| Record Information |
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| Version | 1.0 |
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| Creation Date | 2016-10-03 18:18:27 UTC |
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| Update Date | 2020-05-11 19:52:18 UTC |
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| BMDB ID | BMDB0011437 |
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| Secondary Accession Numbers | |
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| Metabolite Identification |
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| Common Name | PE(P-18:1(9Z)/16:0) |
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| Description | PE(P-18:1(9Z)/16:0) is a phosphatidylethanolamine. It is a glycerophospholipid in which a phosphorylethanolamine moiety occupies a glycerol substitution site. As is the case with diacylglycerols, glycerophosphoethanolamines can have many different combinations of fatty acids of varying lengths and saturation attached to the C-1 and C-2 atoms. PE(P-18:1(9Z)/16:0), in particular, consists of one 1Z,9Z-octadecadienyl chain to the C-1 atom, and one hexadecanoyl to the C-2 atom. While most phospholipids have a saturated fatty acid on C-1 and an unsaturated fatty acid on C-2 of the glycerol backbone, the fatty acid distribution at the C-1 and C-2 positions of glycerol within phospholipids is continually in flux, owing to phospholipid degradation and the continuous phospholipid remodeling that occurs while these molecules are in membranes. PEs are neutral zwitterions at physiological pH. They mostly have palmitic or stearic acid on carbon 1 and a long chain unsaturated fatty acid (e.g. 18:2, 20:4 and 22:6) on carbon 2. PE synthesis can occur via two pathways. The first requires that ethanolamine be activated by phosphorylation and then coupled to CDP. The ethanolamine is then transferred from CDP-ethanolamine to phosphatidic acid to yield PE. The second involves the decarboxylation of PS. |
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| Structure | |
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| Synonyms | | Value | Source |
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| 1-(1-Enyl-oleoyl)-2-palmitoyl-sn-glycero-3-phosphoethanolamine | HMDB | | (2-Aminoethoxy)[(2R)-2-(hexadecanoyloxy)-3-[(1Z,9Z)-octadeca-1,9-dien-1-yloxy]propoxy]phosphinate | Generator, HMDB | | 1-(1Z,9Z-Octadecadienyl)-2-palmitoyl-gpe | HMDB | | 1-(1Z,9Z-Octadecadienyl)-2-palmitoyl-sn-glycero-3-phosphoethanolamine | HMDB | | 1-(1Z,9Z-Octadecadienyl)-2-palmitoyl-sn-glycero-phosphatidylethanolamine | HMDB | | GPE(18:2/16:0) | HMDB | | GPE(34:2) | HMDB | | GPE(O-18:2(1Z,9Z)/16:0) | HMDB | | GPE(p-18:1(9Z)/16:0) | HMDB | | GPEtn(18:2/16:0) | HMDB | | GPEtn(34:2) | HMDB | | GPEtn(O-18:2(1Z,9Z)/16:0) | HMDB | | GPEtn(p-18:1(9Z)/16:0) | HMDB | | PE(18:2/16:0) | HMDB | | PE(34:2) | HMDB | | PE(O-18:2(1Z,9Z)/16:0) | HMDB | | Phosphatidylethanolamine(18:2/16:0) | HMDB | | Phosphatidylethanolamine(34:2) | HMDB | | Phosphatidylethanolamine(O-18:2(1Z,9Z)/16:0) | HMDB | | Phosphatidylethanolamine(p-18:1(9Z)/16:0) | HMDB |
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| Chemical Formula | C39H76NO7P |
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| Average Molecular Weight | 701.997 |
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| Monoisotopic Molecular Weight | 701.535940303 |
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| IUPAC Name | (2-aminoethoxy)[(2R)-2-(hexadecanoyloxy)-3-[(1Z,9Z)-octadeca-1,9-dien-1-yloxy]propoxy]phosphinic acid |
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| Traditional Name | 2-aminoethoxy(2R)-2-(hexadecanoyloxy)-3-[(1Z,9Z)-octadeca-1,9-dien-1-yloxy]propoxyphosphinic acid |
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| CAS Registry Number | Not Available |
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| SMILES | [H][C@@](CO\C=C/CCCCCC\C=C/CCCCCCCC)(COP(O)(=O)OCCN)OC(=O)CCCCCCCCCCCCCCC |
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| InChI Identifier | InChI=1S/C39H76NO7P/c1-3-5-7-9-11-13-15-17-18-19-21-23-25-27-29-31-34-44-36-38(37-46-48(42,43)45-35-33-40)47-39(41)32-30-28-26-24-22-20-16-14-12-10-8-6-4-2/h17-18,31,34,38H,3-16,19-30,32-33,35-37,40H2,1-2H3,(H,42,43)/b18-17-,34-31-/t38-/m1/s1 |
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| InChI Key | ZOSSFCIAXYNTHL-CSTBBDSDSA-N |
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| Chemical Taxonomy |
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| Description | belongs to the class of organic compounds known as 1-(1z-alkenyl),2-acylglycerophosphoethanolamines. These are glycerophosphoethanolamines that carry exactly one acyl chain attached to the glycerol moiety through an ester linkage at the O2-position, and one 1Z-alkenyl chain attached through an ether linkage at the O1-position. |
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| Kingdom | Organic compounds |
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| Super Class | Lipids and lipid-like molecules |
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| Class | Glycerophospholipids |
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| Sub Class | Glycerophosphoethanolamines |
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| Direct Parent | 1-(1Z-alkenyl),2-acylglycerophosphoethanolamines |
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| Alternative Parents | |
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| Substituents | - 1-(1z-alkenyl),2-acylglycerophosphoethanolamine
- Glycerol vinyl ether
- Phosphoethanolamine
- Fatty acid ester
- Dialkyl phosphate
- Fatty acyl
- Alkyl phosphate
- Organic phosphoric acid derivative
- Phosphoric acid ester
- Amino acid or derivatives
- Carboxylic acid ester
- Carboxylic acid derivative
- Monocarboxylic acid or derivatives
- Organic oxide
- Organooxygen compound
- Organonitrogen compound
- Organic nitrogen compound
- Primary amine
- Primary aliphatic amine
- Organic oxygen compound
- Amine
- Carbonyl group
- Organopnictogen compound
- Hydrocarbon derivative
- Aliphatic acyclic compound
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| Molecular Framework | Aliphatic acyclic compounds |
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| External Descriptors | Not Available |
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| Ontology |
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| Status | Expected but not Quantified |
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| Origin | |
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| Biofunction | Not Available |
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| Application | Not Available |
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| Cellular locations | - Cell membrane
- Intracellular membrane
- Membrane
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| Physical Properties |
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| State | Solid |
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| Experimental Properties | | Property | Value | Reference |
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| Melting Point | Not Available | Not Available | | Boiling Point | Not Available | Not Available | | Water Solubility | Not Available | Not Available | | LogP | Not Available | Not Available |
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| Predicted Properties | |
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| Spectra |
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| Spectra | |
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