| Identification |
|---|
| BMDB Protein ID
| BMDBP00076 |
| Secondary Accession Numbers
| None |
| Name
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 |
| Synonyms
|
Not Available
|
| Gene Name
| PLCG1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (By similarity). |
| Pathways
|
- BCR Signaling Pathway
- CXCR4 Signaling Pathway
- EGF Signalling Pathway
- EPO Signaling Pathway
- Fc Epsilon Receptor I Signaling in Mast Cells
- Growth Hormone Signaling Pathway
- Ion Channel and Phorbal Esters Signaling Pathway
- Phospholipase C Signaling Pathway
- Phospholipase C Signaling Pathway
- T Cell Receptor Signaling Pathway
|
| Reactions
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 13 |
| Locus
| Not Available |
| SNPs
| PLCG1 |
| Gene Sequence
|
>3876 bp
ATGGCGGGCGCCGCGTCCCCCTGCGCCAACGGCTGCGGGCCCAGTGCGCCCTCGGACGCC
GAGGTGGTGCACCTCTGCCGCAGCCTCGAGGTGGGCACCGTCATGACTTTGTTCTACTCC
AAGAAGTCGCAGCGGCCCGAGCGGAAGACCTTCCAGGTCAAGCTGGAGACGCGGCAGATC
ACGTGGAGCCGAGGCGCCGACAAGATAGAGGGGGCCATTGACATTCGTGAAATCAAGGAG
ATCCGCCCAGGGAAGACCTCACGGGACTTCGATCGCTACCAAGAGGATCCTGCTTTTCGA
CCGGACCAGTCCCACTGCTTCGTCATCCTGTATGGAATGGAATTCCGCCTGAAGACCCTG
AGCCTCCAAGCCACGTCTGAGGACGAAGTGAACATGTGGATCAGGGGCCTGACTTGGCTG
ATGGAGGACACGTTGCAGGCAGCCACACCCCTGCAGATTGAGAGGTGGCTGCGGAAGCAG
TTCTACTCAGTGGACCGGAACCGTGAGGACCGGATATCGGCCAAGGACCTGAAGAACATG
CTGTCCCAGGTCAACTACCGGGTCCCCAACATGCGCTTCCTCCGGGAGCGGCTGACGGAC
CTGGAGCAGCGCACCAGTGACATCACCTACGGGCAGTTTGCACAGCTGTACCGCAGCCTC
ATGTACAGCGCCCAGAAGACGATGGACCTTCCTTTCCTGGAAGCCAGCGCCCTGAGGGCG
GGGGAGCGGCCGGAGCTGTGCCGGGTGTCCCTTCCTGAGTTCCAGCAGTTCCTCCTCGAG
TACCAAGGGGAGCTGTGGGCGGTGGACCGGCTCCAGGTGCAGGAGTTCATGCTCAGCTTC
CTCCGAGACCCCTTGCGAGAGATTGAGGAGCCTTACTTCTTCCTGGACGAGTTCGTCACC
TTCCTGTTCTCCAAGGAGAACAGCATATGGAACTCGCAGCTAGACGAGGTGTGCCCCGAC
ACCATGAACAACCCCCTGTCCCACTACTGGATCTCCTCCTCGCACAACACGTACCTGACC
GGGGACCAGTTCTCCAGCGAGTCCTCCCTGGAAGCCTACGCTCGCTGCCTGCGGATGGGC
TGCCGTTGCATTGAGTTGGACTGCTGGGACGGCCCGGATGGGATGCCGGTCATTTACCAT
GGACACACTCTGACCACCAAGATCAAGTTCTCAGACGTCCTGCACACCATCAAGGAGCAC
