Showing metabocard for DG(18:2(9Z,12Z)/18:2(9Z,12Z)/0:0) (BMDB0007248)

IdentificationTaxonomyPhysical propertiesPathwaysSpectraConcentrationsLinksReferencesenzymes (2) Show 2 proteinsXML
Record Information
Version1.0
Creation Date2016-09-30 23:33:32 UTC
Update Date2020-05-21 16:27:52 UTC
BMDB IDBMDB0007248
Secondary Accession Numbers
  • BMDB07248
Metabolite Identification
Common NameDG(18:2(9Z,12Z)/18:2(9Z,12Z)/0:0)
DescriptionDG(18:2(9Z,12Z)/18:2(9Z,12Z)/0:0), also known as DAG(18:2/18:2) or DAG(18:2OMEGA6/18:2OMEGA6), belongs to the class of organic compounds known as lineolic acids and derivatives. These are derivatives of lineolic acid. Lineolic acid is a polyunsaturated omega-6 18 carbon long fatty acid, with two CC double bonds at the 9- and 12-positions. Thus, DG(18:2(9Z,12Z)/18:2(9Z,12Z)/0:0) is considered to be a diradylglycerol lipid molecule. DG(18:2(9Z,12Z)/18:2(9Z,12Z)/0:0) is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. DG(18:2(9Z,12Z)/18:2(9Z,12Z)/0:0) participates in a number of enzymatic reactions, within cattle. In particular, CDP-Ethanolamine and DG(18:2(9Z,12Z)/18:2(9Z,12Z)/0:0) can be converted into cytidine monophosphate and PE(18:2(9Z,12Z)/18:2(9Z,12Z)); which is catalyzed by the enzyme choline/ethanolaminephosphotransferase. In addition, CDP-Choline and DG(18:2(9Z,12Z)/18:2(9Z,12Z)/0:0) can be converted into cytidine monophosphate and PC(18:2(9Z,12Z)/18:2(9Z,12Z)); which is catalyzed by the enzyme choline/ethanolaminephosphotransferase. In cattle, DG(18:2(9Z,12Z)/18:2(9Z,12Z)/0:0) is involved in the metabolic pathway called phosphatidylcholine biosynthesis PC(18:2(9Z,12Z)/18:2(9Z,12Z)) pathway.
Structure
Thumb
MOLSDFPDBSMILESInChI
Synonyms
ValueSource
(S)-Glyceryl 1,2-dilinoleateChEBI
1,2-Di-(9Z,12Z-octadecadienoyl)-sn-glycerolChEBI
DAG 18:2(omega-6)/18:2(omega-6)/0:0ChEBI
DAG(18:2/18:2)ChEBI
DAG(18:2N6/18:2N6)ChEBI
DAG(18:2OMEGA6/18:2OMEGA6)ChEBI
DAG(36:4)ChEBI
DG(18:2/18:2)ChEBI
DG(18:2/18:2/0:0)ChEBI
DG(18:2N6/18:2N6)ChEBI
DG(18:2OMEGA6/18:2OMEGA6)ChEBI
DG(36:4)ChEBI
Diacylglycerol(18:2/18:2)ChEBI
Diacylglycerol(18:2n6/18:2n6)ChEBI
Diacylglycerol(18:2omega6/18:2omega6)ChEBI
Diacylglycerol(36:4)ChEBI
(S)-Glyceryl 1,2-dilinoleic acidGenerator
1,2-Dilinoleoyl-rac-glycerolHMDB
DAG(18:2W6/18:2W6)HMDB
DG(18:2W6/18:2W6)HMDB
DiacylglycerolHMDB
Diacylglycerol(18:2W6/18:2W6)HMDB
DiglycerideHMDB
1,2-Di(9Z,12Z-octadecadienoyl)-rac-glycerolHMDB
DG(18:2(9Z,12Z)/18:2(9Z,12Z)/0:0)Lipid Annotator
Chemical FormulaC39H68O5
Average Molecular Weight616.9542
Monoisotopic Molecular Weight616.506675286
IUPAC Name(2S)-1-hydroxy-3-[(9Z,12Z)-octadeca-9,12-dienoyloxy]propan-2-yl (9Z,12Z)-octadeca-9,12-dienoate
Traditional Name1,2-dilinoleoyl-sn-glycerol
CAS Registry Number24529-89-3
SMILES
[H][C@](CO)(COC(=O)CCCCCCC\C=C/C\C=C/CCCCC)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC
InChI Identifier
InChI=1S/C39H68O5/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-38(41)43-36-37(35-40)44-39(42)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h11-14,17-20,37,40H,3-10,15-16,21-36H2,1-2H3/b13-11-,14-12-,19-17-,20-18-/t37-/m0/s1
InChI KeyMQGBAQLIFKSMEM-ZHARMHCNSA-N
Chemical Taxonomy
Description belongs to the class of organic compounds known as lineolic acids and derivatives. These are derivatives of lineolic acid. Lineolic acid is a polyunsaturated omega-6 18 carbon long fatty acid, with two CC double bonds at the 9- and 12-positions.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassFatty Acyls
Sub ClassLineolic acids and derivatives
Direct ParentLineolic acids and derivatives
Alternative Parents
Substituents
  • Octadecanoid
  • 1,2-acyl-sn-glycerol
  • Diacylglycerol
  • Diradylglycerol
  • Fatty acid ester
  • Glycerolipid
  • Dicarboxylic acid or derivatives
  • Carboxylic acid ester
  • Carboxylic acid derivative
  • Organooxygen compound
  • Hydrocarbon derivative
  • Organic oxygen compound
  • Organic oxide
  • Carbonyl group
  • Primary alcohol
  • Alcohol
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
StatusExpected but not Quantified
Origin
  • Endogenous
  • Exogenous
BiofunctionNot Available
ApplicationNot Available
Cellular locations
  • Cell membrane
  • Cytoplasm
  • Membrane
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP9.75ALOGPS
logP12.33ChemAxon
logS-7.5ALOGPS
pKa (Strongest Acidic)14.58ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area72.83 ŲChemAxon
Rotatable Bond Count34ChemAxon
Refractivity190.57 m³·mol⁻¹ChemAxon
Polarizability77.66 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash Key
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (1 TMS) - 70eV, Positivesplash10-0pi9-4451947000-6123c6e19b52ca2e1649View in MoNA
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (TBDMS_1_1) - 70eV, PositiveNot AvailableView in JSpectraViewer
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS ("DG(18:2(9Z,12Z)/18:2(9Z,12Z)/0:0),1TMS,#1" TMS) - 70eV, PositiveNot AvailableView in JSpectraViewer
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-001i-0000009000-0033c71a807b4af9c6ccView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-000j-0009063000-2a6cc7367af0f0f532a1View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0019-0009017000-7f8a688ab4bbe576ce48View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-001i-0000009000-7da2b68332eda96bc7ddView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-000j-0009063000-12ce85a2dbd6b233a555View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0019-0009017000-23e58fc626c077fcde5cView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0gdi-2066009000-3bab71571297748c1fdeView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0200-6095000000-a7f010cc595f927100a2View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-004i-2091000000-927ff10a0de90ed7ff9fView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-014i-5496487000-c896e1a4dc6e88df6ad8View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-08fr-4195010000-f0fe8ac9804048da6d7fView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-03di-4495000000-66fee3570bcab9cbb050View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-000i-0000009000-c5201b03fd289f8bd404View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-000i-0000009000-c5201b03fd289f8bd404View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0a4i-0009001000-a548d1db4d72ceec28a0View in MoNA
Biological Properties
Cellular Locations
  • Cell membrane
  • Cytoplasm
  • Membrane
Biospecimen Locations
  • All Tissues
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
All TissuesExpected but not QuantifiedNot QuantifiedNot SpecifiedNot SpecifiedNormal
  • Not Applicable
 details
Abnormal Concentrations
Not Available
HMDB IDHMDB0007248
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB024441
KNApSAcK IDNot Available
Chemspider ID7822679
KEGG Compound IDC00165
BioCyc IDDIACYLGLYCEROL
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN ID4371
PubChem Compound9543729
PDB IDNot Available
ChEBI ID77127
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available

