| Identification |
|---|
| BMDB Protein ID
| BMDBP00073 |
| Secondary Accession Numbers
| None |
| Name
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 |
| Synonyms
|
Not Available
|
| Gene Name
| PLCD4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 2 |
| Locus
| Not Available |
| SNPs
| PLCD4 |
| Gene Sequence
|
>2376 bp
ATGGCGTATCTGCTGCAAGGCCGGCTGCCCATCAATCAAGATCTGCTGCTGATGCAGAAA
GGCACAATGATGCGCAAGGTGAGGTCCAAAAGCTGGAAGAAGCTAAGATTCTTCAGACTT
CAGGACGATGGCATGACAGTCTGGCATGCCCGGCAGGCTGGAGGCAGGGCCAAGCCCAGC
TTCTCAATCTCCGACGTGGACACAGTACGTGAGGACCACGAGTCTGAGTTGCTGCGCAAC
CTGGCAGAGGAGTTCCCCCTGGAGCAGGGCTTCACCATCGTCTTCCATGGCCGCCGCTCC
AACCTGGACCTGGTGGCCAACAGTGTCCAGGAAGCCCAGACCTGGATGCAGGGGCTCCAG
CTGTTGGTGGGCTTTGTCACCAACATGGACCAACAGGAGAGGCTGGATCAATGGCTGAGT
GATTGGTTCCAGCGCGGAGACAAAAACCAGGATGGTCGGATGAGTTTCGGAGAGGTCCAA
CGGTTATTGCACCTGATGAATGTGGAAATGGACCAGGAATATGCCTTTCAGCTTTTCCAG
ACAGCAGACACATCCCAGTCTGGGACTCTGGAGGGAGAAGAATTTGTAGAGTTCTATAAG
TCATTGACTCAGCGTCCAGAAGTGCAGGAACTGTTTGAAAAGTTTTCATCTGATGGGCAG
AAACTGACCCTGTTGGAATTTGTGGATTTCCTCCAAGAGGAACAGAAGGAAGGAGAACGG
GCTTCTGACCTTGCTCTGGAACTCATCGACCGCTATGAGCCTTCAGAAAGTGGAAAACTG
CGGCATGTGCTGAGCATGGATGGCTTCCTCGGCTACCTCTGCTCGAAGGACGGAGACATC
TTCAATCCAACCTGCCACCCCCTCTACCAGGACATGACTCAACCCCTGAACCACTACTAC
ATCAACTCCTCCCACAACACCTACCTGGTGGGGGACCAGCTTTGTGGCCAGAGCAGCGTG
GAGGGATACATACGGGCCCTGAAGCGGGGGTGCCGCTGTGTGGAGGTGGATATATGGGAT
GGACCAAGCGGGGAACCTATTGTTTACCACGGACACACCCTGACCTCCCGCATCCCATTC
AAAGATGTTGTGGCCGCTATAGGACAGTATGCCTTCCAGACGTCAGACTATCCAGTCATC
TTGTCGCTGGAGAACCACTGCAGCTGGGAGCAGCAGGAGATCATCGTGCGCCATCTGACG
GAGATCCTGGGGGATCAGCTACTGACGACAGCCTTGGATGGGCAGCCTCCCACTCAGCTG
CCCTCCCCCGAGGACCTTCGGGGGAAGATCCTTGTGAAGGGGAAGAAGCTAATGCTTGAG
GAAGAGGAGGAAGAACCAGAGGCTGAATTGGAAGCAGAGCAGGAGGCTAGGCTGGACTTG
GAGGCCCAGCTGGAGTCTGAGCCCCAGGACCTGAGCCCTCGCAGTGAGGACAAAAAGAAG
GTTGTGATGTGCCCGCTGTTGTGTCGGCCTTTGTGTTGTCAGATTATGGCCCAGGCTCCT
ATTTCCAAGCCTGGGCTTCTTCTCTTTCCCAAGCAGAAACCCAAGGCCATCTTGTGTCCA
GCCCTCTCTGCCCTGGTTGTCTACTTGAAGGCTGTCACATTCTATAGCTTCACTCACTCG
AGGGAGCACTACCACTTCTATGAAACATCATCTTTCTCTGAAACCAAGGCCAAGAGCCTC
