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Record Information
Version1.0
Creation Date2016-09-30 22:26:27 UTC
Update Date2020-05-21 16:28:58 UTC
BMDB IDBMDB0000187
Secondary Accession Numbers
  • BMDB00187
Metabolite Identification
Common NameL-Serine
DescriptionL-Serine, also known as (S)-serine or L-ser, belongs to the class of organic compounds known as serine and derivatives. Serine and derivatives are compounds containing serine or a derivative thereof resulting from reaction of serine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. L-Serine is a drug which is used as a natural moisturizing agent in some cosmetics and skin care products. L-Serine exists as a solid, possibly soluble (in water), and a very strong basic compound (based on its pKa) molecule. L-Serine exists in all living species, ranging from bacteria to humans. L-Serine is a potentially toxic compound.
Structure
Thumb
Synonyms
ValueSource
(2S)-2-Amino-3-hydroxypropanoic acidChEBI
(S)-(-)-SerineChEBI
(S)-2-Amino-3-hydroxypropanoic acidChEBI
(S)-alpha-Amino-beta-hydroxypropionic acidChEBI
(S)-SerineChEBI
beta-Hydroxy-L-alanineChEBI
beta-HydroxyalanineChEBI
L-(-)-SerineChEBI
L-2-Amino-3-hydroxypropionic acidChEBI
L-3-Hydroxy-2-aminopropionic acidChEBI
L-3-Hydroxy-alanineChEBI
L-SerChEBI
L-SerinChEBI
SChEBI
SerChEBI
SERINEChEBI
(2S)-2-Amino-3-hydroxypropanoateGenerator
(S)-2-Amino-3-hydroxypropanoateGenerator
(S)-a-Amino-b-hydroxypropionateGenerator
(S)-a-Amino-b-hydroxypropionic acidGenerator
(S)-alpha-Amino-beta-hydroxypropionateGenerator
(S)-Α-amino-β-hydroxypropionateGenerator
(S)-Α-amino-β-hydroxypropionic acidGenerator
b-Hydroxy-L-alanineGenerator
Β-hydroxy-L-alanineGenerator
b-HydroxyalanineGenerator
Β-hydroxyalanineGenerator
L-2-Amino-3-hydroxypropionateGenerator
L-3-Hydroxy-2-aminopropionateGenerator
(-)-SerineHMDB
(S)-2-Amino-3-hydroxy-propanoateHMDB
(S)-2-Amino-3-hydroxy-propanoic acidHMDB
(S)-b-Amino-3-hydroxypropionateHMDB
(S)-b-Amino-3-hydroxypropionic acidHMDB
(S)-beta-Amino-3-hydroxypropionateHMDB
(S)-beta-Amino-3-hydroxypropionic acidHMDB
2-Amino-3-hydroxypropanoateHMDB
2-Amino-3-hydroxypropanoic acidHMDB
3-Hydroxy-L-alanineHMDB
L SerineHMDB
(3R,3'r,6S)-4,5-DIDEHYDRO-5,6-dihydro-BETA,BETA-carotene-3,3'-diolHMDB
Bo-xanHMDB
e 161bHMDB
XanthophyllHMDB
(3R,3'r,6S)-4,5-DIDEHYDRO-5,6-dihydro-b,b-carotene-3,3'-diolHMDB
(3R,3'r,6S)-4,5-DIDEHYDRO-5,6-dihydro-β,β-carotene-3,3'-diolHMDB
Chemical FormulaC3H7NO3
Average Molecular Weight105.0926
Monoisotopic Molecular Weight105.042593095
IUPAC Name(2S)-2-amino-3-hydroxypropanoic acid
Traditional NameL-serine
CAS Registry Number56-45-1
SMILES
N[C@@H](CO)C(O)=O
InChI Identifier
InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
InChI KeyMTCFGRXMJLQNBG-REOHCLBHSA-N
Chemical Taxonomy
Description belongs to the class of organic compounds known as serine and derivatives. Serine and derivatives are compounds containing serine or a derivative thereof resulting from reaction of serine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentSerine and derivatives
Alternative Parents
Substituents
  • Serine or derivatives
  • Alpha-amino acid
  • L-alpha-amino acid
  • Beta-hydroxy acid
  • Hydroxy acid
  • Amino acid
  • Carboxylic acid
  • Monocarboxylic acid or derivatives
  • Alcohol
  • Primary amine
  • Primary alcohol
  • Organooxygen compound
  • Organonitrogen compound
  • Hydrocarbon derivative
  • Primary aliphatic amine
  • Organic oxide
  • Organopnictogen compound
  • Carbonyl group
  • Organic oxygen compound
  • Amine
  • Organic nitrogen compound
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
StatusDetected and Quantified
Origin
  • Endogenous
BiofunctionNot Available
ApplicationNot Available
Cellular locations
  • Cytoplasm
  • Mitochondria
  • Peroxisome
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point228 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility425.0 mg/mLNot Available
LogP-3.07HANSCH,C ET AL. (1995)
Predicted Properties
PropertyValueSource
logP-3.4ALOGPS
logP-3.9ChemAxon
logS0.66ALOGPS
pKa (Strongest Acidic)2.03ChemAxon
pKa (Strongest Basic)8.93ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area83.55 ŲChemAxon
Rotatable Bond Count2ChemAxon
Refractivity22.04 m³·mol⁻¹ChemAxon
Polarizability9.39 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash Key
GC-MSGC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (3 TMS)splash10-0udi-0940000000-59d5e0f76fd204be8110View in MoNA