Enzymes

Enzyme Details
1. Ethanolaminephosphotransferase 1
General function:
Involved in ethanolaminephosphotransferase activity
Specific function:
Catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the foramtion of phosphatidylethanolamine via 'Kennedy' pathway (By similarity).
Gene Name:
SELENOI
Uniprot ID:
Q17QM4
Molecular weight:
45214.0
Reactions
CDP-Ethanolamine + DG(18:2(9Z,12Z)/18:2(9Z,12Z)/0:0) → Cytidine monophosphate + PE(18:2(9Z,12Z)/18:2(9Z,12Z))details
Enzyme Details
2. Diacylglycerol O-acyltransferase 1
General function:
Not Available
Specific function:
Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders. In liver, plays a role in esterifying exogenous fatty acids to glycerol.
Gene Name:
DGAT1
Uniprot ID:
Q8MK44
Molecular weight:
55602.0
Reactions
DG(18:2(9Z,12Z)/18:2(9Z,12Z)/0:0) + Gamma-linolenoyl-CoA → TG(18:2(9Z,12Z)/18:2(9Z,12Z)/18:3(6Z,9Z,12Z)) + Coenzyme Adetails
DG(18:2(9Z,12Z)/18:2(9Z,12Z)/0:0) + Eicosanoyl-CoA → TG(18:2(9Z,12Z)/18:2(9Z,12Z)/20:0) + Coenzyme Adetails
DG(18:2(9Z,12Z)/18:2(9Z,12Z)/0:0) + Gondoyl-CoA → TG(18:2(9Z,12Z)/18:2(9Z,12Z)/20:1(11Z)) + Coenzyme Adetails
DG(18:2(9Z,12Z)/18:2(9Z,12Z)/0:0) + 5Z,8Z,11Z,14Z-eicosatetraenonyl-CoA → TG(18:2(9Z,12Z)/18:2(9Z,12Z)/20:4(5Z,8Z,11Z,14Z)) + Coenzyme Adetails
DG(18:2(9Z,12Z)/18:2(9Z,12Z)/0:0) + Docosanoyl-CoA → TG(18:2(9Z,12Z)/18:2(9Z,12Z)/22:0) + Coenzyme Adetails
DG(18:2(9Z,12Z)/18:2(9Z,12Z)/0:0) + Erucoyl-CoA → TG(18:2(9Z,12Z)/18:2(9Z,12Z)/22:1(13Z)) + Coenzyme Adetails
DG(18:2(9Z,12Z)/18:2(9Z,12Z)/0:0) + Clupanodonyl CoA → TG(18:2(9Z,12Z)/18:2(9Z,12Z)/22:5(7Z,10Z,13Z,16Z,19Z)) + Coenzyme Adetails