Showing metabocard for PE(18:0/18:1(9Z)) (BMDB0008993)

IdentificationTaxonomyPhysical propertiesPathwaysSpectraConcentrationsLinksReferencesenzymes (2) Show 2 proteinsXML
Record Information
Version1.0
Creation Date2016-10-03 17:33:35 UTC
Update Date2020-05-21 16:28:14 UTC
BMDB IDBMDB0008993
Secondary Accession Numbers
  • BMDB08993
Metabolite Identification
Common NamePE(18:0/18:1(9Z))
DescriptionPE(18:0/18:1(9Z)), also known as pe(18:0/18:1(9z)) or PE(36:1), belongs to the class of organic compounds known as phosphatidylethanolamines. These are glycerophosphoetahnolamines in which two fatty acids are bonded to the glycerol moiety through ester linkages. Thus, PE(18:0/18:1(9Z)) is considered to be a glycerophosphoethanolamine lipid molecule. PE(18:0/18:1(9Z)) is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. PE(18:0/18:1(9Z)) exists in all living species, ranging from bacteria to humans. PE(18:0/18:1(9Z)) participates in a number of enzymatic reactions, within cattle. In particular, PE(18:0/18:1(9Z)) can be biosynthesized from PS(18:0/18:1(9Z)) through its interaction with the enzyme phosphatidylserine decarboxylase. In addition, Cytidine monophosphate and PE(18:0/18:1(9Z)) can be biosynthesized from CDP-ethanolamine and DG(18:0/18:1(9Z)/0:0) through its interaction with the enzyme choline/ethanolaminephosphotransferase. In cattle, PE(18:0/18:1(9Z)) is involved in the metabolic pathway called phosphatidylethanolamine biosynthesis pe(18:0/18:1(9Z)) pathway.
Structure
Thumb
MOLSDFPDBSMILESInChI
Synonyms
ValueSource
1-Octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamineChEBI
1-Octadecanoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine zwitterionChEBI
1-Stearoyl-2-oleoyl-gpeChEBI
1-Stearoyl-2-oleoyl-gpe (18:0/18:1)ChEBI
2-Azaniumylethyl (2R)-2-[(9Z)-octadec-9-enoyloxy]-3-(stearoyloxy)propyl phosphateChEBI
GPE(18:0/18:1)ChEBI
PE 18:0/18:1(omega-9)ChEBI
2-Azaniumylethyl (2R)-2-[(9Z)-octadec-9-enoyloxy]-3-(stearoyloxy)propyl phosphoric acidGenerator
GPEtn(18:0/18:1)HMDB
PE(36:1)HMDB
Phophatidylethanolamine(36:1)HMDB
1-Stearoyl-2-oleoyl-sn-glycero-3-phosphoethanolamineHMDB
PE(18:0/18:1)HMDB
GPEtn(36:1)HMDB
1-Octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineHMDB
Phophatidylethanolamine(18:0/18:1)HMDB
1-Stearoyl-2-oleoyl-phosphatidyethanolamineHMDB
1-Stearoyl-2-oleoyl-sn-glycero-phosphatidylethanolamineHMDB
1-Stearoyl-2-oleoyl-sn-glycerol-3-phosphoethanolamineHMDB
1-Stearoyl-2-oleoylglycero-3-phosphorylethanolamineHMDB
1-Stearoyl-2-oleoylphosphatidylethanolamineHMDB
GPE(18:0/18:1(9Z))HMDB
GPE(18:0/18:1n9)HMDB
GPE(18:0/18:1W9)HMDB
GPE(36:1)HMDB
GPEtn(18:0/18:1(9Z))HMDB
GPEtn(18:0/18:1n9)HMDB
GPEtn(18:0/18:1W9)HMDB
PE(18:0/18:1N9)HMDB
PE(18:0/18:1W9)HMDB
Phosphatidylethanolamine(18:0/18:1(9Z))HMDB
Phosphatidylethanolamine(18:0/18:1)HMDB
Phosphatidylethanolamine(18:0/18:1n9)HMDB
Phosphatidylethanolamine(18:0/18:1W9)HMDB
Phosphatidylethanolamine(36:1)HMDB
SOPEHMDB
PE(18:0/18:1(9Z))Lipid Annotator
Chemical FormulaC41H80NO8P
Average Molecular Weight746.064
Monoisotopic Molecular Weight745.562155538
IUPAC Name(2-aminoethoxy)[(2R)-2-[(9Z)-octadec-9-enoyloxy]-3-(octadecanoyloxy)propoxy]phosphinic acid
Traditional Name2-aminoethoxy((2R)-2-[(9Z)-octadec-9-enoyloxy]-3-(octadecanoyloxy)propoxy)phosphinic acid
CAS Registry NumberNot Available
SMILES
[H][C@@](COC(=O)CCCCCCCCCCCCCCCCC)(COP(O)(=O)OCCN)OC(=O)CCCCCCC\C=C/CCCCCCCC
InChI Identifier
InChI=1S/C41H80NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(43)47-37-39(38-49-51(45,46)48-36-35-42)50-41(44)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h18,20,39H,3-17,19,21-38,42H2,1-2H3,(H,45,46)/b20-18-/t39-/m1/s1
InChI KeyJQKOHRZNEOQNJE-DJEJVYNPSA-N
Chemical Taxonomy
Description belongs to the class of organic compounds known as phosphatidylethanolamines. These are glycerophosphoetahnolamines in which two fatty acids are bonded to the glycerol moiety through ester linkages.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassGlycerophospholipids
Sub ClassGlycerophosphoethanolamines
Direct ParentPhosphatidylethanolamines
Alternative Parents
Substituents
  • Diacylglycero-3-phosphoethanolamine
  • Phosphoethanolamine
  • Fatty acid ester
  • Dialkyl phosphate
  • Dicarboxylic acid or derivatives
  • Organic phosphoric acid derivative
