1.0 2016-09-30 22:44:35 UTC 2020-05-21 16:27:10 UTC BMDB0001352 BMDB01352 Hydroxypyruvic acid Hydroxypyruvic acid, also known as Hydroxypyruvic acid or OH-pyr, belongs to the class of organic compounds known as beta hydroxy acids and derivatives. Beta hydroxy acids and derivatives are compounds containing a carboxylic acid substituted with a hydroxyl group on the C3 carbon atom. Hydroxypyruvic acid is possibly soluble (in water) and an extremely weak basic (essentially neutral) compound (based on its pKa). Hydroxypyruvic acid exists in all living organisms, ranging from bacteria to humans. Hydroxypyruvic acid and L-alanine can be biosynthesized from pyruvic acid and L-serine through its interaction with the enzyme serine--pyruvate aminotransferase. In cattle, hydroxypyruvic acid is involved in the metabolic pathway called the glycine and serine metabolism pathway. 3-Hydroxypyruvate 3-Hydroxypyruvic acid Hydroxypyruvate 3-Hydroxy-2-oxopropanoate 3-Hydroxy-2-oxopropanoic acid beta-Hydroxypyruvate OH-Pyr OH-Pyruvate 2-Oxo-3-hydroxypropanoic acid 2-Oxo-3-hydroxypropionic acid 3-Hydroxy-2-oxopropionic acid Hydroxypyruvic acid beta-Hydroxypyruvic acid β-Hydroxypyruvic acid C3H4O4 104.0615 104.010958616 3-hydroxy-2-oxopropanoic acid hydroxypyruvic acid 1113-60-6 OCC(=O)C(O)=O InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7) HHDDCCUIIUWNGJ-UHFFFAOYSA-N belongs to the class of organic compounds known as beta hydroxy acids and derivatives. Beta hydroxy acids and derivatives are compounds containing a carboxylic acid substituted with a hydroxyl group on the C3 carbon atom. Organic compounds Organic acids and derivatives Hydroxy acids and derivatives Beta hydroxy acids and derivatives Beta hydroxy acids and derivatives Alpha-hydroxy ketones Alpha-keto acids and derivatives Carboxylic acids Hydrocarbon derivatives Monocarboxylic acids and derivatives Monosaccharides Organic oxides Primary alcohols Alcohol Aliphatic acyclic compound Alpha-hydroxy ketone Alpha-keto acid Beta-hydroxy acid Carbonyl group Carboxylic acid Carboxylic acid derivative Hydrocarbon derivative Keto acid Ketone Monocarboxylic acid or derivatives Monosaccharide Organic oxide Organic oxygen compound Organooxygen compound Primary alcohol Aliphatic acyclic compounds 2-oxo monocarboxylic acid 3-hydroxy monocarboxylic acid Solid logp -1.43 ALOGPS logs 0.30 ALOGPS logp -0.75 ChemAxon pka_strongest_acidic 2.57 ChemAxon pka_strongest_basic -3.4 ChemAxon iupac 3-hydroxy-2-oxopropanoic acid ChemAxon average_mass 104.0615 ChemAxon mono_mass 104.010958616 ChemAxon smiles OCC(=O)C(O)=O ChemAxon formula C3H4O4 ChemAxon inchi InChI=1S/C3H4O4/c4-1-2(5)3(6)7/h4H,1H2,(H,6,7) ChemAxon inchikey HHDDCCUIIUWNGJ-UHFFFAOYSA-N ChemAxon polar_surface_area 74.6 ChemAxon refractivity 19.69 ChemAxon polarizability 8.17 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 4 ChemAxon donor_count 2 ChemAxon physiological_charge -1 ChemAxon formal_charge 0 ChemAxon number_of_rings 0 ChemAxon bioavailability 1 ChemAxon rule_of_five Yes ChemAxon ghose_filter Yes ChemAxon veber_rule Yes ChemAxon mddr_like_rule Yes ChemAxon Glycine and Serine Metabolism SMP0087245 Specdb::MsIr 1215 Specdb::MsIr 1216 Specdb::MsIr 1217 Specdb::NmrOneD 147530 Specdb::NmrOneD 147531 Specdb::NmrOneD 147532 Specdb::NmrOneD 147533 Specdb::NmrOneD 147534 Specdb::NmrOneD 147535 Specdb::NmrOneD 147536 Specdb::NmrOneD 147537 Specdb::NmrOneD 147538 Specdb::NmrOneD 147539 Specdb::NmrOneD 147540 Specdb::NmrOneD 147541 Specdb::NmrOneD 147542 Specdb::NmrOneD 147543 Specdb::NmrOneD 147544 Specdb::NmrOneD 147545 Specdb::NmrOneD 147546 Specdb::NmrOneD 147547 Specdb::NmrOneD 147548 Specdb::NmrOneD 147549 Specdb::CMs 987 Specdb::CMs 993 Specdb::CMs 26035 Specdb::CMs 30073 Specdb::CMs 30074 Specdb::CMs 30445 Specdb::CMs 30446 Specdb::CMs 31314 Specdb::CMs 31315 Specdb::CMs 32065 Specdb::CMs 32336 Specdb::CMs 38036 Specdb::CMs 130903 Specdb::CMs 138637 Specdb::MsMs 23711 Specdb::MsMs 23712 Specdb::MsMs 23713 Specdb::MsMs 30509 Specdb::MsMs 30510 Specdb::MsMs 30511 Specdb::MsMs 2245682 Specdb::MsMs 2724749 Specdb::MsMs 2724750 Specdb::MsMs 2724751 Specdb::MsMs 2957085 Specdb::MsMs 2957086 Specdb::MsMs 2957087 Liver 8 multiparous Chinese Holstein dairy cows fed in the Hangzhou Hangjiang Dairy Farm based on the milk production under corn stover based diets. Detection used gas chromatography time-of-flight/mass spectrometry (GC-TOF/MS) platform. Sun HZ, Zhou M, Wang O, Chen Y, Liu JX, Guan LL: Multi-omics reveals functional genomic and metabolic mechanisms of milk production and quality in dairy cows. Bioinformatics. 2020 Apr 15;36(8):2530-2537. doi: 10.1093/bioinformatics/btz951. 31873721 Liver 8 multiparous Chinese Holstein dairy cows fed in the Hangzhou Hangjiang Dairy Farm based on the milk production under alfalfa hay based diets. Detection used gas chromatography time-of-flight/mass spectrometry (GC-TOF/MS) platform. Sun HZ, Zhou M, Wang O, Chen Y, Liu JX, Guan LL: Multi-omics reveals functional genomic and metabolic mechanisms of milk production and quality in dairy cows. Bioinformatics. 2020 Apr 15;36(8):2530-2537. doi: 10.1093/bioinformatics/btz951. 31873721 C00168 FDB030913 939 DB02951 964 30841 C00007563 34120 Hydroxypyruvic_acid 482 OH-PYR Behal, Francis J. Hydroxypyruvic acid formation in Aspergillus niger. Archives of Biochemistry and Biophysics (1960), 88 110-12. BMDBP01367 Serine--pyruvate aminotransferase A7MBF1 AGXT Enzyme