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Record Information
Version1.0
Creation Date2016-09-30 22:33:12 UTC
Update Date2020-05-11 22:28:08 UTC
BMDB IDBMDB0000586
Secondary Accession Numbers
  • BMDB00586
Metabolite Identification
Common NamePotassium
DescriptionPotassium, also known as K+ or potassium ion, belongs to the class of inorganic compounds known as homogeneous alkali metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a alkali metal atom. Potassium exists as a solid, possibly soluble (in water), and possibly neutral molecule. Potassium exists in all living species, ranging from bacteria to humans. Potassium is a potentially toxic compound.
Structure
Thumb
Synonyms
ValueSource
K(+)ChEBI
K+ChEBI
POTASSIUM ionChEBI
Potassium(1+)Kegg
Nabumeton aKegg
KaliumHMDB
Potassium (ion)HMDB
Potassium (k+)HMDB
Potassium cationHMDB
Potassium ion (k+)HMDB
Potassium ion (K1+)HMDB
Potassium ion(+)HMDB
Potassium ion(1+)HMDB
Potassium monocationHMDB
Potassium(+)HMDB
Potassium(1+) ionHMDB
Potassium(I) cationHMDB
Liver regeneration factor 1HMDB
LRF-1HMDB
LRF1 Transcription factorHMDB
Chemical FormulaK
Average Molecular Weight39.0983
Monoisotopic Molecular Weight38.963706861
IUPAC Namepotassium(1+) ion
Traditional Namepotassium(1+) ion
CAS Registry Number7440-09-7
SMILES
[K+]
InChI Identifier
InChI=1S/K/q+1
InChI KeyNPYPAHLBTDXSSS-UHFFFAOYSA-N
Chemical Taxonomy
Description belongs to the class of inorganic compounds known as homogeneous alkali metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a alkali metal atom.
KingdomInorganic compounds
Super ClassHomogeneous metal compounds
ClassHomogeneous alkali metal compounds
Sub ClassNot Available
Direct ParentHomogeneous alkali metal compounds
Alternative ParentsNot Available
Substituents
  • Homogeneous alkali metal
Molecular FrameworkNot Available
External Descriptors
Ontology
StatusDetected and Quantified
Origin
  • Exogenous
BiofunctionNot Available
ApplicationNot Available
Cellular locations
  • Golgi
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point63.2 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP0.2ChemAxon
pKa (Strongest Acidic)3.09ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m³·mol⁻¹ChemAxon
Polarizability1.78 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-000i-9000000000-560fc6f738e9570ec8a2View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-000i-9000000000-560fc6f738e9570ec8a2View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-000i-9000000000-560fc6f738e9570ec8a2View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-000i-9000000000-bcbe5ea7d5d32f6a9598View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-000i-9000000000-bcbe5ea7d5d32f6a9598View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-000i-9000000000-bcbe5ea7d5d32f6a9598View in MoNA
Biological Properties
Cellular Locations
  • Golgi
Biospecimen Locations
  • Blood
  • Liver
  • Longissimus Thoracis Muscle
  • Milk
  • Ruminal Fluid
  • Semimembranosus Muscle
  • Testis
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified4710 uMNot SpecifiedNot Specified
Normal
details
BloodDetected and Quantified3900 +/- 20 uMNot SpecifiedBothNormal details
BloodDetected and Quantified3810 +/- 80 uMNot SpecifiedNot Specified
Normal
    • Abdullah BASOGLU,...
details
BloodDetected and Quantified4296+/-388 uMNot SpecifiedNot Specified
Normal
    • The Bovine Metabo...
details
LiverDetected and Quantified46154+/-8295 nmol/g of tissueNot SpecifiedNot Specified
Normal
    • The Bovine Metabo...
details
Longissimus Thoracis MuscleDetected and Quantified49300+/-7605 nmol/g of tissueNot SpecifiedNot Specified
Normal
    • The Bovine Metabo...
details
MilkDetected and Quantified34912.272 uMNot SpecifiedNot Specified
Normal
    • NRC. 1989. Recomm...
details
MilkDetected and Quantified31000 - 43000 uMNot SpecifiedNot SpecifiedNormal details
MilkDetected and Quantified38876.371 uMNot SpecifiedNot SpecifiedNormal
    • Park, Y. W; Juáre...