ATCAAGGAGGCTGGTGACGAGTTTGTGCAGCACAATGCCTGGCAGTTAAGCAGAGTGTAT
CCCAGTGGCCTGAGGACGGATTCATCCAACTACAACCCCCAGGAATTCTGGAATGCAGGC
TGCCAGATGGTGGCTATGAACATGCAGACAGCCGGGCTGGAGATGGACCTGTGTGATGGG
CTCTTCCGCCAGAACGCTGGCTGTGGCTATGTGCTGAAGCCAGACTTCCTGCGCGATGCC
CAGAGTTCCTTCCACCCTGAGAGGCCCATCAGCCCTTTCAAAGCCCAGACCCTCATCATC
CAGGTAATCAGTGGTCAGCAACTCCCCAAAGTGGACAACACCAAAGAACAGTCCATTGTG
GACCCCTTGGTGAGAGTGGAGATCTTTGGCGTCCGCCCAGACACAACCCGGCAAGAGACC
AGCTACGTGGAGAACAATGGTTTTAATCCATACTGGGGGCAGACACTGTGCTTCCGGATC
CTGGTACCTGAACTGGCCCTGCTGCGTTTTGTGGTCAAAGACTATGACTGGAAATCCCGA
AACGACTTCATTGGTCAGTACACCCTGCCGTGGAGCTGCATGCAGCAAGGTTACCGCCAC
ATACACCTGCTCTCCAAGGATGGCCTCAGCCTTCACCCAGCTTCCATCTTTGTGCACATC
TGCACACAGGAAGTGTCAGAGGAGGCTGAATCTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 791 |
| Molecular Weight
| 90581.0 |
| Theoretical pI
| 4.89 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-4
MAYLLQGRLPINQDLLLMQKGTMMRKVRSKSWKKLRFFRLQDDGMTVWHARQAGGRAKPS
FSISDVDTVREDHESELLRNLAEEFPLEQGFTIVFHGRRSNLDLVANSVQEAQTWMQGLQ
LLVGFVTNMDQQERLDQWLSDWFQRGDKNQDGRMSFGEVQRLLHLMNVEMDQEYAFQLFQ
TADTSQSGTLEGEEFVEFYKSLTQRPEVQELFEKFSSDGQKLTLLEFVDFLQEEQKEGER
ASDLALELIDRYEPSESGKLRHVLSMDGFLGYLCSKDGDIFNPTCHPLYQDMTQPLNHYY
INSSHNTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDIWDGPSGEPIVYHGHTLTSRIPF
KDVVAAIGQYAFQTSDYPVILSLENHCSWEQQEIIVRHLTEILGDQLLTTALDGQPPTQL
PSPEDLRGKILVKGKKLMLEEEEEEPEAELEAEQEARLDLEAQLESEPQDLSPRSEDKKK
VVMCPLLCRPLCCQIMAQAPISKPGLLLFPKQKPKAILCPALSALVVYLKAVTFYSFTHS
REHYHFYETSSFSETKAKSLIKEAGDEFVQHNAWQLSRVYPSGLRTDSSNYNPQEFWNAG
CQMVAMNMQTAGLEMDLCDGLFRQNAGCGYVLKPDFLRDAQSSFHPERPISPFKAQTLII
QVISGQQLPKVDNTKEQSIVDPLVRVEIFGVRPDTTRQETSYVENNGFNPYWGQTLCFRI
LVPELALLRFVVKDYDWKSRNDFIGQYTLPWSCMQQGYRHIHLLSKDGLSLHPASIFVHI
CTQEVSEEAES
|
| External Links |
|---|
| GenBank ID Protein
| AAI12450.1 |
| UniProtKB/Swiss-Prot ID
| P21671 |
| UniProtKB/Swiss-Prot Entry Name
| PLCD4_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC112449 |
| GeneCard ID
| PLCD4 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