GC-MSGC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (3 TMS)splash10-0udi-0980000000-ab49fc3ee88db87d1a16View in MoNA
GC-MSGC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (2 TMS)splash10-0159-0900000000-8e169037bcbe1dcd5de8View in MoNA
GC-MSGC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (3 TMS)splash10-0uxr-0970000000-67271ed235e35c662db5View in MoNA
GC-MSGC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (3 TMS)splash10-00di-9540000000-1297bf302358bcf0f1c0View in MoNA
GC-MSGC-MS Spectrum - GC-MS (3 TMS)splash10-0uxr-1790000000-caaa37778f5a4686f5f0View in MoNA
GC-MSGC-MS Spectrum - EI-B (Non-derivatized)splash10-0159-0900000000-ae4f860052c41e9ba734View in MoNA
GC-MSGC-MS Spectrum - EI-B (Non-derivatized)splash10-0uxr-0590000000-ce32a8bfb64d16590b52View in MoNA
GC-MSGC-MS Spectrum - GC-EI-TOF (Non-derivatized)splash10-0udi-0940000000-59d5e0f76fd204be8110View in MoNA
GC-MSGC-MS Spectrum - GC-EI-TOF (Non-derivatized)splash10-0udi-0980000000-ab49fc3ee88db87d1a16View in MoNA
GC-MSGC-MS Spectrum - GC-EI-TOF (Non-derivatized)splash10-0159-0900000000-8e169037bcbe1dcd5de8View in MoNA
GC-MSGC-MS Spectrum - GC-EI-TOF (Non-derivatized)splash10-0uxr-0970000000-67271ed235e35c662db5View in MoNA
GC-MSGC-MS Spectrum - GC-EI-QQ (Non-derivatized)splash10-00dr-7966000000-7b5b37fd4ac885548172View in MoNA
GC-MSGC-MS Spectrum - GC-EI-TOF (Non-derivatized)splash10-00di-9540000000-1297bf302358bcf0f1c0View in MoNA
GC-MSGC-MS Spectrum - GC-MS (Non-derivatized)splash10-0uxr-1790000000-caaa37778f5a4686f5f0View in MoNA
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positivesplash10-06sl-9000000000-033631650075b940e0e2View in MoNA
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (2 TMS) - 70eV, Positivesplash10-0fkl-9420000000-ed7a327e1f071802a4ddView in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-03di-9100000000-38f84912ebfc7b4e8339View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-03dl-9000000000-89e57995d3ca765a20e8View in MoNA
LC-MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-01ox-9100000000-f3baf93032cc9f09cf2dView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-0zfr-0900000000-b6085e53e881cdaa1824View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-000i-9000000000-2e16e9d6f9b3c2688f8aView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-0a4i-9000000000-9857daa028fb3016a7e2View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-0006-0009200000-0617acd25c69bf24ad1fView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-0a4i-0900000000-823dfcf6229956372e31View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-0a4i-9000000000-eec63565f8a9fe4bd336View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-000i-9000000000-008412efd202c202d56aView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-0002-0930000000-932aedc4efb5e1dd5e7bView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-0w29-0951000000-cd0895e475dd50e4934dView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-00di-9000000000-15294ba22b153cf5ab5bView in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-014i-9000000000-48c370acff657443f0e6View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-0udi-0190000000-1bad10ba7388ce0c2249View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-0ue9-0792100000-9f2bfe40e4c01044d209View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-00di-9000000000-dfa7aca58cc28303ebc7View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-0udi-0900000000-282f31d8021649afdbe8View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negativesplash10-0udi-0290000000-eeee98e6b0514b08cd63View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negativesplash10-0udi-1900000000-ed66566e27a94ee99f13View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negativesplash10-00di-9100000000-b9f6b4b6ee7c88a9c569View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negativesplash10-00di-9000000000-929aea63ace0e20c6d43View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negativesplash10-00di-9000000000-ba9cd5b3e37ded5d3764View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positivesplash10-0a4i-6900000000-5622633ab0a27d2e5360View in MoNA
LC-MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positivesplash10-03di-9000000000-3e25ca80e2e62be19ac5View in MoNA
MSMass Spectrum (Electron Ionization)splash10-0200-9000000000-dc5e2afcfab602641180View in MoNA
1D NMR1H NMR SpectrumNot AvailableView in JSpectraViewer
2D NMR[1H,1H] 2D NMR SpectrumNot AvailableView in JSpectraViewer
