor
Specific function:
This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract (By similarity).
Gene Name:
ADCYAP1R1
Uniprot ID:
Q29627
Molecular weight:
58785.0
General function:
Involved in alpha2-adrenergic receptor activity
Specific function:
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity).
Gene Name:
ADRA2A
Uniprot ID:
Q28838
Molecular weight:
49252.0
General function:
Not Available
Specific function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol (By similarity).
Gene Name:
CHRM2
Uniprot ID:
P41985
Molecular weight:
51613.0
General function:
Involved in G-protein coupled receptor protein signalin
Specific function:
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
Gene Name:
ADRA2B
Uniprot ID:
O77700
Molecular weight:
42840.0
General function:
Involved in muscarinic acetylcholine receptor activity
Specific function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Gene Name:
CHRM3
Uniprot ID:
P41984
Molecular weight:
66103.0
General function:
Involved in lutropin-choriogonadotropic hormone recepto
Specific function:
Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.
Gene Name:
LHCGR
Uniprot ID:
Q28005
Molecular weight:
78456.0
General function:
Involved in protein-hormone receptor activity
Specific function:
Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.
Gene Name:
TSHR
Uniprot ID:
Q27987
Molecular weight:
86431.0
General function:
Involved in adrenocorticotropin receptor activity
Specific function:
Receptor for corticotropin (ACTH). This receptor is mediated by G proteins which activate adenylate cyclase (cAMP).
Gene Name:
MC2R
Uniprot ID:
P34974
Molecular weight:
33293.0
General function:
Involved in follicle-stimulating hormone receptor activity
Specific function:
G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
Gene Name:
FSHR
Uniprot ID:
P35376
Molecular weight:
78085.0
General function:
Not Available
Specific function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase. May couple to multiple functional responses in cell lines.
Gene Name:
CHRM4
Uniprot ID:
P41986
Molecular weight:
13221.0
General function:
Not Available
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
Q9TRE3
Molecular weight:
3427.0
General function:
Involved in melanocortin receptor activity
Specific function:
Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins (By similarity).
Gene Name:
MC5R
Uniprot ID:
P56451
Molecular weight:
36526.0

Only showing the first 50 proteins. There are 67 proteins in total.