1.0 2016-09-30 23:03:28 UTC 2020-05-21 16:26:51 UTC BMDB0003288 BMDB03288 Selenocysteine Selenocysteine, also known as Selenocysteine, belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom. Selenocysteine is possibly soluble (in water) and a very strong basic compound (based on its pKa). Selenocysteine exists in all living species, ranging from bacteria to humans. Selenocysteine participates in a number of enzymatic reactions, within cattle. In particular, Selenocysteine can be converted into L-alanine and hydrogen selenide; which is mediated by the enzyme selenocysteine lyase. In addition, Selenocysteine and 2-ketobutyric acid can be biosynthesized from selenocystathionine; which is mediated by the enzyme cystathionine gamma-lyase. In cattle, selenocysteine is involved in the metabolic pathway called the selenoamino acid metabolism pathway. 3-Selenyl-L-alanine L-Selenocystein L-Selenozystein (2R)-2-Amino-3-selanylpropanoate (2R)-2-Amino-3-selanylpropanoic acid 3-Seleno-alanine 3-Selenoalanine L-Selenocysteine C3H7NO2Se 168.05 168.964200301 (2R)-2-amino-3-selanylpropanoic acid L-selenocysteine 3614-08-2 N[C@@H](C[SeH])C(O)=O InChI=1S/C3H7NO2Se/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 ZKZBPNGNEQAJSX-REOHCLBHSA-N belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom. Organic compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues L-alpha-amino acids Amino acids Carbonyl compounds Carboxylic acids Hydrocarbon derivatives Monoalkylamines Monocarboxylic acids and derivatives Organic oxides Organopnictogen compounds Selenols Aliphatic acyclic compound Amine Amino acid Carbonyl group Carboxylic acid Hydrocarbon derivative L-alpha-amino acid Monocarboxylic acid or derivatives Organic nitrogen compound Organic oxide Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Organoselenium compound Primary aliphatic amine Primary amine Selenol Aliphatic acyclic compounds L-alanine derivative L-alpha-amino acid Other amino acids proteinogenic amino acid selenocysteine Solid logp -3.20 ALOGPS logs 0.29 ALOGPS logp -4.1 ChemAxon pka_strongest_acidic 1.27 ChemAxon pka_strongest_basic 8.4 ChemAxon iupac (2R)-2-amino-3-selanylpropanoic acid ChemAxon average_mass 168.05 ChemAxon mono_mass 168.964200301 ChemAxon smiles N[C@@H](C[SeH])C(O)=O ChemAxon formula C3H7NO2Se ChemAxon inchi InChI=1S/C3H7NO2Se/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1 ChemAxon inchikey ZKZBPNGNEQAJSX-REOHCLBHSA-N ChemAxon polar_surface_area 63.32 ChemAxon refractivity 33.45 ChemAxon polarizability 10.67 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 4 ChemAxon donor_count 3 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon number_of_rings 0 ChemAxon bioavailability 1 ChemAxon rule_of_five Yes ChemAxon ghose_filter Yes ChemAxon veber_rule Yes ChemAxon mddr_like_rule Yes ChemAxon Selenoamino Acid Metabolism SMP0087161 Specdb::CMs 2681 Specdb::CMs 38562 Specdb::CMs 153066 Specdb::MsMs 29324 Specdb::MsMs 29325 Specdb::MsMs 29326 Specdb::MsMs 35882 Specdb::MsMs 35883 Specdb::MsMs 35884 Specdb::MsMs 2717892 Specdb::MsMs 2717893 Specdb::MsMs 2717894 Specdb::MsMs 2963673 Specdb::MsMs 2963674 Specdb::MsMs 2963675 Specdb::MsIr 1916 Specdb::MsIr 1917 Specdb::MsIr 1918 Specdb::NmrOneD 135550 Specdb::NmrOneD 135551 Specdb::NmrOneD 