2D NMR[1H,13C] 2D NMR SpectrumNot AvailableView in JSpectraViewer
Biological Properties
Cellular Locations
  • Cytoplasm
  • Mitochondria
  • Peroxisome
Biospecimen Locations
  • All Tissues
  • Blood
  • Colostrum
  • Liver
  • Longissimus Thoracis Muscle
  • Mammary Gland
  • Milk
  • Muscle
  • Placenta
  • Prostate Tissue
  • Ruminal Fluid
  • Semen
  • Semimembranosus Muscle
  • Testis
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
All TissuesExpected but not QuantifiedNot ApplicableNot SpecifiedNot SpecifiedNormal
  • Not Applicable
details
BloodDetected but not QuantifiedNot ApplicableNot SpecifiedNot Specified
Normal
details
BloodDetected and Quantified58.4 uMNot SpecifiedNot Specified
Normal
details
BloodDetected and Quantified71-84 uMNot SpecifiedNot Specified
Normal
details
BloodDetected and Quantified80.2 uMNot SpecifiedBothNormal details
BloodDetected and Quantified57-84 uMNot SpecifiedNot Specified
Normal
details
BloodDetected and Quantified86-89 uMNot SpecifiedNot Specified
Normal
details
BloodDetected but not QuantifiedNot ApplicableNot SpecifiedNot Specified
Normal
details
BloodDetected and Quantified85+/-14 uMNot SpecifiedNot Specified
Normal
    • The Bovine Metabo...
details
ColostrumDetected but not QuantifiedNot ApplicableNot SpecifiedNot Specified
Normal
details
LiverDetected but not QuantifiedNot ApplicableNot SpecifiedNot Specified
Normal
details
LiverDetected but not QuantifiedNot ApplicableNot SpecifiedNot Specified
Normal
details
LiverDetected but not QuantifiedNot ApplicableNot SpecifiedNot Specified
Normal
details
LiverDetected and Quantified422+/-114 nmol/g of tissueNot SpecifiedNot Specified
Normal
    • The Bovine Metabo...
details
Longissimus Thoracis MuscleDetected and Quantified165+/-36 nmol/g of tissueNot SpecifiedNot Specified
Normal
    • The Bovine Metabo...
details
Mammary GlandDetected but not QuantifiedNot ApplicableNot SpecifiedNot Specified
Normal
details
Mammary GlandDetected but not QuantifiedNot ApplicableNot SpecifiedNot Specified
Normal
details
MilkDetected but not QuantifiedNot ApplicableNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified15 +/- 1 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified18 +/- 1 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified15.7 +/- 0.2 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified15 +/- 1 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified19030.836 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified19030.836 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified19030.836 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified19030.836 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified18079.294 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified18079.294 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified18079.294 uMNot SpecifiedNot Specified
Normal
details
MuscleDetected but not QuantifiedNot ApplicableNot SpecifiedNot Specified
Normal
details
MuscleDetected and Quantified273-830 nmol/g of tissueNot SpecifiedNot Specified
Normal
details
PlacentaExpected but not QuantifiedNot ApplicableNot SpecifiedNot SpecifiedNormal
  • Not Applicable
details
Prostate TissueExpected but not QuantifiedNot ApplicableNot SpecifiedNot SpecifiedNormal
  • Not Applicable
details
Ruminal FluidDetected and Quantified50 +/- 14 uMNot SpecifiedNot Specified
Normal
    • Fozia Saleem, Sou...
details
Ruminal FluidDetected and Quantified85 +/- 29 uMNot SpecifiedNot Specified
Normal
    • Fozia Saleem, Sou...
details
Ruminal FluidDetected and Quantified123 +/- 57 uMNot SpecifiedNot Specified
Normal
    • Fozia Saleem, Sou...
details
Ruminal FluidDetected and Quantified49 +/- 25 uMNot SpecifiedNot Specified
Normal
    • Fozia Saleem, Sou...
details
Ruminal FluidDetected and Quantified49 +/- 25 uMNot SpecifiedNot Specified
Normal
    • Fozia Saleem, Sou...
details
Ruminal FluidDetected and Quantified45.29 +/- 23.71 uMNot SpecifiedNot SpecifiedNormal
    • Fozia Saleem, Sou...
details
Ruminal FluidDetected and Quantified547+/-187 uMNot SpecifiedNot Specified
Normal
    • The Bovine Metabo...
details
SemenDetected but not QuantifiedNot ApplicableNot SpecifiedNot Specified
Normal
details
SemenDetected but not QuantifiedNot ApplicableNot SpecifiedNot Specified
Normal
details
SemenDetected but not QuantifiedNot ApplicableNot SpecifiedNot Specified
Normal
details
Semimembranosus MuscleDetected and Quantified161+/-31 nmol/g of tissueNot SpecifiedNot Specified
Normal
    • The Bovine Metabo...
