| Identification |
|---|
| BMDB Protein ID
| BMDBP00072 |
| Secondary Accession Numbers
| None |
| Name
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 |
| Synonyms
|
Not Available
|
| Gene Name
| PLCB1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Cell cycle control, cell division, chromosome partitioning |
| Specific Function
| The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. |
| Pathways
|
- Activation of PKC Through G Protein-Coupled Receptor
- Cadmium Induces DNA Synthesis and Proliferation in Macrophages
- G-Protein Signaling Through Tubby Proteins
- GnRH Signaling Pathway
- Histamine H1 Receptor Activation
- Muscle/Heart Contraction
- Phosphatidylinositol Phosphate Metabolism
- Phospholipase C Signaling Pathway
- Phospholipase C Signaling Pathway
- Succinate Signalling During Inflammation
|
| Reactions
|
| PIP2 + Water → DG + IP3 |
details
|
| phosphatidylinositol 4,5-bisphosphate + Water → 1,2-Diacyl-sn-glycerol + Inositol 1,4,5-trisphosphate |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 13 |
| Locus
| Not Available |
| SNPs
| PLCB1 |
| Gene Sequence
|
>3651 bp
ATGGCCGGGGCACAGCCTGGAGTGCACGCGCTGCAACTCAAGCCGGTGTGCGTGTCCGAC
AGCCTCAAGAAGGGCACCAAATTCGTCAAGTGGGAGGATGACTCCACTGTTGTCACTCCG
ATTATTTTGAGGACTGACCCTCAGGGATTTTTCTTTTACTGGACAGATCAAAACAAGGAG
ACGGAGCTGTTAGATCTCAGCCTTGTCAAAGACGCCAGATGTGGGAAACATGCCAAGGCG
CCCAAGGACCCTAAATTACGTGAACTTCTGGATGTGGGGAACATTGGGCGCCTGGAACAT
CGCATGATCACAGTGGTGTATGGGCCTGACTTAGTGAACATCTCCCATTTGAACCTCGTG
GCTTTCCAAGAAGAAGTGGCCAAGGAATGGACAAATGAGGTTTTCAGTTTGGCAACAAAC
CTGCTGGCCCAAAACATGTCCAGGGATGCATTTCTGGAAAAGGCGTATACTAAGCTTAAG
CTGCAAGTCACTCCAGAAGGACGCATTCCTCTCAAAAACATATACCGCCTGTTCTCAGCA
GACCGGAAGCGAGTCGAGACAGCTTTAGAGGCTTGTAGTCTTCCATCTTCAAGGAATGAT
TCGATACCTCAAGAAGATTTCACTCCTGAAGTGTACAGAGTTTTCCTGAACAACCTTTGT
CCTCGACCTGAAATTGATAACATCTTTTCCGAATTTGGTGCCAAAAGCAAACCATACCTT
ACAGTTGATCAGATGATGGATTTTATCAACCTCAAGCAGCGAGATCCCCGGCTAAATGAA
ATACTTTACCCACCTTTAAAGCAAGAGCAAGTCCAAGTGTTGATTGAGAAGTATGAACCT
AACAACAGCCTCGCCAAAAAAGGACAGATATCAGTGGATGGATTTATGCGCTATCTGAGT
GGAGAAGAAAATGGAGTCGTTTCACCTGAGAAACTGGATTTGAATGAAGATATGTCTCAG
CCCCTTTCTCACTATTTCATTAATTCCTCACACAACACCTACCTCACAGCTGGCCAGCTG
GCTGGAAACTCCTCCGTTGAGATGTATCGCCAAGTGCTCCTGTCTGGTTGTCGCTGTGTG
GAGCTGGACTGCTGGAAGGGACGAACTGCAGAAGAGGAGCCAGTCATCACCCATGGGTTC
ACCATGACCACAGAAATATCCTTCAAGGAAGTGATTGAAGCCATTGCTGAATGTGCATTT
AAGACTTCACCTTTTCCAATTCTGCTTTCATTTGAGAACCATGTGGACTCGCCGAAGCAG
CAAGCCAAGATGGCGGAGTACTGCAGACTCATCTTCGGCGACGCCCTCCTCATGGAGCCG
CTGGACAAGTACCCGTTGGAATCTGGAGTTCCCCTTCCAAGTCCTATGGATTTAATGTAC
AAAATTTTGGTGAAAAATAAGAAGAAATCACACAAGTCGTCAGAAGGAAGTGGCAAGAAG
AAGCTCTCAGAACAAGCTTCCAACACGTACAGCGACTCCTCCAGTGTGTTTGAGCCCTCG
TCCCCAGGAGCCGGAGAAGCTGATACAGAGAGTGACGATGATGACGATGATGATGACTGT
AAAAAGTCTTCAATGGATGAGGGGACCGCAGGGAGCGAGGCCATGGCCACAGAAGAGATG
TCTAATCTGGTGAACTATATCCAGCCAGTCAAGTTCGAGTCATTTGAAATTTCAAAAAAA
AGAAATAGAAGCTTCGAGATGTCTTCCTTTGTGGAAACCAAAGGTCTTGAGCAACTTACA
AAGTCTCCGGTGGAATTTGTAGAATATAACAAAATGCAGCTTAGCAGGATATATCCAAAG
GGAACACGCGTGGATTCATCTAACTATATGCCTCAGCTCTTCTGGAATGCAGGCTGCCAA
ATGGTTGCTCTTAATTTCCAAACAGTGGACCTGGCTATGCAGATAAACATGGGGATGTAT
