| Identification |
|---|
| BMDB Protein ID
| BMDBP00060 |
| Secondary Accession Numbers
| None |
| Name
| Steroid 21-hydroxylase |
| Synonyms
|
Not Available
|
| Gene Name
| CYP21 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Secondary metabolites biosynthesis, transport and catabolism |
| Specific Function
| Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids. |
| Pathways
|
|
| Reactions
|
| 11b-Hydroxyprogesterone + Oxygen + Reduced acceptor → Corticosterone + Water + Acceptor |
details
|
| 21-Deoxycortisol + Oxygen + Reduced acceptor → Cortisol + Water + Acceptor |
details
|
| Progesterone + Oxygen + Reduced acceptor → Deoxycorticosterone + Water + Acceptor |
details
|
| 17-Hydroxyprogesterone + Oxygen + Reduced acceptor → Cortexolone + Water + Acceptor |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 23 |
| Locus
| Not Available |
| SNPs
| CYP21 |
| Gene Sequence
|
>1491 bp
CCTCTGCCTGGGTCTCCAGCCATGGTCCTCGCAGGGCTGCTGCTGCTGCTGACCCTGCTC
AGTGGCGCTCACCTGCTATGGGGCCGGTGGAAGCTCAGAAACCTCCACCTCCCACCTCTG
GTCCCCGGCTTCCTGCACCTGCTGCAGCCCAACCTCCCCATCCATCTGCTGAGCCTGACT
CAGAAACTCGGGCCTGTCTACAGGCTTCGCCTTGGGCTGCAAGAGGTGGTGGTGCTGAAC
TCCAAGAGGACCATTGAGGAGGCTATGATCAGGAAGTGGGTGGACTTTGCCGGCAGACCC
CAGATACCATCCTACAAGTTGGTGTCTCAGCGCTGCCAGGACATCTCTCTGGGGGACTAC
TCTCTGCTCTGGAAGGCCCACAAGAAACTCACCCGCTCAGCCTTGCTGCTGGGCACCCGC
AGCTCCATGGAGCCCTGGGTGGACCAGCTGACCCAGGAGTTCTGCGAGCGCATGAGAGTC
CAGGCCGGTGCCCCCGTGACCATCCAGAAGGAATTCTCTCTGCTTACCTGCAGCATCATC
TGTTACCTCACTTTTGGAAACAAGGAGGACACCTTAGTACATGCCTTTCACGACTGTGTT
CAGGACTTGATGAAGACCTGGGACCACTGGTCCATCCAGATTTTGGACATGGTTCCTTTT
CTCAGGTTCTTCCCCAACCCTGGGCTCTGGAGGCTGAAGCAGGCCATAGAGAACAGGGAC
CACATGGTGGAGAAGCAGCTGACGCGCCACAAGGAGAGCATGGTGGCCGGCCAGTGGAGG
GATATGACGGACTACATGCTCCAGGGGGTAGGGAGGCAAAGAGTAGAAGAGGGCCCCGGA
CAGCTCCTGGAAGGACACGTGCACATGTCTGTGGTGGACCTTTTCATCGGGGGCACTGAA
ACCACGGCGAGCACCCTCTCCTGGGCTGTGGCGTTCCTACTTCACCACCCCGAGATTCAG
CGCCGCCTTCAGGAGGAGTTGGATCGCGAGCTGGGCCCCGGAGCCTCATGCTCCCGAGTC
ACTTACAAGGACCGCGCTCGGCTGCCTCTGCTCAACGCCACCATCGCGGAGGTGCTGCGC
CTGCGGCCGGTCGTGCCCCTGGCCTTGCCTCACCGCACCACGCGGCCTAGCAGCATCTTC
GGCTACGACATCCCTGAGGGCATGGTCGTTATCCCCAACCTCCAAGGTGCCCACCTGGAC
GAGACCGTCTGGGAGCAGCCGTACGAGTTCCGGCCGGACCGCTTCCTGGAGCCGGGCGCG
AACCCCAGCGCGCTGGCATTTGGCTGCGGGGCGCGCGTGTGCCTGGGCGAGTCGCTGGCG
CGCCTGGAGCTGTTCGTGGTGCTCCTGCGACTGCTGCAGGCCTTCACGCTGCTGCCGCCG
CCCGTGGGCGCCCTGCCGTCGCTGCAGCCGGATCCCTACTGCGGTGTCAACCTCAAGGTC
CAGCCTTTCCAGGTGCGGCTGCAGCCCCGGGGGGTGGAGGCCGGGGCCTGG
|
| Protein Properties |
|---|
| Number of Residues
| 496 |
| Molecular Weight
| 56077.0 |
| Theoretical pI
| 8.34 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Steroid 21-hydroxylase
MVLAGLLLLLTLLAGAHLLWGRWKLRNLHLPPLVPGFLHLLQPNLPIHLLSLTQKLGPVY
RLRLGLQEVVVLNSKRTIEEAMIRKWVDFAGRPQIPSYKLVSQRCQDISLGDYSLLWKAH
KKLTRSALLLGTRSSMEPWVDQLTQEFCERMRVQAGAPVTIQKEFSLLTCSIICYLTFGN
KEDTLVHAFHDCVQDLMKTWDHWSIQILDMVPFLRFFPNPGLWRLKQAIENRDHMVEKQL
TRHKESMVAGQWRDMTDYMLQGVGRQRVEEGPGQLLEGHVHMSVVDLFIGGTETTASTLS
WAVAFLLHHPEIQRRLQEELDRELGPGASCSRVTYKDRARLPLLNATIAEVLRLRPVVPL
ALPHRTTRPSSIFGYDIPEGMVVIPNLQGAHLDETVWEQPHEFRPDRFLEPGANPSALAF
GCGARVCLGESLARLELFVVLLRLLQAFTLLPPPVGALPSLQPDPYCGVNLKVQPFQVRL
QPRGVEAGAWESASAQ
|
| External Links |
|---|
| GenBank ID Protein
| AAA83247.1 |
| UniProtKB/Swiss-Prot ID
| P00191 |
| UniProtKB/Swiss-Prot Entry Name
| CP21A_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| M11267 |
| GeneCard ID
| CYP21 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