details
TestisDetected and Quantified630-830 nmol/g of tissueNot SpecifiedNot Specified
Normal
details
TestisDetected and Quantified230 nmol/g of tissueNot SpecifiedNot Specified
Normal
details
TestisDetected and Quantified272+/-58 nmol/g of tissueNot SpecifiedNot Specified
Normal
    • The Bovine Metabo...
details
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected but not QuantifiedNot ApplicableNot SpecifiedNot Specified
All Mycobacterium avium subsp. paratuberculosis-infected
details
BloodDetected but not QuantifiedNot ApplicableNot SpecifiedNot Specified
High dose Mycobacterium avium subsp. paratuberculosis-infected
details
BloodDetected but not QuantifiedNot ApplicableNot SpecifiedNot Specified
Low dose Mycobacterium avium subsp. paratuberculosis-infected
details
BloodDetected and Quantified61.5 uMNot SpecifiedNot Specified
Bovine spongiform encephalopathy positive
details
BloodDetected but not QuantifiedNot ApplicableNot SpecifiedNot Specified
Sub/clinical ketosis
details
BloodDetected and Quantified66.7 uMNot SpecifiedNot Specified
Bovine spongiform encephalopathy negative
details
ColostrumDetected but not QuantifiedNot ApplicableNot SpecifiedNot Specified
Commercial Product/bacterial growth on ground beef
details
MuscleDetected but not QuantifiedNot ApplicableNot SpecifiedNot Specified
Commercial Product/bacterial growth on ground beef
details
Ruminal FluidDetected and Quantified116.49 +/- 57.91 uMNot SpecifiedNot SpecifiedRumen acidosis
    • Fozia Saleem, Sou...
details
HMDB IDHMDB0000187
DrugBank IDDB00133
Phenol Explorer Compound IDNot Available
FooDB IDFDB012739
KNApSAcK IDC00001393
Chemspider ID5736
KEGG Compound IDC00065
BioCyc IDSER
BiGG ID33717
Wikipedia LinkL-serine
METLIN ID5203
PubChem Compound5951
PDB IDNot Available
ChEBI ID17115
References
Synthesis ReferenceQin, Wei-min; Cao, Fei; Zhou, Hua; Li, Zhen-jiang; Wei, Ping. Asymmetric synthesis of D- and L-serine with "Glycine equivalent" method. Huaxue Shiji (2005), 27(11), 643-644, 670.
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Scano P, Murgia A, Pirisi FM, Caboni P: A gas chromatography-mass spectrometry-based metabolomic approach for the characterization of goat milk compared with cow milk. J Dairy Sci. 2014 Oct;97(10):6057-66. doi: 10.3168/jds.2014-8247. Epub 2014 Aug 6. [PubMed:25108860 ]
  2. Mung D, Li L: Development of Chemical Isotope Labeling LC-MS for Milk Metabolomics: Comprehensive and Quantitative Profiling of the Amine/Phenol Submetabolome. Anal Chem. 2017 Apr 18;89(8):4435-4443. doi: 10.1021/acs.analchem.6b03737. Epub 2017 Mar 28. [PubMed:28306241 ]
  3. Mung D, Li L: Applying quantitative metabolomics based on chemical isotope labeling LC-MS for detecting potential milk adulterant in human milk. Anal Chim Acta. 2018 Feb 25;1001:78-85. doi: 10.1016/j.aca.2017.11.019. Epub 2017 Nov 14. [PubMed:29291809 ]
  4. A. Foroutan et al. (2019). A. Foroutan et al. The Chemical Composition of Commercial Cow's Milk (in preparation). Journal of Agricultural and Food Chemistry.
  5. Fooddata+, The Technical University of Denmark (DTU) [Link]

Enzymes

General function:
Amino acid transport and metabolism
Specific function:
Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine (By similarity).
Gene Name:
SRR
Uniprot ID:
A0JNI4
Molecular weight:
36181.0
Reactions
L-Serine → D-Serinedetails
General function:
Amino acid transport and metabolism
Specific function:
Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis. Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Also required for mitochondrial translation by producing 5,10-methylenetetrahydrofolate; 5,10-methylenetetrahydrofolate providing methyl donors to produce the taurinomethyluridine base at the wobble position of some mitochondrial tRNAs. Associates with mitochondrial DNA. In addition to its role in mitochondria, also plays a role in the deubiquitination of target proteins as component of the BRISC complex: required for IFNAR1 deubiquitination by the BRISC complex.
