| Identification |
|---|
| BMDB Protein ID
| BMDBP00067 |
| Secondary Accession Numbers
| None |
| Name
| Ferrochelatase, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| FECH |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Coenzyme transport and metabolism |
| Specific Function
| Catalyzes the ferrous insertion into protoporphyrin IX. |
| Pathways
|
- Porphyrin Metabolism
- Porphyrin-containing compound metabolism
- Protoheme biosynthesis
- Protoheme from protoporphyrin-IX: step 1/1
|
| Reactions
|
| Protoporphyrin IX + Iron → Heme +2 Hydrogen |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 24 |
| Locus
| Not Available |
| SNPs
| FECH |
| Gene Sequence
|
>1251 bp
ATGGCTGCGGCCTTGCGATCTGCGGGCGTCCTGCTCCGCGATCGGCTGCTGTACGGCGGC
TCAAGGGCCTGTCAGCCACGGAGGTGCCAGTCAGGTGCGGCCACAGCGGCGGCCGCCACG
GAAACCGCCCAGCGTGCCAGAAGCCCCAAGCCTCAGGCTCAGCCGGGGAACAGGAAGCCA
AGGACTGGAATATTGATGCTGAACATGGGGGGCCCGGAAACCGTCGAAGAAGTCCAGGAC
TTCCTTCAGAGGCTCTTTCTGGACCAAGACCTCATGACGCTCCCCGTCCAAGATAAGCTG
GGACCATTCATCGCCAAACGCCGAACCCCCAAAATTCAGGAGCAGTACCGCAGGATTGGA
GGCGGATCGCCCATCAAGATGTGGACCTCCAAGCAGGGGGAAGGCATGGTGAAGCTGCTG
GATGAGCTGTCCCCACACACAGCCCCGCACAAATACTATATTGGATTCCGGTACGTCCAC
CCGTTAACAGAGGAAGCAATTGAAGAGATGGAGAGGGACGGCCTGGAGAGGGCGGTTGCT
TTCACGCAGTACCCCCAGTACAGCTGCTCCACCACAGGCAGCAGCTTAAATGCCATTTAC
AGATACTACAATGAAGTGGGCAGGAAGCCCACCATGAAGTGGAGCACGATCGACAGGTGG
CCCACGCACCCCCTCCTCATCCAGTGCTTTGCTGACCATATTCTGAAAGAGCTGGATCAC
TTTCCTCCTGAGAAGAGACGCGAGGTGGTCATTCTTTTTTCTGCTCACTCACTGCCAATG
TCTGTGGTCAACAGAGGGGACCCCTATCCTCAAGAGGTAGGCGCCACTGTCCAGAGAGTC
ATGGACAAGCTGGGTTACTCCAACCCCTACCGACTTGTTTGGCAGTCCAAGGTTGGCCCG
ATGCCCTGGCTGGGTCCTCAGACAGACGAGGCCATCAAAGGGCTTTGTAAGAGGGGAAGG
AAGAACATCCTTTTAGTGCCAATAGCGTTTACCAGCGATCACATCGAAACGCTCTATGAG
CTGGACATCGAGTACTCTCAAGTTCTAGCCAGTGAGTGTGGACTTGAAAACATCAGAAGA
GCGGAGTCTCTTAATGGAAACCCACTGTTCTCGAAGGCCCTGGCCGACCTGGTGCACTCA
CACCTCCAGTCCAAGGAGCGCTGCTCCACACAGCTGACTCTGAGCTGTCCGCTCTGCGTG
AACCCTACCTGCAGGGAGACCAAATCCTTCTTCACCAGCCAGCAGCTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 416 |
| Molecular Weight
| 46935.0 |
| Theoretical pI
| 9.04 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Ferrochelatase, mitochondrial
MAAALRSAGVLLRDRLLYGGSRACQPRRCQSGAATAAAATETAQRARSPKPQAQPGNRKP
RTGILMLNMGGPETVEEVQDFLQRLFLDQDLMTLPVQDKLGPFIAKRRTPKIQEQYRRIG
GGSPIKMWTSKQGEGMVKLLDELSPHTAPHKYYIGFRYVHPLTEEAIEEMERDGLERAVA
FTQYPQYSCSTTGSSLNAIYRYYNEVGRKPTMKWSTIDRWPTHPLLIQCFADHILKELDH
FPPEKRREVVILFSAHSLPMSVVNRGDPYPQEVGATVQRVMDKLGYSNPYRLVWQSKVGP
MPWLGPQTDEAIKGLCKRGRKNILLVPIAFTSDHIETLYELDIEYSQVLASECGLENIRR
AESLNGNPLFSKALADLVHSHLQSKERCSTQLTLSCPLCVNPTCRETKSFFTSQQL
|
| External Links |
|---|
| GenBank ID Protein
| AAA79169.1 |
| UniProtKB/Swiss-Prot ID
| P22600 |
| UniProtKB/Swiss-Prot Entry Name
| HEMH_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| L34173 |
| GeneCard ID
| FECH |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
