Bovine Metabolome Database: Showing metabocard for LysoPC(18:0/0:0) (BMDB0010384)

Identification Taxonomy Physical properties Pathways Spectra Concentrations Links References XML

Record Information

Version

1.0

Creation Date

2016-10-03 18:05:32 UTC

Update Date

2020-06-04 20:09:23 UTC

BMDB ID

BMDB0010384

Secondary Accession Numbers

BMDB0062739
BMDB10384
BMDB62739

Metabolite Identification

Common Name

LysoPC(18:0/0:0)

Description

LysoPC(18:0/0:0) is a lysophospholipid (LyP). It is a monoglycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. LysoPC(18:0/0:0), in particular, consists of one octadecanoyl chain. Lysophosphatidylcholines can have different combinations of fatty acids of varying lengths and saturation attached at the C-1 (sn-1) position. Fatty acids containing 16, 18 and 20 carbons are the most common. LysoPC(20:3(5Z,8Z,11Z)), in particular, consists of one chain of mead acid at the C-1 position. The mead acid moiety is derived from fish oils, liver and kidney. Lysophosphatidylcholine is found in small amounts in most tissues. It is formed by hydrolysis of phosphatidylcholine by the enzyme phospholipase A2, as part of the de-acylation/re-acylation cycle that controls its overall molecular species composition. It can also be formed inadvertently during extraction of lipids from tissues if the phospholipase is activated by careless handling.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
(2R)-2-Hydroxy-3-(stearoyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate	ChEBI
1-O-Stearoyl-sn-glycero-3-phosphocholine	ChEBI
1-Octadecanoyl-sn-glycero-3-phosphocholine	ChEBI
1-Stearoyl-glycero-3-phosphocholine	ChEBI
1-Stearoylglycerophosphocholine (18:0)	ChEBI
1-Stearoylglycerophosphocholine(18:0)	ChEBI
18:0 LYSO-PC	ChEBI
GPCho 18:0/0:0	ChEBI
GPCho(18:0/0:0)	ChEBI
LPC 18:0/0:0	ChEBI
LPC(18:0)	ChEBI
LPC(18:0/0:0)	ChEBI
LysoPC 18:0/0:0	ChEBI
LysoPC(18:0)	ChEBI
Lysophosphatidylcholine (18:0/0:0)	ChEBI
Lysophosphatidylcholine(18:0)	ChEBI
Lysophosphatidylcholine(18:0/0:0)	ChEBI
PC 18:0/0:0	ChEBI
PC(18:0/0:0)	ChEBI
(2R)-2-Hydroxy-3-(stearoyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphoric acid	Generator
LyPC(18:0)	HMDB
LyPC(18:0/0:0)	HMDB
LysoPC a C18:0	HMDB
Stearoyl alpha-lysolecithin	HMDB
Stearoyllysophosphatidylcholine	HMDB
1-Octadecyl-glycero-3-phosphocholine	HMDB
1-Stearoyl-sn-glycero-3-phosphorylcholine	HMDB
Stearoyl L-alpha-lysolecithin	HMDB
1-Stearoyl-2-hydroxy-sn-glycero-3-phosphocholine	HMDB
Stearoyl alpha-lysolecithin, (+-)-isomer	HMDB
Stearoyl alpha-lysolecithin, (R)-isomer	HMDB
1-Octadecanoyl-glycero-3-phosphocholine	HMDB
1-Octadecanoylglycerophosphocholine	HMDB
1-Octadecylglycerophosphocholine	HMDB
1-Stearoylglycerophosphocholine	HMDB
1-O-Stearoyl-2-lyso-sn-glycero-3-phosphocholine	HMDB
1-Octadecanoyl-3-glycerophosphorylcholine	HMDB
1-Octadecanoyl-sn-glycerol-3-phosphorylcholine	HMDB
1-Octadecanoyllysolecithin	HMDB
1-Stearoyl-2-lysophosphatidylcholine	HMDB
1-Stearoyl-3-glycerylphosphorylcholine	HMDB
1-Stearoyl-GPC	HMDB
1-Stearoyl-lysophosphatidylcholine	HMDB
1-Stearoyl-sn-glycero-3-phosphocholine	HMDB
1-Stearoyl-sn-glycerol-3-phosphatidylcholine	HMDB
1-Stearoyl-sn-glycerol-3-phosphorylcholine	HMDB
1-Stearoylglycero-3-phosphorylcholine	HMDB
1-Stearoyllysophosphatidylcholine	HMDB
GPC(18:0)	HMDB
GPC(18:0/0:0)	HMDB
Lysophosphatidylcholine C18:0	HMDB
Stearoyl L-α-lysolecithin	HMDB
Stearoyl lysolecithin	HMDB
Stearoyl lysophosphatidylcholine	HMDB
LysoPC(18:0/0:0)	Lipid Annotator, ChEBI

Chemical Formula

C₂₆H₅₄NO₇P

Average Molecular Weight

523.6832

Monoisotopic Molecular Weight

523.363789599

IUPAC Name

(2-{[(2R)-2-hydroxy-3-(octadecanoyloxy)propyl phosphono]oxy}ethyl)trimethylazanium

Traditional Name

(2-{[(2R)-2-hydroxy-3-(octadecanoyloxy)propyl phosphono]oxy}ethyl)trimethylazanium

