1.0 2018-10-03 16:33:40 UTC 2020-06-04 18:57:22 UTC BMDB0063615 BMDB63615 p,p′-DDE 1,1-Dichloro-2,2-bis(p-chlorophenyl) ethylene (DDE) is a breakdown product of DDT, which was used in the past as an insecticide. No information is available on the acute (short-term) or chronic (long-term) effects of DDE. Acute, oral exposure to high doses of DDT in humans results in central nervous system (CNS) effects, such as headaches, nausea, and convulsions. The only effect noted in epidemiologic studies of workers exposed to DDT and other pesticides was an increase in activity of liver enzymes. Animal studies have reported effects on the liver, immune system, and CNS from chronic oral exposure to DDT. Human studies are inconclusive regarding DDE and cancer. Animal studies have reported an increased incidence of liver tumors in mice and hamsters, and thyroid tumors in female rats from oral exposure to DDE. EPA has classified DDE as a Group B2, probable human carcinogen. 1,1-Dichloro-2,2-bis(4'-chlorophenyl)ethylene 1,1-Dichloro-2,2-bis(4-chlorophenyl)ethylene 4,4'-DDE p,P'-(dichlorodiphenyl)-2,2-dichloroethylene p,P'-dde DDE 1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene DDMU DDX Dichlorodiphenyl dichloroethylene Dichloroethylene, dichlorodiphenyl p,p-Dichlorodiphenyldichloroethylene C14H8Cl4 318.025 315.938011084 1-chloro-4-[2,2-dichloro-1-(4-chlorophenyl)ethenyl]benzene p,p'-DDE 72-55-9 ClC(Cl)=C(C1=CC=C(Cl)C=C1)C1=CC=C(Cl)C=C1 InChI=1S/C14H8Cl4/c15-11-5-1-9(2-6-11)13(14(17)18)10-3-7-12(16)8-4-10/h1-8H UCNVFOCBFJOQAL-UHFFFAOYSA-N belongs to the class of organic compounds known as diphenylmethanes. Diphenylmethanes are compounds containing a diphenylmethane moiety, which consists of a methane wherein two hydrogen atoms are replaced by two phenyl groups. Organic compounds Benzenoids Benzene and substituted derivatives Diphenylmethanes Diphenylmethanes Aryl chlorides Chloroalkenes Chlorobenzenes Hydrocarbon derivatives Ketene acetals Organochlorides Vinyl chlorides Aromatic homomonocyclic compound Aryl chloride Aryl halide Chloroalkene Chlorobenzene Diphenylmethane Haloalkene Halobenzene Hydrocarbon derivative Ketene acetal or derivatives Organochloride Organohalogen compound Vinyl chloride Vinyl halide Aromatic homomonocyclic compounds Organochlorine pesticides a small molecule chlorophenylethylene monochlorobenzenes logp 6.22 ALOGPS logs -6.64 ALOGPS logp 6.11 ChemAxon iupac 1-chloro-4-[2,2-dichloro-1-(4-chlorophenyl)ethenyl]benzene ChemAxon average_mass 318.025 ChemAxon mono_mass 315.938011084 ChemAxon smiles ClC(Cl)=C(C1=CC=C(Cl)C=C1)C1=CC=C(Cl)C=C1 ChemAxon formula C14H8Cl4 ChemAxon inchi InChI=1S/C14H8Cl4/c15-11-5-1-9(2-6-11)13(14(17)18)10-3-7-12(16)8-4-10/h1-8H ChemAxon inchikey UCNVFOCBFJOQAL-UHFFFAOYSA-N ChemAxon polar_surface_area 0 ChemAxon refractivity 99.31 ChemAxon polarizability 30.79 ChemAxon rotatable_bond_count 2 ChemAxon acceptor_count 0 ChemAxon donor_count 0 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon number_of_rings 2 ChemAxon bioavailability 1 ChemAxon rule_of_five Yes ChemAxon ghose_filter Yes ChemAxon veber_rule Yes ChemAxon mddr_like_rule Yes ChemAxon Specdb::EiMs 1027 Specdb::MsMs 83259 Specdb::MsMs 83260 Specdb::MsMs 83261 Specdb::MsMs 144816 Specdb::MsMs 144817 Specdb::MsMs 144818 Specdb::MsMs 3610456 Specdb::MsMs 3610457 Specdb::MsMs 3610458 Specdb::MsMs 3610459 Specdb::MsMs 3610460 Specdb::MsMs 3610461 Specdb::NmrOneD 2596 Specdb::NmrOneD 3299 Milk 0.0641 +/- 0.0830 uM Raw bovine milk from Haryana (n=147) Sharma HR, Kaushik A, Kaushik CP: Pesticide residues in bovine milk from a predominantly agricultural state of Haryana, India. Environ Monit Assess. 2007 Jun;129(1-3):349-57. doi: 10.1007/s10661-006-9368-5. Epub 2006 Dec 16. 17180431 FDB097419 2927 3035 16598 C04596 Dichlorodiphenyldichloroethylene Sharma HR, Kaushik A, Kaushik CP: Pesticide residues in bovine milk from a predominantly agricultural state of Haryana, India. Environ Monit Assess. 2007 Jun;129(1-3):349-57. doi: 10.1007/s10661-006-9368-5. Epub 2006 Dec 16. 17180431