Gene Name:
SHMT2
Uniprot ID:
Q3SZ20
Molecular weight:
55605.0
Reactions
5,10-Methylene-THF + Glycine + Water → Tetrahydrofolic acid + L-Serinedetails
General function:
Translation, ribosomal structure and biogenesis
Specific function:
Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
Gene Name:
SARS2
Uniprot ID:
Q9N0F3
Molecular weight:
58296.0
Reactions
L-Serine + Adenosine triphosphate + L-Seryl-tRNA → Adenosine monophosphate + L-Seryl-tRNA(Ser) + Pyrophosphatedetails
General function:
Coenzyme transport and metabolism
Specific function:
Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference (By similarity). Required for adipocyte cell viability and metabolic homeostasis (By similarity).
Gene Name:
SPTLC1
Uniprot ID:
Q3MHG1
Molecular weight:
52788.0
Reactions
Palmityl-CoA + L-Serine → 3-Dehydrosphinganine + Carbon dioxidedetails
General function:
Translation, ribosomal structure and biogenesis
Specific function:
Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA.
Gene Name:
SARS1
Uniprot ID:
Q9GMB8
Molecular weight:
58605.0
Reactions
L-Serine + Adenosine triphosphate + L-Seryl-tRNA → Adenosine monophosphate + L-Seryl-tRNA(Ser) + Pyrophosphatedetails
General function:
Amino acid transport and metabolism
Specific function:
Interconversion of serine and glycine.
Gene Name:
SHMT1
Uniprot ID:
Q5E9P9
Molecular weight:
52978.0
Reactions
L-Serine + Tetrahydrofolic acid → Glycine + 5,10-Methylene-THF + Waterdetails
Tetrahydrofolic acid + L-Serine → 5,10-Methylene-THF + Glycine + Waterdetails
General function:
Amino acid transport and metabolism
Specific function:
Not Available
Gene Name:
SDS
Uniprot ID:
Q0VCW4
Molecular weight:
34441.0
Reactions
L-Serine → Pyruvic acid + Ammoniadetails
General function:
Coenzyme transport and metabolism
Specific function:
Not Available
Gene Name:
GCAT
Uniprot ID:
Q0P5L8
Molecular weight:
45166.0
Reactions
Palmityl-CoA + L-Serine → 3-Dehydrosphinganine + Carbon dioxidedetails
General function:
Amino acid transport and metabolism
Specific function:
Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates (By similarity).
Gene Name:
PSPH
Uniprot ID:
Q2KHU0
Molecular weight:
24850.0
Reactions
Phosphoserine + Water → L-Serine + Hydrogen phosphatedetails
General function:
Amino acid transport and metabolism
Specific function:
Not Available
Gene Name:
AGXT
Uniprot ID:
A7MBF1
Molecular weight:
45292.0
Reactions
Pyruvic acid + L-Serine → Hydroxypyruvic acid + L-Alaninedetails
General function:
Not Available
Specific function:
Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. In membranes, PTDSS1 catalyzes mainly the conversion of phosphatidylcholine. Also converts, in vitro and to a lesser extent, phosphatidylethanolamine (By similarity).
Gene Name:
PTDSS1
Uniprot ID:
Q2KHY9
Molecular weight:
55416.0
Reactions
Phosphatidylcholine + L-Serine → an L-1-Phosphatidylserine + Cholinedetails
PC(14:0/14:0) + L-Serine → Choline + PS(14:0/14:0)details
PC(14:0/14:1(9Z)) + L-Serine → Choline + PS(14:0/14:1(9Z))details
PC(14:0/16:0) + L-Serine → Choline + PS(14:0/16:0)details
PC(14:0/16:1(9Z)) + L-Serine → Choline + PS(14:0/16:1(9Z))details
PC(14:0/18:0) + L-Serine → Choline + PS(14:0/18:0)details
PC(14:0/18:1(9Z)) + L-Serine → Choline + PS(14:0/18:1(9Z))details
PC(14:0/18:2(9Z,12Z)) + L-Serine → Choline + PS(14:0/18:2(9Z,12Z))details
PC(14:0/18:3(9Z,12Z,15Z)) + L-Serine → Choline + PS(14:0/18:3(9Z,12Z,15Z))details