details
MilkDetected and Quantified35039.887 uMNot SpecifiedNot SpecifiedNormal details
MilkDetected and Quantified37853.308 uMNot SpecifiedNot SpecifiedNormal details
MilkDetected and Quantified38876.371 uMNot SpecifiedNot SpecifiedNormal details
MilkDetected and Quantified39387.902 uMNot SpecifiedNot SpecifiedNormal details
MilkDetected and Quantified40155.199 uMNot SpecifiedNot SpecifiedNormal details
MilkDetected and Quantified40666.73 uMNot SpecifiedNot SpecifiedNormal details
MilkDetected and Quantified41178.261 uMNot SpecifiedNot SpecifiedNormal details
MilkDetected and Quantified27763 +/- 5593 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified32800 +/- 2591 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified35991 +/- 3736 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified33641 +/- 811 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified35400 - 40600 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified35500 - 42400 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified38620.605 - 42457.0889 uMNot SpecifiedNot SpecifiedNormal details
MilkDetected and Quantified35551.418 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified35551.418 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified38364.839 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified42457.0889 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified64708.696 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified46037.807 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified41434.0265 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified38364.839 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified46549.338 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified43735.917 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified39899.433 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified39899.433 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified39132.136 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified39132.136 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified38620.605 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified46549.338 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified41434.0265 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified46549.338 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified35807.183 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified35807.183 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified40410.964 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified40155.199 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified40410.964 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified33761.0587 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified33761.0587 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified37853.308 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified36830.246 uMNot SpecifiedNot Specified
Normal
details
MilkDetected and Quantified36830.246 uMNot SpecifiedNot Specified
Normal
details
Ruminal FluidDetected and Quantified39878+/-6579 uMNot SpecifiedNot Specified
Normal
    • The Bovine Metabo...
details
Ruminal FluidDetected and Quantified18120 +/- 153 uMNot SpecifiedNot Specified
Normal
    • Fozia Saleem, Sou...
details
Semimembranosus MuscleDetected and Quantified51519+/-7094 nmol/g of tissueNot SpecifiedNot Specified
Normal
    • The Bovine Metabo...
details
TestisDetected and Quantified48919+/-8298 nmol/g of tissueNot SpecifiedNot Specified
Normal
    • The Bovine Metabo...
details
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified4650 uMNot SpecifiedNot Specified
Treated with bovine somatotropin
details
BloodDetected and Quantified3050 +/- 100 uMNot SpecifiedNot Specified
Left displaced abomasum (LDA)
    • Abdullah BASOGLU,...
details
BloodDetected and Quantified2890 +/- 190 uMNot SpecifiedNot Specified
Right displaced abomasum (RDA)
    • Abdullah BASOGLU,...
details
HMDB IDHMDB0000586
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB003521
KNApSAcK IDNot Available
Chemspider IDNot Available
KEGG Compound IDC00238
BioCyc IDNot Available
BiGG ID34349
Wikipedia LinkPotassium
METLIN ID3197
PubChem Compound813
PDB IDNot Available
ChEBI ID29103
References
Synthesis ReferenceAlberti, Augusto. Recovering potassium salts from the refuse liquor of the manufacture of tartaric acid. (1910), US 957295 19100510 CAN 4:13164 AN 1910:13164
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Gaucheron F: The minerals of milk. Reprod Nutr Dev. 2005 Jul-Aug;45(4):473-83. doi: 10.1051/rnd:2005030. [PubMed:16045895 ]
  2. Tsioulpas A, Grandison AS, Lewis MJ: Changes in physical properties of bovine milk from the colostrum period to early lactation. J Dairy Sci. 2007 Nov;90(11):5012-7. doi: 10.3168/jds.2007-0192. [PubMed:17954740 ]
  3. Auldist MJ, Walsh BJ, Thomson NA: Seasonal and lactational influences on bovine milk composition in New Zealand. J Dairy Res. 1998 Aug;65(3):401-11. [PubMed:9718493 ]
  4. Gaucheron F: Milk and dairy products: a unique micronutrient combination. J Am Coll Nutr. 2011 Oct;30(5 Suppl 1):400S-9S. [PubMed:22081685 ]
  5. NA (1989). NRC. 1989. Recommended Dietary Allowances. 10th ed. Natl. Acad. Press, Washington, DC.. The National Academies Press.
  6. Park, Y. W; Juárez, Manuela ; Ramos, M.; Haenlein, G. F. W. (2007). Park, Y. W; Juárez, Manuela ; Ramos, M.; Haenlein, G. F. W.. Physico-chemical characteristics of goat and sheep milk. Small Ruminant Res.(2007) 68:88-113 doi: 10.1016/j.smallrumres.2006.09.013. Small Ruminant Research.
  7. A. Foroutan et al. (2019). A. Foroutan et al. The Chemical Composition of Commercial Cow's Milk (in preparation). Journal of Agricultural and Food Chemistry.
  8. USDA Food Composition Databases [Link]
  9. Fooddata+, The Technical University of Denmark (DTU) [Link]

Only showing the first 50 proteins. There are 102 proteins in total.

