| Identification |
|---|
| BMDB Protein ID
| BMDBP00070 |
| Secondary Accession Numbers
| |
| Name
| Heme oxygenase 1 |
| Synonyms
|
Not Available
|
| Gene Name
| HMOX1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in heme oxygenase (decyclizing) activity |
| Specific Function
| Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| Not Available |
| SNPs
| HMOX1 |
| Gene Sequence
|
>870 bp
ATGGAGCGCCCGCAGCCCGACAGCAGCATGCCCCAGGATTTGTCAGAGGCCCTGAAGGAG
GCCACCAAGGAGGTGCACACCCAGGCGGAGAATGCAGAGTTCATGAAGAACTTTCAGAAG
GGTGAGCTGACCCAAGAAGGTTTTAAGCTGGTGATGGCGTCTTTGTACCACATCTATGTG
GCCCTGGAGGAGGAGATCGAACGCAACAAGGAGAACCCCGTCTACACTCCCCTCTACTTC
CCAGAGGAGCTGCACCGCCGGGCCTCCCTGGAGCAGGACATGGCCTTCTGGTACGGGCCC
CGCTGGCAGGAGGCCATCCCCTACACGCAGGCCACCAAGCGCTATGTTCAGCGACTCCAG
GAGGTGGGGCGCACCGAGCCCGAACTGCTGGTGGCCCATGCCTACACCCGCTACCTGGGA
GACCTGTCTGGGGGCCAAGTTCTCAAGAAGATTGCTCAGAAGGCCCTGAATCTGCCCAGC
TCCGGGGAGGGCCTGGCCTTCTTCACTTTCCCCAATATCGCCAGTGCCACCAAGTTCAAG
CAGCTGTACCGCTCCCGCATGAACACTCTGGAGATGACCCCTGAGGTCCGGCAGAGGGTC
CTGGATGAGGCCAAGACCGCCTTCCTGCTCAACATCCAGCTGTTTGAGGAGTTGCAGGGC
CTGCTGACCCAGAAGGCCAAGGACCATGATCCCTTGCAGGCACCAGAGCTTCACAGGCGA
GCCGGCAGCAAGGTGCAAGACTTGGCTCCCACCAAGGCGTCCAGGGGGAAGCCCCAGCCC
AGCGTCCTCTCCCAGGCACCTCTCCTGCGATGGGTCCTCACACTCAGCTTTCTGGTGGCC
ACGGTCGCTGTGGGGCTTTACGCCATGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 289 |
| Molecular Weight
| 32940.0 |
| Theoretical pI
| 7.88 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Heme oxygenase 1
MERPQPDSSMPQDLSEALKEATKEVHTQAENAEFMKNFQKGELTQEGFKLVMASLYHIYV
ALEEEIERNKENPVYTPLYFPEELHRRASLEQDMAFWYGPRWQEAIPYTQATKRYVQRLQ
EVGRTEPELLVAHAYTRYLGDLSGGQVLKKIAQKALNLPSSGEGLAFFTFPNIASATKFK
QLYRSRMNTLEMTPEVRQRVLDEAKTAFLLNIQLFEELQGLLTQKAKDHDPLQAPELHRR
AGSKVQDLAPTKASRGKPQPSVLSQAPLLRWVLTLSFLVATVAVGLYAM
|
| External Links |
|---|
| GenBank ID Protein
| AAX08985.1 |
| UniProtKB/Swiss-Prot ID
| Q5E9F2 |
| UniProtKB/Swiss-Prot Entry Name
| HMOX1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT020968 |
| GeneCard ID
| HMOX1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
