| Identification |
|---|
| BMDB Protein ID
| BMDBP00042 |
| Secondary Accession Numbers
| None |
| Name
| Cytochrome P450 2U1 |
| Synonyms
|
Not Available
|
| Gene Name
| CYP2U1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Secondary metabolites biosynthesis, transport and catabolism |
| Specific Function
| A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes. May downregulate the biological activities of N-arachidonoyl-serotonin, an endocannabinoid that has anti-nociceptive effects through inhibition of fatty acid amide hydrolase FAAH, TRPV1 receptor and T-type calcium channels. Catalyzes C-2 oxidation of the indole ring of N-arachidonoyl-serotonin forming a less active product 2-oxo-N-arachidonoyl-serotonin. |
| Pathways
|
- Arachidonic Acid Metabolism
- Caffeine Metabolism
- Estrone Metabolism
- Tryptophan Metabolism
|
| Reactions
|
| Melatonin + Oxygen + Reduced flavoprotein → 6-Hydroxymelatonin + Water + Oxidized flavoprotein |
details
|
| Arachidonic acid + Oxygen → 19(S)-HETE + Water |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| Not Available |
| SNPs
| CYP2U1 |
| Gene Sequence
|
>1632 bp
ATGGCCTCCCCCGGGCTTCCCCAGCCCCCCACCGAGGACGCGGCCTGGCCTCTGCGCCTC
CTGCACGCGCCCCCGGGGCTGCTGCGGCTGGACCCCACGGGCGGCGCGCTGCTGCTGCTC
GTCCTCGCCGCGCTGCTGGGCTGGAGCTGGCTGTGGCGGCTCCCGGAGCGGGGCATCCCC
CCCGGGCCCGCGCCCTGGCCCGTGGTGGGCAACTTCGGCTTCGTGCTGCTGCCGCGTTTT
CTCCGAAGGAAGAGCTGGCCGTATCGCCGAGCGAGAAACGGAGGAATGAATGCCTCGGGC
CAGGGCGTGCAGTTGCTCCTGGCCGACCTGGGCCGTGTGTACGGCAACATCTTTAGCTTC
CTCATCGGCCACTACCTGGTGGTGGTCCTCAACGACTTCCACAGCGTGCGGGAGGCGCTG
GTGCAGCAGGCCGAGGTCTTCAGCGACCGCCCGCGGGTGCCGCTGACCTCCATCATGACC
AAGGGAAAGGGGATTGTATTTGCACATTATGGTCCAGTCTGGAGACAACAGAGGAAGTTC
TCTCATTCAACTCTTCGTCATTTTGGCTTGGGAAAGCTTAGCTTGGAGCCCAAGATTATT
GAGGAGTTCAGATATGTGAAAGAGGAAATGCAAAAGCACGGAGACGCCCCTTTCAATCCT
TTCCCCATTGTCAACAACGCCGTCTCTAACATCATCTGCTCCTTGTGCTTTGGTCGGCGC
TTTGATTACACTAATAGTGAATTTAAGCAAATGCTTAATTTTATGTCACGAGCATTAGAA
GTTTGTCTGAACACCCAGCTCCTCCTGGTCAACATATGCTCCTGGCTTTATTACCTTCCT
TTTGGACCATTTAAGGAATTAAGACAGATTGAAAAGGATTTAACCCTTTTCCTTAAAAAA
ATCATCAAAGATCATCGAGAGTCTTTGGATGTAGAGAACCCTCAGGACTTCATAGACATG
TATCTTCTCCATGTGGAGGAGGAGAAGAAAAATAACAGCAATAGTGGGTTTGATGAAGAT
TACTTATTTTACATCATCGGCGATCTCTTCATTGCTGGCACTGATACCACAACTAACTCT
TTGCTTTGGTGCCTCCTGTATATGTCACTGCACCCCAACATTCAAGAAAAGATTCATGAA
GAAATTGCAAGGGTCATTGGTGCTGACCGCGCCCCCTCCCTCACTGACAAGGCGCAGATG
CCCTACACAGAAGCCACCATCATGGAGGTGCAGAGGCTGAGCACTGTGGTGCCGCTATCC
ATCCCTCACATGACCTCAGAGAAAACAGTGCTCCAAGGTTTTACCATTCCTAAAGGCACA
ATAATATTACCCAACCTATGGTCAGTACACAGAGACCCAGCCATCTGGGAGAAACCAAAT
GATTTCTACCCTGATCGATTTCTGGATGATCAAGGACAACTTATTAAAAAGGAAACGTTT
ATTCCTTTTGGGATAGGGAAGCGGGTGTGTATGGGAGAGCAGCTGGCAAAGATGGAGTTG
TTCCTGATGTTCGTGAGCCTAATGCAGAGTTTCACGTTTGTTTTACCTAAGGATTCAAAG
CCAATCCTGACTGGGAAATATGGTCTAACTTTAGCCCCACATCCATTTAATATAATCATT
TCAAAGAGATAA
|
| Protein Properties |
|---|
| Number of Residues
| 543 |
| Molecular Weight
| 61997.0 |
| Theoretical pI
| 8.87 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 32-52
- 58-78
- 261-281
- 342-362
- 495-515
|
| Protein Sequence
|
>Cytochrome P450 2U1
MASPGLPQPPTEDAAWPLRLLHAPPGLLRLDPTGGALLLLVLAALLGWSWLWRLPERGIP
PGPAPWPVVGNFGFVLLPRFLRRKSWPYRRARNGGMNASGQGVQLLLADLGRVYGNIFSF
LIGHYLVVVLNDFHSVREALVQQAEVFSDRPRVPLTSIMTKGKGIVFAHYGPVWRQQRKF
SHSTLRHFGLGKLSLEPKIIEEFRYVKEEMQKHGDAPFNPFPIVNNAVSNIICSLCFGRR
FDYTNSEFKQMLNFMSRALEVCLNTQLLLVNICSWLYYLPFGPFKELRQIEKDLTLFLKK
IIKDHRESLDVENPQDFIDMYLLHVEEEKKNNSNSGFDEDYLFYIIGDLFIAGTDTTTNS
LLWCLLYMSLHPNIQEKIHEEIARVIGADRAPSLTDKAQMPYTEATIMEVQRLSTVVPLS
IPHMTSEKTVLQGFTIPKGTIILPNLWSVHRDPAIWEKPNDFYPDRFLDDQGQLIKKETF
IPFGIGKRVCMGEQLAKMELFLMFVSLMQSFTFVLPKDSKPILTGKYGLTLAPHPFNIII
SKR
|
| External Links |
|---|
| GenBank ID Protein
| AAI22664.1 |
| UniProtKB/Swiss-Prot ID
| Q0IIF9 |
| UniProtKB/Swiss-Prot Entry Name
| CP2U1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC122663 |
| GeneCard ID
| CYP2U1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