  • Phosphoric acid ester
  • Alkyl phosphate
  • Fatty acyl
  • Amino acid or derivatives
  • Carboxylic acid ester
  • Carboxylic acid derivative
  • Organopnictogen compound
  • Organic oxygen compound
  • Organooxygen compound
  • Organonitrogen compound
  • Amine
  • Primary aliphatic amine
  • Organic nitrogen compound
  • Primary amine
  • Carbonyl group
  • Organic oxide
  • Hydrocarbon derivative
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
StatusExpected but not Quantified
Origin
  • Endogenous
  • Exogenous
BiofunctionNot Available
ApplicationNot Available
Cellular locations
  • Cell membrane
  • Intracellular membrane
  • Membrane
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP8.83ALOGPS
logP11.87ChemAxon
logS-7.1ALOGPS
pKa (Strongest Acidic)1.87ChemAxon
pKa (Strongest Basic)10ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area134.38 ŲChemAxon
Rotatable Bond Count42ChemAxon
Refractivity210.52 m³·mol⁻¹ChemAxon
Polarizability92.13 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash Key
Predicted GC-MSPredicted GC-MS Spectrum - GC-MS (TMS_1_1) - 70eV, PositiveNot AvailableView in JSpectraViewer
LC-MS/MSLC-MS/MS Spectrum - DI-ESI-qTof , Positivesplash10-004i-0002349700-ec82ed0595ac526a01dfView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0006-0030000900-e1433848e477fac7af44View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0006-0030000900-e1433848e477fac7af44View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-001i-0190300300-fefe4f5fc193387aa4c1View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0002-0000001900-7176fc363ec50a2c3ca5View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0a4j-0003609700-dc3a90d8c00fc700c19eView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0a4i-0003609300-df188d78672ea420fee7View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0006-0030000900-d7cda9257d10bafa2de3View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0006-0030000900-d7cda9257d10bafa2de3View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-001i-0190300300-1b7bf283e64a78c2f788View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0002-0000001900-f16c013a0ef8ad1e73b0View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0a4j-0003609700-811a9e21167adc7d820eView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0a4i-0003609300-af7611beccef54e97695View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-014i-0000001900-5c10bab26c2e0a3f80b0View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-016r-0000001900-607ffbebec54dace7f08View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-004i-0100201900-5f19400f5578875416d7View in MoNA
Biological Properties
Cellular Locations
  • Cell membrane
  • Intracellular membrane
  • Membrane
Biospecimen Locations
  • All Tissues
  • Brain
  • Placenta
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
All TissuesExpected but not QuantifiedNot QuantifiedNot SpecifiedNot SpecifiedNormal
  • Not Applicable
 details
BrainExpected but not QuantifiedNot QuantifiedNot SpecifiedNot SpecifiedNormal
  • Not Applicable
 details
PlacentaExpected but not QuantifiedNot QuantifiedNot SpecifiedNot SpecifiedNormal
  • Not Applicable
 details
Abnormal Concentrations
Not Available
HMDB IDHMDB0008993
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB026183
KNApSAcK IDNot Available
Chemspider IDNot Available
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound9546742
PDB IDNot Available
ChEBI ID75038
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available

Enzymes

Enzyme Details
1. Ethanolaminephosphotransferase 1
General function:
Involved in ethanolaminephosphotransferase activity
Specific function:
Catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the foramtion of phosphatidylethanolamine via 'Kennedy' pathway (By similarity).
Gene Name:
SELENOI
Uniprot ID:
Q17QM4
Molecular weight:
45214.0
Reactions
CDP-Ethanolamine + DG(18:0/18:1(9Z)/0:0) → Cytidine monophosphate + PE(18:0/18:1(9Z))details
Enzyme Details
2. Phosphatidylserine decarboxylase proenzyme, mitochondrial
General function:
Not Available
Specific function:
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
Gene Name:
PISD
Uniprot ID:
Q58DH2
Molecular weight:
47244.0
Reactions
PS(18:0/18:1(9Z)) → PE(18:0/18:1(9Z)) + Carbon dioxidedetails