PC(14:0/20:3(8Z,11Z,14Z)) + L-Serine → Choline + PS(14:0/20:3(8Z,11Z,14Z))details
PC(14:0/20:4(5Z,8Z,11Z,14Z)) + L-Serine → Choline + PS(14:0/20:4(5Z,8Z,11Z,14Z))details
PC(14:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) + L-Serine → Choline + PS(14:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))details
PC(14:1(9Z)/14:1(9Z)) + L-Serine → Choline + PS(14:1(9Z)/14:1(9Z))details
PC(14:1(9Z)/16:0) + L-Serine → Choline + PS(14:1(9Z)/16:0)details
PC(14:1(9Z)/16:1(9Z)) + L-Serine → Choline + PS(14:1(9Z)/16:1(9Z))details
PC(14:1(9Z)/18:0) + L-Serine → Choline + PS(14:1(9Z)/18:0)details
PC(14:1(9Z)/18:1(9Z)) + L-Serine → Choline + PS(14:1(9Z)/18:1(9Z))details
PC(14:1(9Z)/18:2(9Z,12Z)) + L-Serine → Choline + PS(14:1(9Z)/18:2(9Z,12Z))details
PC(14:1(9Z)/18:3(9Z,12Z,15Z)) + L-Serine → Choline + PS(14:1(9Z)/18:3(9Z,12Z,15Z))details
PC(14:1(9Z)/20:3(8Z,11Z,14Z)) + L-Serine → Choline + PS(14:1(9Z)/20:3(8Z,11Z,14Z))details
PC(14:1(9Z)/20:4(5Z,8Z,11Z,14Z)) + L-Serine → Choline + PS(14:1(9Z)/20:4(5Z,8Z,11Z,14Z))details
PC(14:1(9Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) + L-Serine → Choline + PS(14:1(9Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))details
PC(16:0/16:1(9Z)) + L-Serine → Choline + PS(16:0/16:1(9Z))details
PC(16:0/18:0) + L-Serine → Choline + PS(16:0/18:0)details
PC(16:0/18:1(11Z)) + L-Serine → Choline + PS(16:0/18:1(11Z))details
PC(16:0/18:1(9Z)) + L-Serine → Choline + PS(16:0/18:1(9Z))details
PC(16:0/18:2(9Z,12Z)) + L-Serine → Choline + PS(16:0/18:2(9Z,12Z))details
PC(16:0/18:3(6Z,9Z,12Z)) + L-Serine → Choline + PS(16:0/18:3(6Z,9Z,12Z))details
PC(16:0/18:3(9Z,12Z,15Z)) + L-Serine → Choline + PS(16:0/18:3(9Z,12Z,15Z))details
PC(16:0/20:0) + L-Serine → Choline + PS(16:0/20:0)details
PC(16:0/20:1(11Z)) + L-Serine → Choline + PS(16:0/20:1(11Z))details
PC(16:0/20:3(8Z,11Z,14Z)) + L-Serine → Choline + PS(16:0/20:3(8Z,11Z,14Z))details
PC(16:0/20:4(5Z,8Z,11Z,14Z)) + L-Serine → Choline + PS(16:0/20:4(5Z,8Z,11Z,14Z))details
PC(16:0/22:0) + L-Serine → Choline + PS(16:0/22:0)details
PC(16:0/22:1(13Z)) + L-Serine → Choline + PS(16:0/22:1(13Z))details
PC(16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) + L-Serine → Choline + PS(16:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))details
PC(16:1(9Z)/16:1(9Z)) + L-Serine → Choline + PS(16:1(9Z)/16:1(9Z))details
PC(16:1(9Z)/18:0) + L-Serine → Choline + PS(16:1(9Z)/18:0)details
PC(16:1(9Z)/18:1(9Z)) + L-Serine → Choline + PS(16:1(9Z)/18:1(9Z))details
PC(16:1(9Z)/18:2(9Z,12Z)) + L-Serine → Choline + PS(16:1(9Z)/18:2(9Z,12Z))details
PC(16:1(9Z)/18:3(9Z,12Z,15Z)) + L-Serine → Choline + PS(16:1(9Z)/18:3(9Z,12Z,15Z))details
PC(16:1(9Z)/20:3(8Z,11Z,14Z)) + L-Serine → Choline + PS(16:1(9Z)/20:3(8Z,11Z,14Z))details
PC(16:1(9Z)/20:4(5Z,8Z,11Z,14Z)) + L-Serine → Choline + PS(16:1(9Z)/20:4(5Z,8Z,11Z,14Z))details
PC(16:1(9Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) + L-Serine → Choline + PS(16:1(9Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))details
PC(18:0/18:0) + L-Serine → Choline + PS(18:0/18:0)details
PC(18:0/18:1(11Z)) + L-Serine → Choline + PS(18:0/18:1(11Z))details
PC(18:0/18:1(9Z)) + L-Serine → Choline + PS(18:0/18:1(9Z))details
PC(18:0/18:2(9Z,12Z)) + L-Serine → Choline + PS(18:0/18:2(9Z,12Z))details
PC(18:0/18:3(6Z,9Z,12Z)) + L-Serine → Choline + PS(18:0/18:3(6Z,9Z,12Z))details