135552 Specdb::NmrOneD 135553 Specdb::NmrOneD 135554 Specdb::NmrOneD 135555 Specdb::NmrOneD 135556 Specdb::NmrOneD 135557 Specdb::NmrOneD 135558 Specdb::NmrOneD 135559 Specdb::NmrOneD 135560 Specdb::NmrOneD 135561 Specdb::NmrOneD 135562 Specdb::NmrOneD 135563 Specdb::NmrOneD 135564 Specdb::NmrOneD 135565 Specdb::NmrOneD 135566 Specdb::NmrOneD 135567 Specdb::NmrOneD 135568 Specdb::NmrOneD 135569 Fibroblasts Wishart DS, Feunang YD, Marcu A, Guo AC, Liang K, Vazquez-Fresno R, Sajed T, Johnson D, Li C, Karu N, Sayeeda Z, Lo E, Assempour N, Berjanskii M, Singhal S, Arndt D, Liang Y, Badran H, Grant J, Serra-Cayuela A, Liu Y, Mandal R, Neveu V, Pon A, Knox C, Wilson M, Manach C, Scalbert A: HMDB 4.0: the human metabolome database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D608-D617. doi: 10.1093/nar/gkx1089. 29140435 Kidney Wishart DS, Feunang YD, Marcu A, Guo AC, Liang K, Vazquez-Fresno R, Sajed T, Johnson D, Li C, Karu N, Sayeeda Z, Lo E, Assempour N, Berjanskii M, Singhal S, Arndt D, Liang Y, Badran H, Grant J, Serra-Cayuela A, Liu Y, Mandal R, Neveu V, Pon A, Knox C, Wilson M, Manach C, Scalbert A: HMDB 4.0: the human metabolome database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D608-D617. doi: 10.1093/nar/gkx1089. 29140435 Testis Wishart DS, Feunang YD, Marcu A, Guo AC, Liang K, Vazquez-Fresno R, Sajed T, Johnson D, Li C, Karu N, Sayeeda Z, Lo E, Assempour N, Berjanskii M, Singhal S, Arndt D, Liang Y, Badran H, Grant J, Serra-Cayuela A, Liu Y, Mandal R, Neveu V, Pon A, Knox C, Wilson M, Manach C, Scalbert A: HMDB 4.0: the human metabolome database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D608-D617. doi: 10.1093/nar/gkx1089. 29140435 Thyroid Gland Wishart DS, Feunang YD, Marcu A, Guo AC, Liang K, Vazquez-Fresno R, Sajed T, Johnson D, Li C, Karu N, Sayeeda Z, Lo E, Assempour N, Berjanskii M, Singhal S, Arndt D, Liang Y, Badran H, Grant J, Serra-Cayuela A, Liu Y, Mandal R, Neveu V, Pon A, Knox C, Wilson M, Manach C, Scalbert A: HMDB 4.0: the human metabolome database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D608-D617. doi: 10.1093/nar/gkx1089. 29140435 DB02345 FDB002262 23436 C05688 25076 16633 C00034230 L-SELENOCYSTEINE Selenocysteine 46290 3292 BMDBP00391 Ethanolaminephosphotransferase 1 Q17QM4 SELENOI Enzyme BMDBP00501 Thioredoxin reductase 2, mitochondrial Q9N2I8 TXNRD2 Enzyme BMDBP00539 Selenocysteine lyase A2VDS1 SCLY Enzyme BMDBP00540 Thioredoxin reductase 1, cytoplasmic O62768 TXNRD1 Enzyme BMDBP00541 Phospholipid hydroperoxide glutathione peroxidase Q9N2J2 GPX4 Enzyme BMDBP00542 Glutathione peroxidase 3 P37141 GPX3 Enzyme BMDBP00543 Iodothyronine deiodinase Q5I3B0 DIO2 Enzyme BMDBP00544 Glutathione peroxidase 1 P00435 GPX1 Enzyme BMDBP00545 Iodothyronine deiodinase Q9BDR5 Enzyme BMDBP00546 Type II iodothyronine deiodinase Q5I3B2 DIO2 Enzyme BMDBP00547 Methionine-R-sulfoxide reductase B1 Q3MHL9 MSRB1 Enzyme BMDBP00548 Thyroxine 5-deiodinase Q5I3B1 DIO3 Enzyme BMDBP00818 Cystathionine gamma-lyase Q58DW2 CTH Enzyme BMDBP01619 Thioredoxin reductase-like selenoprotein T A6QP01 SELENOT Enzyme BMDBP01620 Selenoprotein S Q2KI76 SELENOS Enzyme BMDBP01621 Selenoprotein P P49907 SELENOP Enzyme BMDBP01622 Selenoprotein K Q32PE3 SELENOK Enzyme BMDBP01623 Selenoprotein F A8YXY3 SELENOF Enzyme