GAATATAATGGGAAGAGTGGCTACAGGCTGAAGCCGGAGTTCATGAGGAGACCTGACAAG
CACTTTGATCCATTCACAGAAGGCATCGTGGACGGCATAGTGGCCAACACTTTATCTGTT
AAGATTATTTCAGGTCAGTTTCTCTCTGATAAGAAAGTCGGGACTTATGTGGAAGTGGAT
ATGTTTGGTTTGCCTGTGGACACAAGGAGGAAGGCATTTAAGACCAAAACATCACAAGGA
AACGCTGTAAATCCCATCTGGGAAGAAGAACCCATTGTATTCAAAAAGGTGGTCCTTCCT
TCGCTAGCCTGTTTGAGGATAGCAGTTTATGAAGAAGGAGGTAAATTTATTGGTCACCGA
ATCTTGCCAGTACAAGCAATTCGGCCAGGCTATCACTACATCTGTCTGAGGAATGAGAGG
AACCAGCCTCTCATGCTGCCAGCGCTCTTTGTCTACATAGAGGTGAAGGACTATGTCCCA
GACACATATGCAGATGTGATTGAAGCTTTGTCAAATCCAATCCGATATGTGAATCTGATG
GAGCAGAGAGCTAAACAACTGGCTGCTTTGACACTGGAAGATGAAGAAGAAGTGAAGAAA
GAGGCTGATCCTGGGGAAACACCATCAGAAGCTCCGAGTGAAGCCAGGCCAACTCCAGCA
GAAAACGGGGTGAATCACACAACGTCCCTGACACCCAAACCACCCTCCCAGGCTCTGCAC
AGCCAGCCAGCTCCAGGTTCTGTAAAGGCACCTGCCAAAACAGAAGATCTTATTCAGAGT
GTTTTAACAGAAGTAGAAGCGCAGACGATTGAAGAGCTAAAGCAGCAGAAGTCGTTTGTG
AAACTTCAAAAGAAGCACTACAAGGAAATGAAGGACCTGGTTAAGAGACACCACAAGAAA
ACCACCGACCTCATCAAAGAGCACACTACAAAATACAATGAAATCCAGAATGACTACTTG
AGAAGGAGAGCAGCTCTGGAAAAGACAGCCAAAAAGGACAATAAGAAAAAATCAGAACCC
AGTAGCCCTGACCACGTCTCATCAACAATTGAGCAAGACCTTGCTGCCCTGGATGCCGAG
ATGACCCAAAAGTTAGTAGATCTGAAGGACAAACAGCAGCAGCAGCTGCTTAATCTTCGA
CAAGAGCAATACTATAGCGAAAAATACCAGAAACGAGAACACATTAAACTGCTTATTCAA
AAATTGACTGATGTTGCTGAAGAATGTCAGAATAATCAGTTAAAGAAGCTCAAAGAAATC
TGTGAGAAAGAGAAGAAGGAATTAAAGAAGAAAATGGATAAAAAGAGGCAGGAGAAGATA
ACAGAAGCAAAATCCAAAGACAAAAGCCAGATGGAGGAGGAAAAGACAGAGATGATCCGG
TCATACATCCAGGAGGTGGTGCAGTACATCAAGAGGTTAGAAGAGGCGCAAAGTAAACGG
CAAGAAAAACTCGTAGAGAAACACAAAGAAATCCGCCAGCAGATCCTGGATGAAAAGCCC
AAGCTACAGGTGGAACTGGAGCAGGAATACCAAGACAAGTTCAAAAGGCTGCCCCTGGAG
ATTTTGGAATTTGTGCAGGAAGCCATGAAAGGGAAGATTAGTGAAGACAGCAATCACAGC
TCTGCCCCTCCCCTGATGACCTCAGACTCTGGAAAACTAAACCAGAAGCCTCCTTCCAGT
GAAGAATTGGAAGGAGAAAACCCAGGAAAAGAGTTTGATACCCCTCTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1216 |
| Molecular Weight
| 138715.0 |
| Theoretical pI
| 6.05 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWEDDSTVVTPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGRLEHRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLAKKGQISVDGFMRYLS
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLDKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK
KLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFEISKKRNRSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
NAVNPIWEEEPIVFKKVVLPSLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER
NQPLMLPALFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
EADPGETPSEAPSEARPTPAENGVNHTTSLTPKPPSQALHSQPAPGSVKAPAKTEDLIQS
VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL
RRRAALEKTAKKDNKKKSEPSSPDHVSSTIEQDLAALDAEMTQKLVDLKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP
KLQVELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHSSAPPLMTSDSGKLNQKPPSS
EELEGENPGKEFDTPL
|
| External Links |
|---|
| GenBank ID Protein
| AAA30702.1 |
| UniProtKB/Swiss-Prot ID
| P10894 |
| UniProtKB/Swiss-Prot Entry Name
| PLCB1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| J03137 |
| GeneCard ID
| PLCB1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