CAS Registry Number

5655-17-4

SMILES

[H][C@@](O)(COC(=O)CCCCCCCCCCCCCCCCC)COP([O-])(=O)OCC[N+](C)(C)C

InChI Identifier

InChI=1S/C26H54NO7P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-26(29)32-23-25(28)24-34-35(30,31)33-22-21-27(2,3)4/h25,28H,5-24H2,1-4H3/t25-/m1/s1

InChI Key

IHNKQIMGVNPMTC-RUZDIDTESA-N

Chemical Taxonomy

Description

belongs to the class of organic compounds known as 1-acyl-sn-glycero-3-phosphocholines. These are glycerophosphocholines in which the glycerol is esterified with a fatty acid at O-1 position, and linked at position 3 to a phosphocholine.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Glycerophospholipids

Sub Class

Glycerophosphocholines

Direct Parent

1-acyl-sn-glycero-3-phosphocholines

Alternative Parents

Substituents

1-acyl-sn-glycero-3-phosphocholine
Phosphocholine
Fatty acid ester
Dialkyl phosphate
Organic phosphoric acid derivative
Phosphoric acid ester
Alkyl phosphate
Fatty acyl
Tetraalkylammonium salt
Quaternary ammonium salt
Secondary alcohol
Carboxylic acid ester
Carboxylic acid derivative
Monocarboxylic acid or derivatives
Organic oxide
Organooxygen compound
Organonitrogen compound
Organic nitrogen compound
Alcohol
Organic oxygen compound
Organopnictogen compound
Carbonyl group
Organic salt
Amine
Hydrocarbon derivative
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

1-O-acyl-sn-glycero-3-phosphocholine (CHEBI:73858 )
lysophosphatidylcholine 18:0 (CHEBI:73858 )
Monoacylglycerophosphocholines (LMGP01050026 )

Ontology

Status

Detected and Quantified

Origin

Endogenous

Exogenous

Biofunction

Not Available

Application

Not Available

Cellular locations

Cell membrane
Intracellular membrane
Membrane

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	2.53	ALOGPS
logP	2.08	ChemAxon
logS	-6.4	ALOGPS
pKa (Strongest Acidic)	1.86	ChemAxon
pKa (Strongest Basic)	-3.4	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	105.12 Å²	ChemAxon
Rotatable Bond Count	26	ChemAxon
Refractivity	151.48 m³·mol⁻¹	ChemAxon
Polarizability	61.71 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	Yes	ChemAxon

Spectra

Biological Properties

Cellular Locations

Cell membrane
Intracellular membrane
Membrane

Biospecimen Locations

All Tissues
Blood
Liver
Longissimus Thoracis Muscle
Placenta
Ruminal Fluid
Semimembranosus Muscle
Testis

Pathways

Not Available

Name	SMPDB/Pathwhiz	KEGG

Normal Concentrations

Biospecimen	Status	Value	Age	Sex	Condition	Reference	Details
All Tissues	Expected but not Quantified	Not Quantified	Not Specified	Not Specified	Normal	Not Applicable	details
Blood	Detected and Quantified	30 +/- 5 uM	Not Specified	Not Specified	Normal	Aidin Foroutan, C...	details
Blood	Detected but not Quantified	Not Quantified	Not Specified	Not Specified	Normal	PMID: 24630653	details
Blood	Detected and Quantified	14-82 uM	Not Specified	Not Specified	Normal	PMID: 25157578	details
Liver	Detected and Quantified	2.1 +/- 0.4 nmol/g of tissue	Not Specified	Not Specified	Normal	Aidin Foroutan, C...	details
Liver	Detected but not Quantified	Not Quantified	Not Specified	Not Specified	Normal	PMID: 31867104	details
Longissimus Thoracis Muscle	Detected and Quantified	0.07 +/- 0.02 nmol/g of tissue	Not Specified	Not Specified	Normal	Aidin Foroutan, C...	details
Placenta	Expected but not Quantified	Not Quantified	Not Specified	Not Specified	Normal	Not Applicable	details
Ruminal Fluid	Detected and Quantified	0.2 +/- 0.1 uM	Not Specified	Not Specified	Normal	Aidin Foroutan, C...	details
Ruminal Fluid	Detected and Quantified	0.11 +/- 0.02 uM	Not Specified	Not Specified	Normal	Fozia Saleem, Sou...	details
Ruminal Fluid	Detected and Quantified	0.11 +/- 0.02 uM	Not Specified	Not Specified	Normal	Fozia Saleem, Sou...	details
Semimembranosus Muscle	Detected and Quantified	0.08 +/- 0.03 nmol/g of tissue	Not Specified	Not Specified	Normal	Aidin Foroutan, C...	details
Testis	Detected and Quantified	0.16 +/- 0.03 nmol/g of tissue	Not Specified	Not Specified	Normal	Aidin Foroutan, C...	details

Abnormal Concentrations

Not Available

External Links

HMDB ID

HMDB0010384

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

FDB027535

KNApSAcK ID

Not Available

Chemspider ID

435389

KEGG Compound ID

C04230

BioCyc ID

CPD-8345

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

497299

PDB ID

Not Available

ChEBI ID

73858

References

Synthesis Reference

Not Available

Material Safety Data Sheet (MSDS)

Not Available

General References

A. Foroutan et al. (2019). A. Foroutan et al. The Chemical Composition of Commercial Cow's Milk (in preparation). Journal of Agricultural and Food Chemistry.

Showing metabocard for LysoPC(18:0/0:0) (BMDB0010384)

Structure for BMDB0010384 (LysoPC(18:0/0:0))