PC(18:0/18:3(9Z,12Z,15Z)) + L-Serine → Choline + PS(18:0/18:3(9Z,12Z,15Z))details
PC(18:0/20:0) + L-Serine → Choline + PS(18:0/20:0)details
PC(18:0/20:1(11Z)) + L-Serine → Choline + PS(18:0/20:1(11Z))details
PC(18:0/20:3(8Z,11Z,14Z)) + L-Serine → Choline + PS(18:0/20:3(8Z,11Z,14Z))details
PC(18:0/20:4(5Z,8Z,11Z,14Z)) + L-Serine → Choline + PS(18:0/20:4(5Z,8Z,11Z,14Z))details
PC(18:0/20:4(8Z,11Z,14Z,17Z)) + L-Serine → Choline + PS(18:0/20:4(8Z,11Z,14Z,17Z))details
PC(18:0/22:0) + L-Serine → Choline + PS(18:0/22:0)details
PC(18:0/22:1(13Z)) + L-Serine → Choline + PS(18:0/22:1(13Z))details
PC(18:0/22:5(7Z,10Z,13Z,16Z,19Z)) + L-Serine → Choline + PS(18:0/22:5(7Z,10Z,13Z,16Z,19Z))details
PC(18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) + L-Serine → Choline + PS(18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))details
PC(18:1(11Z)/18:1(11Z)) + L-Serine → Choline + PS(18:1(11Z)/18:1(11Z))details
PC(18:1(11Z)/18:2(9Z,12Z)) + L-Serine → Choline + PS(18:1(11Z)/18:2(9Z,12Z))details
PC(18:1(11Z)/18:3(6Z,9Z,12Z)) + L-Serine → Choline + PS(18:1(11Z)/18:3(6Z,9Z,12Z))details
PC(18:1(11Z)/18:3(9Z,12Z,15Z)) + L-Serine → Choline + PS(18:1(11Z)/18:3(9Z,12Z,15Z))details
PC(18:1(11Z)/20:0) + L-Serine → Choline + PS(18:1(11Z)/20:0)details
PC(18:1(11Z)/20:1(11Z)) + L-Serine → Choline + PS(18:1(11Z)/20:1(11Z))details
PC(18:1(11Z)/22:0) + L-Serine → Choline + PS(18:1(11Z)/22:0)details
PC(18:1(11Z)/22:1(13Z)) + L-Serine → Choline + PS(18:1(11Z)/22:1(13Z))details
PC(18:1(9Z)/18:1(9Z)) + L-Serine → Choline + PS(18:1(9Z)/18:1(9Z))details
PC(18:1(9Z)/18:2(9Z,12Z)) + L-Serine → Choline + PS(18:1(9Z)/18:2(9Z,12Z))details
PC(18:1(9Z)/18:3(6Z,9Z,12Z)) + L-Serine → Choline + PS(18:1(9Z)/18:3(6Z,9Z,12Z))details
PC(18:1(9Z)/18:3(9Z,12Z,15Z)) + L-Serine → Choline + PS(18:1(9Z)/18:3(9Z,12Z,15Z))details
PC(18:1(9Z)/20:0) + L-Serine → Choline + PS(18:1(9Z)/20:0)details
PC(18:1(9Z)/20:1(11Z)) + L-Serine → Choline + PS(18:1(9Z)/20:1(11Z))details
PC(18:1(9Z)/20:3(8Z,11Z,14Z)) + L-Serine → Choline + PS(18:1(9Z)/20:3(8Z,11Z,14Z))details
PC(18:1(9Z)/20:4(5Z,8Z,11Z,14Z)) + L-Serine → Choline + PS(18:1(9Z)/20:4(5Z,8Z,11Z,14Z))details
PC(18:1(9Z)/22:0) + L-Serine → Choline + PS(18:1(9Z)/22:0)details
PC(18:1(9Z)/22:1(13Z)) + L-Serine → Choline + PS(18:1(9Z)/22:1(13Z))details
PC(18:1(9Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) + L-Serine → Choline + PS(18:1(9Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))details
PC(18:2(9Z,12Z)/18:2(9Z,12Z)) + L-Serine → Choline + PS(18:2(9Z,12Z)/18:2(9Z,12Z))details
PC(18:2(9Z,12Z)/18:3(6Z,9Z,12Z)) + L-Serine → Choline + PS(18:2(9Z,12Z)/18:3(6Z,9Z,12Z))details
PC(18:2(9Z,12Z)/18:3(9Z,12Z,15Z)) + L-Serine → Choline + PS(18:2(9Z,12Z)/18:3(9Z,12Z,15Z))details
PC(18:2(9Z,12Z)/20:0) + L-Serine → Choline + PS(18:2(9Z,12Z)/20:0)details
PC(18:2(9Z,12Z)/20:1(11Z)) + L-Serine → Choline + PS(18:2(9Z,12Z)/20:1(11Z))details
PC(18:2(9Z,12Z)/20:3(8Z,11Z,14Z)) + L-Serine → Choline + PS(18:2(9Z,12Z)/20:3(8Z,11Z,14Z))details
PC(18:2(9Z,12Z)/20:4(5Z,8Z,11Z,14Z)) + L-Serine → Choline + PS(18:2(9Z,12Z)/20:4(5Z,8Z,11Z,14Z))details
PC(18:2(9Z,12Z)/22:0) + L-Serine → Choline + PS(18:2(9Z,12Z)/22:0)details
PC(18:2(9Z,12Z)/22:1(13Z)) + L-Serine → Choline + PS(18:2(9Z,12Z)/22:1(13Z))details
PC(18:2(9Z,12Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) + L-Serine → Choline + PS(18:2(9Z,12Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))details
