| Identification |
|---|
| BMDB Protein ID
| BMDBP00012 |
| Secondary Accession Numbers
| None |
| Name
| Tryptophan 2,3-dioxygenase |
| Synonyms
|
Not Available
|
| Gene Name
| TDO2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. |
| Pathways
|
- Amino-acid degradation
- L-kynurenine from L-tryptophan: step 1/2
- L-tryptophan degradation via kynurenine pathway
- Tryptophan Metabolism
|
| Reactions
|
| L-Tryptophan + Oxygen → N'-Formylkynurenine |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| Not Available |
| SNPs
| TDO2 |
| Gene Sequence
|
>1221 bp
ATGAGTGGGTGCCCCTTTTTAGGAAAGAGCTTTGGATATGCTTTTAAACCACTCTCTGCA
CAAGGCAGTGAAGAAGACAAATCACAGGCCGGTGTGAACAGAGCCAGTAAAGGAGGACTT
ATCTATGGGAACTACCTGCAATTGGAAAAAGTTTTGAATGCACAGGAGCTTCAAAGTGAA
ATGAAAGGAAATAAAATCCACGATGAACATCTTTTTATCATAACTCATCAAGCTTATGAA
CTCTGGTTTAAGCAGATCCTGTGGGAATTAGATTCTGTTCGTGAGATCTTTCAGAATGGC
CATGTGAGGGATGAGAGGAACATGCTGAAGGTGATCACCCGAATGCACCGAGTGGTGGTG
ATCCTCAAACTCTTGGTCCAGCAGTTTTCCGTCCTGGAGACCATGACAGCCTTGGACTTC
AATGACTTCAGAGAGTACTTATCCCCGGCGTCCGGCTTCCAGAGTCTGCAGTTCCGCCTG
TTAGAAAACAAGATAGGGGTTCTGCAGAGCTTGAGGGTCCCTTACAACAGAAGACACTAC
CGCGACAACTTCAGAGGGAAAGACAACGAGCTTCTGCTGAAGTCCGAGCAAGAAAGGACG
CTTCTGCAGCTGGTTGAGGCATGGCTGGAAAGAACCCCAGGTTTAGAGCCGCATGGATTT
AACTTCTGGGGAAAGCTTGAAAAGAACATTGTCAAAGGTTTGGAAGAAGAATTCACAAAG
ATTCAGGCTAAGGAAGAGTCAGAGGAAAAGGAGGAACAAATGGCTGAATTTCAGAAGCAG
AAAGAGGTATTACTGTCCTTATTTGATGAGAAACGTCATGAGCATCTCCTTAGTAAAGGA
GAAAGACGGCTATCGTACAAAGCACTTCAGGGGGCCTTGATGATATATTTTTACAGGGAA
GAGCCCAGGTTCCAGGTCCCTTTCCAGCTGCTGACTTTCCTCATGGATGTGGACTCACTC
ATGACCAAGTGGAGATATAACCACGTGTGCCTGGTGCACAGGATGCTCGGCAGCAAGGCG
GGCACTGGCGGGTCCTCTGGGTACCAGTACCTGCGCTCCACCGTGAGTGACAGGTACAAA
GTATTTGTAGATTTATTTAATCTCTCAACATATCTGGTTCCCCGACACTGGATTCCGAAG
ATGAACCCAGTCATTCATAAGTTCCTTTACACGGCTGAATACTGTGACAGCTCTTACTTC
AGCAGTGATGAATCAGATTAA
|
| Protein Properties |
|---|
| Number of Residues
| 406 |
| Molecular Weight
| 47708.0 |
| Theoretical pI
| 7.76 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Tryptophan 2,3-dioxygenase
MSGCPFLGKSFGYAFKPLSAQGSEEDKSQAGVNRASKGGLIYGNYLQLEKVLNAQELQSE
MKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVITRMHRVVV
ILKLLVQQFSVLETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQSLRVPYNRRHY
RDNFRGKDNELLLKSEQERTLLQLVEAWLERTPGLEPHGFNFWGKLEKNIVKGLEEEFTK
IQAKEESEEKEEQMAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYKALQGALMIYFYRE
EPRFQVPFQLLTFLMDVDSLMTKWRYNHVCLVHRMLGSKAGTGGSSGYQYLRSTVSDRYK
VFVDLFNLSTYLVPRHWIPKMNPVIHKFLYTAEYCDSSYFSSDESD
|
| External Links |
|---|
| GenBank ID Protein
| AAI12551.1 |
| UniProtKB/Swiss-Prot ID
| Q2KIQ5 |
| UniProtKB/Swiss-Prot Entry Name
| T23O_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC112550 |
| GeneCard ID
| TDO2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
