| Identification |
|---|
| BMDB Protein ID
| BMDBP00075 |
| Secondary Accession Numbers
| |
| Name
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 |
| Synonyms
|
Not Available
|
| Gene Name
| PLCD1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 22 |
| Locus
| Not Available |
| SNPs
| PLCD1 |
| Gene Sequence
|
>2271 bp
ATGGACTCGGGCCGGGACTTCCTGACCCTGCACGGCCTACAGGATGACAAGGACCTACAG
GCACTGCTGAAGGGCGGCCAACTCTTGAAGGTGAAGTCCAACTCATGGCGGAGAGAACGC
TTCTACAAGCTGCAGGAGGACTGCAAGACCATCTGGCAGGAGTCCCGCAAGGTCATGAGG
ACCCCGGAATCCCAGCTGTTCTCCATCGAGGACATCCAGGAGGTGCGGATGGGGCACCGC
ACAGAGGGCCTGGAGAAGTTTGCTCGGGATGTGCCTGAGAATCGCTGCTTCTCCATAGTC
TTCAAGGACCAGCGCAATACTCTAGACCTCATTGCCCCATCACCAGCCGATGCCCAGCAC
TGGGTGCAGGGCCTGGGCAAGATCATCCACCACTCGGGCTCCATGGACCAGCAGCAGAAG
CTGCGACACTGGATTCATTCCTGCTTGCGAAAAGCTGACAAAAACAAGGACAACAAGATG
AGCTTCAAAGAGCTACAAAACTTTCTGAAGGAGCTCAACATCCAGGTGGACGACAGCTAT
GCCCGAAAGATCTTCAAGGAATGTGACCACTCTCAGACAGACTCCCTGGAGGATGAGGAG
ATAGAGACCTTCTACAAGATACTGACCCAGAGGAAGGAGATCGACCGCACCTTCGAGGAG
GCCACGGGCTCCAAGGAGACCCTGTCGGTGGATCAGTTGGTGACCTTCTTGCAGCACCAG
CAGCGGGAGGAGGAGGCGGGGCCTGCACTGGCTCTCTCCCTCATTGAGCGCTACGAACCC
AGTGAGACGGCCAAGGCGCAGCGTCAGATGACCAAGGACGGCTTTCTTATGTACCTGCTC
TCGGCTGACGGCAGCGCCTTCGACCTGGCGCACCGGCGCGTCTACCAGGACATGGACCAG
CCGCTCAGCCACTACCTGGTGTCGTCCTCGCACAACACCTACCTGCTGGAAGACCAGCTC
ACGGGTCCCAGCAGCACAGAAGCCTACATCCGGGCGCTGTGCAAAGGCTGCCGCTGCCTG
GAGCTCGACTGCTGGGATGGGCCCAACCAGGAGCCGATCATCTATCATGGCTACACCTTC
ACCTCCAAGATCCTCTTCTGCGACGTGGTCAGGGCCATCCGGGACTACGCCTTCAAGGCA
TCCCCCTACCCCGTCATCCTGTCCTTGGAGAACCACTGCAGCCTGGAACAGCAGCGTGTG
ATGGCGCGACACCTGCGCACCCTCCTGGGGCCCATGCTGTTGGATCGGCCATTGGACGGG
GTCGTCACCAGCCTGCCTTCCCCTGAGCAACTGAGGGGGAAGATCTTGCTGAAGGGGAAG
AAGCTTGGGGGGCTCTTCCCGCCTGGAGGAGAAGGTGGCCCAGAGGCCACTGTGGTGTCA
GACGAGGATGAGGCTGCTGAGATGGAGGACGAGGCGGTGAGGAGCCAAGTGCAGCACAAG
TCCAAGGAGGACAAGCTCAGGCTAGCGAAGGAACTCTCCGACATGGTCATTTACTGCAAG
AGTGTCCACTTTCGGGGCTTCCCCAGCTCTGGCACCTCTGGACAGGCTTTCTATGAGATG
TCATCCTTCTCTGAGAACCGCGCCCTCCGACTGCTCCAAGAATCAGGAAACAGCTTTGTC
CGCCACAACGTGAATCACCTGAGCAGGATCTACCCCGCTGGGTGGAGAACGGACTCTTCC
AACTACAGCCCCGTGGAGATGTGGAATGGGGGCTGCCAGATCGTGGCCCTGAACTTCCAG
ACTCCTGGGTCAGAGATGGATGTGTACCAGGGCCGCTTCCTGGACAATGGGGCCTGTGGG
TACGTGCTGAAGCCTGCCTTCCTGCGAGACCCCAACTCTACCTTCAACTCCCGTGCCCTG
GCCCACGGGCCCTGGTGGACTCCGAAACGACTCAATGTCAGGGTCATCTCAGGGCAGCAG
CTGCCAAAAGTCAACAAGAATAAGAATTCAATCGTGGACCCCAAGGTGACAGTGGAGATC
CATGGCGTGAGCCGGGACGTGGCCAGCCGCCAGACCGCTGTGGTCACCAATAACGGTTTC
AATCCGTGGTGGGACACAGAGTTGGAGTTTGAGGTGGCTGTGCCTGAGCTTGCCCTTGTG
CGCTTTGTGGTGGAGGACTACGATGCCTCCTCCAAGAACGACTTCATTGGCCAGAGCACC
ATCCCCTTGAAAAGCCTCAAGCAGGGATACCGACACATCCACCTCCTCTCCAAGAACGGG
GACCAGCACCCGTCTGCCACCCTCTTTGTGAAGGTGGCCCTCCAGGACTAG
|
| Protein Properties |
|---|
| Number of Residues
| 756 |
| Molecular Weight
| 86073.0 |
| Theoretical pI
| 6.72 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1
MDSGRDFLTLHGLQDDKDLQALLKGGQLLKVKSNSWRRERFYKLQEDCKTIWQESRKVMR
TPESQLFSIEDIQEVRMGHRTEGLEKFARDVPENRCFSIVFKDQRNTLDLIAPSPADAQH
WVQGLGKIIHHSGSMDQQQKLRHWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSY
ARKIFKECDHSQTDSLEDEEIETFYKILTQRKEIDRTFEEATGSKETLSVDQLVTFLQHQ
QREEEAGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFDLAHRRVYQDMDQ
PLSHYLVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTF
TSKILFCDVVRAIRDYAFKASPYPVILSLENHCSLEQQRVMARHLRTLLGPMLLDRPLDG
VVTSLPSPEQLRGKILLKGKKLGGLFPPGGEGGPEATVVSDEDEAAEMEDEAVRSQVQHK
SKEDKLRLAKELSDMVIYCKSVHFRGFPSSGTSGQAFYEMSSFSENRALRLLQESGNSFV
RHNVNHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGSEMDVYQGRFLDNGACG
YVLKPAFLRDPNSTFNSRALAHGPWWTPKRLNVRVISGQQLPKVNKNKNSIVDPKVTVEI
HGVSRDVASRQTAVVTNNGFNPWWDTELEFEVAVPELALVRFVVEDYDASSKNDFIGQST
IPLKSLKQGYRHIHLLSKNGDQHPSATLFVKVALQD
|
| External Links |
|---|
| GenBank ID Protein
| AAI33305.1 |
| UniProtKB/Swiss-Prot ID
| P10895 |
| UniProtKB/Swiss-Prot Entry Name
| PLCD1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC133304 |
| GeneCard ID
| PLCD1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
