| Identification |
|---|
| BMDB Protein ID
| BMDBP00010 |
| Secondary Accession Numbers
| |
| Name
| Cytochrome P450 11B1, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| CYP11B1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Secondary metabolites biosynthesis, transport and catabolism |
| Specific Function
| A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11-deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin). |
| Pathways
|
Not Available
|
| Reactions
|
| Deoxycorticosterone + Oxygen + Reduced adrenal ferredoxin → Corticosterone + Water + Oxidized adrenal ferredoxin |
details
|
| Progesterone + Oxygen + Reduced adrenal ferredoxin → 11b-Hydroxyprogesterone + Water + Oxidized adrenal ferredoxin |
details
|
| 17-Hydroxyprogesterone + Oxygen + Reduced adrenal ferredoxin → 21-Deoxycortisol + Water + Oxidized adrenal ferredoxin |
details
|
| Cortexolone + Oxygen + Reduced adrenal ferredoxin → Cortisol + Water + Oxidized adrenal ferredoxin |
details
|
| 17a,21-Dihydroxypreg-nenolone + Oxygen + Reduced adrenal ferredoxin → 11b,17a,21-Trihydroxypreg-nenolone + Water + Oxidized adrenal ferredoxin |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 14 |
| Locus
| Not Available |
| SNPs
| CYP11B1 |
| Gene Sequence
|
>1512 bp
ATGGCACTGTGGGCAAAGGCCAGGGTGCGGATGGCAGGGCCCTGGCTGTCCCTGCATGAG
GCACGCCTACTGGGCACCAGAGGTGCTGTAGCCCCCAAGGCGGTGCTGCCCTTCGAAGCC
ATGCCCCGGTGTCCTGGCAACAAGTGGATGCGGATGCTGCAGATCTGGAAGGAGCAGGGT
TCTGAGAACATGCACTTGGACATGCATCAGACCTTCCAGGAGCTGGGGCCCATTTTCAGG
TACGACGTGGGAGGGAGACACATGGTGTTCGTGATGCTGCCCGAGGACGTGGAGAGGCTG
CAGCAGGCGGACAGCCGTCACCCTCAGCGGATGATCCTGGAGCCCTGGCTGGCCTACCGA
CAGGCTCGCGGGCACAAGTGTGGCGTGTTCTTGCTCAATGGGCCCCAGTGGCGTTTGGAC
CGACTGCGGCTGAACCCAGACGTCCTCTCGCTGCCAGCCCTGCAGAAGTACACGCCCTTG
GTGGATGGCGTGGCCAGGGACTTCTCCCAGACCCTGAAGGCGAGGGTGCTGCAGAATGCT
CGGGGGAGTCTGACCCTGGACATCGCGCCCAGCGTCTTCCGCTACACCATCGAAGCCAGC
ACCTTAGTCCTTTACGGGGAGCGGCTTGGCCTTTTGACCCAGCAACCAAACCCTGACAGC
CTGAACTTTATCCACGCGCTGGAGGCCATGTTGAAGTCCACCGTGCAGCTCATGTTTGTG
CCCAGGCGCCTGTCACGGTGGATGAGCACCAACATGTGGAGGGAGCACTTTGAGGCCTGG
GACTACATCTTCCAGTATGCCAACAGAGCCATCCAGAGAATCTATCAGGAGCTGGCCCTC
GGCCACCCGTGGCACTACAGCGGCATCGTGGCAGAGCTGCTGATGCGAGCAGACATGACC
CTGGATACCATCAAGGCCAACACGATCGACCTCACTGCTGGGAGTGTGGACACGACAGCC
TTCCCCTTGCTGATGACTCTCTTTGAGCTGGCTCGGAACCCGGAGGTGCAGCAGGCGGTG
CGCCAGGAGAGCCTGGTGGCTGAGGCCCGGATCTCAGAAAATCCCCAGAGGGCCATCACG
GAGCTGCCTTTGCTGCGGGCGGCCCTCAAGGAGACCTTGAGGCTGTACCCCGTGGGTATC
ACCTTGGAGCGGGAAGTGAGCTCGGACCTGGTGCTGCAGAACTACCACATCCCAGCTGGG
ACGCTGGTGAAGGTCCTACTCTATTCCCTGGGTCGAAACCCCGCCGTGTTCGCCAGGCCT
GAGAGCTATCACCCCCAGCGCTGGCTGGACCGCCAGGGCTCTGGAAGCAGATTCCCGCAC
CTGGCCTTTGGCTTTGGCGTACGCCAGTGCCTGGGGCGGCGCGTGGCCGAGGTGGAGATG
CTGCTCCTGCTGCACCATGTGCTGAAGAACTTCCTGGTGGAGACACTGGAGCAAGAGGAC
ATAAAGATGGTCTACCGCTTCATACTGATGCCCTCCACCCTGCCCCTCTTCACCTTCCGG
GCCATCCAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 503 |
| Molecular Weight
| 57847.0 |
| Theoretical pI
| 9.73 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Cytochrome P450 11B1, mitochondrial
MALWAKARVRMAGPWLSLHEARLLGTRGAAAPKAVLPFEAMPRCPGNKWMRMLQIWKEQS
SENMHLDMHQTFQELGPIFRYDVGGRHMVFVMLPEDVERLQQADSHHPQRMILEPWLAYR
QARGHKCGVFLLNGPQWRLDRLRLNPDVLSLPALQKYTPLVDGVARDFSQTLKARVLQNA
RGSLTLDIAPSVFRYTIEASTLVLYGERLGLLTQQPNPDSLNFIHALEAMLKSTVQLMFV
PRRLSRWMSTNMWREHFEAWDYIFQYANRAIQRIYQELALGHPWHYSGIVAELLMRADMT
LDTIKANTIDLTAGSVDTTAFPLLMTLFELARNPEVQQAVRQESLVAEARISENPQRAIT
ELPLLRAALKETLRLYPVGITLEREVSSDLVLQNYHIPAGTLVKVLLYSLGRNPAVFARP
ESYHPQRWLDRQGSGSRFPHLAFGFGVRQCLGRRVAEVEMLLLLHHVLKNFLVETLEQED
IKMVYRFILMPSTLPLFTFRAIQ
|
| External Links |
|---|
| GenBank ID Protein
| BAA00127.1 |
| UniProtKB/Swiss-Prot ID
| P15150 |
| UniProtKB/Swiss-Prot Entry Name
| C11B1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| D00185 |
| GeneCard ID
| CYP11B1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