Enzymes

General function:
Inorganic ion transport and metabolism
Specific function:
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
Gene Name:
ATP1A1
Uniprot ID:
Q08DA1
Molecular weight:
112643.0
General function:
Inorganic ion transport and metabolism
Specific function:
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients (By similarity).
Gene Name:
ATP1A2
Uniprot ID:
A2VDL6
Molecular weight:
112179.0
General function:
Coenzyme transport and metabolism
Specific function:
Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
Gene Name:
MAT2A
Uniprot ID:
A7E3T7
Molecular weight:
43691.0
General function:
Lipid transport and metabolism
Specific function:
This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism.
Gene Name:
ACAT1
Uniprot ID:
Q29RZ0
Molecular weight:
44889.0
General function:
Coenzyme transport and metabolism
Specific function:
Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
Gene Name:
MAT1A
Uniprot ID:
Q2KJC6
Molecular weight:
43761.0
General function:
Nucleotide transport and metabolism
Specific function:
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (Probable). Plays a role in modulating cellular differentiation (By similarity).
Gene Name:
GMPR2
Uniprot ID:
Q32L93
Molecular weight:
38033.0
General function:
Carbohydrate transport and metabolism
Specific function:
Not Available
Gene Name:
PKM
Uniprot ID:
B3IVN4
Molecular weight:
16527.0
General function:
Carbohydrate transport and metabolism
Specific function:
Not Available
Gene Name:
PKM2
Uniprot ID:
Q3ZC87
Molecular weight:
61428.0
General function:
Carbohydrate transport and metabolism
Specific function:
Not Available
Gene Name:
PKLR
Uniprot ID:
Q1JPG7
Molecular weight:
56870.0
General function:
Carbohydrate transport and metabolism
Specific function:
Not Available
Gene Name:
PKM
Uniprot ID:
A5D984
Molecular weight:
57949.0
General function:
Involved in ATP binding
Specific function:
Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.
Gene Name:
TTL
Uniprot ID:
P38584
Molecular weight:
43270.0
General function:
Energy production and conversion
Specific function:
The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).
Gene Name:
BCKDHA
Uniprot ID:
P11178
Molecular weight:
51678.0
General function:
Nucleotide transport and metabolism
Specific function:
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
Gene Name:
GMPR
Uniprot ID:
Q08DA2
Molecular weight:
37504.0
General function:
Nucleotide transport and metabolism
Specific function:
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
Gene Name:
IMPDH2
Uniprot ID:
Q3SWY3
Molecular weight:
55763.0
General function:
Nucleotide transport and metabolism
Specific function:
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
Gene Name:
IMPDH1
Uniprot ID:
A0JNA3
Molecular weight:
55424.0
General function:
Involved in potassium ion binding
Specific function:
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known.
Gene Name:
ATP1B2
Uniprot ID:
Q28030
Molecular weight:
33401.0
General function:
Involved in potassium ion binding
Specific function:
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known (By similarity).
Gene Name:
ATP1B3
Uniprot ID:
Q3T0C6
Molecular weight:
31521.0
General function:
Involved in ion channel activity
Specific function:
May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.
Gene Name:
FXYD2
Uniprot ID:
Q04645
Molecular weight:
6545.0
General function:
Involved in ATP binding
Specific function:
Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization. Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity). Phosphorylates CDK2AP2 (By similarity). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (By similarity).
Gene Name:
CDK2
Uniprot ID:
Q5E9Y0
Molecular weight:
33873.0
General function:
Posttranslational modification, protein turnover, chaperones
Specific function:
May function as a regulatory ATPase and be related to secretion/protein trafficking process.
Gene Name:
CLPB
Uniprot ID:
Q5E9N5
Molecular weight:
75440.0
General function:
Inorganic ion transport and metabolism
Specific function:
Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX) (By similarity).
Gene Name:
KCNMA1
Uniprot ID:
Q28204
Molecular weight:
130063.0
General function:
Not Available
Specific function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol (By similarity).
Gene Name:
CHRM2
Uniprot ID:
P41985
Molecular weight:
51613.0
General function:
Involved in muscarinic acetylcholine receptor activity
Specific function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Gene Name:
CHRM3
Uniprot ID:
P41984
Molecular weight:
66103.0
General function:
Not Available
Specific function:
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase. May couple to multiple functional responses in cell lines.
Gene Name:
CHRM4
Uniprot ID:
P41986
Molecular weight:
13221.0
General function:
Involved in potassium ion transport
Specific function:
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate (By similarity).
Gene Name:
KCNMB1
Uniprot ID:
Q28067
Molecular weight:
21957.0
General function:
Involved in protein binding
Specific function:
Not Available
Gene Name:
ATP1B1
Uniprot ID:
Q3ZCH8
Molecular weight:
15393.0
General function:
Inorganic ion transport and metabolism
Specific function:
Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (By similarity).