PC(18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z)) + L-Serine → Choline + PS(18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z))details
PC(18:3(6Z,9Z,12Z)/18:3(9Z,12Z,15Z)) + L-Serine → Choline + PS(18:3(6Z,9Z,12Z)/18:3(9Z,12Z,15Z))details
PC(18:3(6Z,9Z,12Z)/20:0) + L-Serine → Choline + PS(18:3(6Z,9Z,12Z)/20:0)details
PC(18:3(6Z,9Z,12Z)/20:1(11Z)) + L-Serine → Choline + PS(18:3(6Z,9Z,12Z)/20:1(11Z))details
PC(18:3(6Z,9Z,12Z)/22:0) + L-Serine → Choline + PS(18:3(6Z,9Z,12Z)/22:0)details
PC(18:3(6Z,9Z,12Z)/22:1(13Z)) + L-Serine → Choline + PS(18:3(6Z,9Z,12Z)/22:1(13Z))details
PC(18:3(9Z,12Z,15Z)/18:3(9Z,12Z,15Z)) + L-Serine → Choline + PS(18:3(9Z,12Z,15Z)/18:3(9Z,12Z,15Z))details
PC(18:3(9Z,12Z,15Z)/20:0) + L-Serine → Choline + PS(18:3(9Z,12Z,15Z)/20:0)details
PC(18:3(9Z,12Z,15Z)/20:1(11Z)) + L-Serine → Choline + PS(18:3(9Z,12Z,15Z)/20:1(11Z))details
PC(18:3(9Z,12Z,15Z)/20:3(8Z,11Z,14Z)) + L-Serine → Choline + PS(18:3(9Z,12Z,15Z)/20:3(8Z,11Z,14Z))details
PC(18:3(9Z,12Z,15Z)/20:4(5Z,8Z,11Z,14Z)) + L-Serine → Choline + PS(18:3(9Z,12Z,15Z)/20:4(5Z,8Z,11Z,14Z))details
PC(18:3(9Z,12Z,15Z)/22:0) + L-Serine → Choline + PS(18:3(9Z,12Z,15Z)/22:0)details
PC(18:3(9Z,12Z,15Z)/22:1(13Z)) + L-Serine → Choline + PS(18:3(9Z,12Z,15Z)/22:1(13Z))details
PC(18:3(9Z,12Z,15Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) + L-Serine → Choline + PS(18:3(9Z,12Z,15Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))details
PC(20:0/20:0) + L-Serine → Choline + PS(20:0/20:0)details
PC(20:0/20:1(11Z)) + L-Serine → Choline + PS(20:0/20:1(11Z))details
PC(20:0/22:0) + L-Serine → Choline + PS(20:0/22:0)details
PC(20:0/22:1(13Z)) + L-Serine → Choline + PS(20:0/22:1(13Z))details
PC(20:1(11Z)/20:1(11Z)) + L-Serine → Choline + PS(20:1(11Z)/20:1(11Z))details
PC(20:1(11Z)/22:0) + L-Serine → Choline + PS(20:1(11Z)/22:0)details
PC(20:1(11Z)/22:1(13Z)) + L-Serine → Choline + PS(20:1(11Z)/22:1(13Z))details
PC(20:3(8Z,11Z,14Z)/20:3(8Z,11Z,14Z)) + L-Serine → Choline + PS(20:3(8Z,11Z,14Z)/20:3(8Z,11Z,14Z))details
PC(20:3(8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z)) + L-Serine → Choline + PS(20:3(8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))details
PC(20:3(8Z,11Z,14Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) + L-Serine → Choline + PS(20:3(8Z,11Z,14Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))details
PC(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z)) + L-Serine → Choline + PS(20:4(5Z,8Z,11Z,14Z)/20:4(5Z,8Z,11Z,14Z))details
PC(20:4(5Z,8Z,11Z,14Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) + L-Serine → Choline + PS(20:4(5Z,8Z,11Z,14Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))details
PC(22:0/22:0) + L-Serine → Choline + PS(22:0/22:0)details
PC(22:0/22:1(13Z)) + L-Serine → Choline + PS(22:0/22:1(13Z))details
PC(22:1(13Z)/22:1(13Z)) + L-Serine → Choline + PS(22:1(13Z)/22:1(13Z))details
PC(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z)) + L-Serine → Choline + PS(22:6(4Z,7Z,10Z,13Z,16Z,19Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))details
General function:
Not Available
Specific function:
Not Available
Gene Name:
CBS
Uniprot ID:
F1MEW4
Molecular weight:
62867.0
Reactions
L-Serine + Selenohomocysteine → Selenocystathionine + Waterdetails
Homocysteine + L-Serine → Water + L-Cystathioninedetails
L-Homoserine + L-Serine → L-Cystathionine + Waterdetails