Gene Name:
SLC24A1
Uniprot ID:
Q28139
Molecular weight:
131614.0
General function:
Involved in sodium:potassium-exchanging ATPase activity
Specific function:
May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit (By similarity).
Gene Name:
ATP1B4
Uniprot ID:
A7MB71
Molecular weight:
41473.0
General function:
Involved in sodium:potassium-exchanging ATPase activity
Specific function:
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.
Gene Name:
ATP1B2
Uniprot ID:
A6QLL5
Molecular weight:
33406.0
General function:
Involved in calcium-activated potassium channel activity
Specific function:
Not Available
Gene Name:
KCNN4
Uniprot ID:
Q08D94
Molecular weight:
28582.0
General function:
Energy production and conversion
Specific function:
Not Available
Gene Name:
KCNAB3
Uniprot ID:
A2VDT0
Molecular weight:
43714.0
General function:
Inorganic ion transport and metabolism
Specific function:
Not Available
Gene Name:
KCNK2
Uniprot ID:
Q0VCD1
Molecular weight:
36796.0
General function:
Involved in inward rectifier potassium channel activity
Specific function:
Not Available
Gene Name:
KCNJ12
Uniprot ID:
A2VDS5
Molecular weight:
48461.0
General function:
Inorganic ion transport and metabolism
Specific function:
Not Available
Gene Name:
KCNA2
Uniprot ID:
A6H7J0
Molecular weight:
56747.0
General function:
Involved in protein binding
Specific function:
Not Available
Gene Name:
KCTD18
Uniprot ID:
Q29RJ0
Molecular weight:
46420.0
General function:
Replication, recombination and repair
Specific function:
Not Available
Gene Name:
Kcnma1
Uniprot ID:
Q5G273
Molecular weight:
30153.0
General function:
Involved in potassium ion binding
Specific function:
Not Available
Gene Name:
KCNE1
Uniprot ID:
Q2KHV0
Molecular weight:
14700.0
General function:
Involved in protein binding
Specific function:
Not Available
Gene Name:
KCTD4
Uniprot ID:
A6H6X4
Molecular weight:
29892.0
General function:
Involved in ATP binding
Specific function:
Not Available
Gene Name:
KCNJ11
Uniprot ID:
A2VDS4
Molecular weight:
43294.0
General function:
Inorganic ion transport and metabolism
Specific function:
Not Available
Gene Name:
KCNF1
Uniprot ID:
A4FV89
Molecular weight:
56006.0
General function:
Involved in protein binding
Specific function:
May repress the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent.
Gene Name:
KCTD1
Uniprot ID:
Q2HJ48
Molecular weight:
29334.0
General function:
Replication, recombination and repair
Specific function:
Not Available
Gene Name:
Kcnma1
Uniprot ID:
Q5G272
Molecular weight:
35853.0
General function:
Inorganic ion transport and metabolism
Specific function:
Not Available
Gene Name:
KCNC1
Uniprot ID:
A7E3B1
Molecular weight:
52085.0
General function:
Involved in cyclin-dependent protein kinase inhibitor a
Specific function:
Not Available
Gene Name:
CDKN1B
Uniprot ID:
A6QLS3
Molecular weight:
22090.0
General function:
Carbohydrate transport and metabolism
Specific function:
Not Available
Gene Name:
SK2
Uniprot ID:
Q766U8
Molecular weight:
63858.0
General function:
Involved in inward rectifier potassium channel activity
Specific function:
Not Available
Gene Name:
KCNJ16
Uniprot ID:
Q0VD28
Molecular weight:
47729.0
General function:
Energy production and conversion
Specific function:
Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits (By similarity). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (By similarity). Promotes KCNA4 channel closure (By similarity). Modulates the functional properties of KCNA5 (By similarity). Enhances KCNB2 channel activity (By similarity). Binds NADPH and has NADPH-dependent aldoketoreductase activity (By similarity). Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) (By similarity).
Gene Name:
KCNAB2
Uniprot ID:
Q27955
Molecular weight:
40985.0
General function:
Involved in protein binding
Specific function:
Not Available
Gene Name:
KCTD9
Uniprot ID:
A6QQG5
Molecular weight:
30252.0
General function:
Involved in protein binding
Specific function:
Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex (By similarity). Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4 (By similarity).
Gene Name:
KCTD5
Uniprot ID:
A5PKG7
Molecular weight:
25986.0
General function:
Involved in protein binding
Specific function:
During embryonic development, interferes with neural crest formation. Inhibits AP2 transcriptional activity by interaction with its activation domain (By similarity).
Gene Name:
KCTD15
Uniprot ID:
Q0VD00
Molecular weight:
31885.0

Only showing the first 50 proteins. There are 102 proteins in total.