GCCTTTGTGGCCTCAGAGTACCCGGTCATCCTGTCCATCGAGGACCACTGCAGCATTGCC
CAGCAGAGGAACATGGCCCAGTATTTCAAAAAGGTGCTTGGGGACACACTCCTCACCAAG
CCCGTGGATATTGCAGCCGACGGGCTCCCCTCCCCCAACCAGCTCAAGAGGAAGATCCTT
ATCAAGCACAAGAAGTTGGCTGAGGGCAGTGCCTACGAGGAGGTGCCAACATCGGTGATG
TACTCTGAGAACGACATCAGCAACTCCATCAAGAATGGCATCCTCTACCTGGAAGACCCT
GTGAACCATGAGTGGTACCCCCACTACTTCGTCCTGACCAGCAGCAAGATCTACTACTCG
GAGGAGACCAGCAGCGACCAGGGCAACGAGGATGAGGAGGAGCCCAAGGAGGCCAGTGGC
AGCACAGAGCTGCACTCCAACGAGAAGTGGTTCCACGGGAAGCTTGGGGCGGGCCGGGAT
GGGCGGCACATCGCCGAGCGCCTGCTCACGGAGTACTGCATTGAGACCGGGGCCCCCGAC
GGCTCCTTCCTTGTGCGCGAGAGCGAGACCTTTGTGGGCGACTACACTCTGTCCTTCTGG
CGGAATGGCAAAGTGCAGCACTGCCGGATCCACTCCCGGCAGGACGCAGGCACCCCCAAG
TTCTTCCTGACGGACAACCTCGTCTTCGACTCCCTCTATGACCTCATCACGCACTACCAG
CAGGTGCCCCTGCGCTGCAACGAATTTGAGATGCGCCTCTCAGAGCCGGTCCCGCAGACC
AACGCGCACGAGAGCAAAGAGTGGTACCACGCCAGCCTGACCAGAGCGCAGGCCGAGCAC
ATGCTGATGCGTGTACCCAGGGACGGGGCCTTCCTGGTGCGGAAACGGAACGAGCCCAAC
TCCTACGCCATCTCCTTCCGGGCTGAGGGCAAGATCAAGCACTGCCGCGTCCAGCAGGAG
GGCCAGACCGTGATGCTGGGCAACTCAGAGTTTGACAGCCTTGTCGACCTCATCAGCTAC
TACGAGAAGCACCCACTGTACCGCAAGATGAAGCTGCGCTACCCCATCAACGAGGAGGCT
CTGGAGAAGATCGGCACAGCTGAGCCTGACTACGGCGCGCTGTACGAGGGCCGCAACCCT
GGCTTCTATGTGGAGGCGAACCCCATGCCCACGTTCAAGTGCGCCGTCAAAGCTCTCTTC
GACTACAAAGCGCAGCGGGAGGACGAGCTGACATTCACCAAGAGTGCCATCATCCAGAAC
GTGGAGAAGCAGGAGGGAGGCTGGTGGCGGGGTGACTACGGCGGGAAGAAGCAGCTGTGG
TTCCCTTCAAACTATGTGGAGGAAATGGTCAGCCCGGCGGCCCTGGAGCCCGAGAGGGAG
CACTTGGACGAGAACAGCCCACTCGGGGACTTGCTCCGGGGGGTCCTGGATGTGCCAGCT
TGTCAGATAGCCGTCCGTCCCGAGGGCAAGAACAACCGGCTGTTCGTCTTCTCCATCAGC
ATGGCCTCGGTGGCACACTGGTCCCTGGATGTGGCTGCCGACTCGCAGGAAGAGCTGCAG
GACTGGGTGAAGAAGATCCGGGAGGTGGCGCAGACAGCGGATGCCAGGCTCACCGAGGGC
AAGATGATGGAGCGGAGGAAGAAGATCGCCCTAGAGCTCTCAGAGCTCGTCGTCTACTGC
CGGCCTGTCCCTTTCGACGAAGAGAAGATTGGCACCGAACGGGCCTGCTACCGCGACATG
TCGTCCTTCCCGGAGACCAAGGCCGAGAAGTACGTGAACAAGGCCAAAGGCAAGAAGTTC
CTCCAGTACAACCGCCTGCAGCTCTCCCGCATCTACCCTAAGGGCCAGCGGCTGGACTCC
TCCAATTACGACCCCCTGCCCATGTGGATCTGCGGCAGCCAGCTTGTGGCCCTCAACTTC
CAGACCCCAGACAAACCCATGCAGATGAACCAGGCCCTGTTCCTGGCCGGCGGGCACTGT
GGCTATGTGCTGCAGCCCAGCGTCATGCGCGATGAGGCCTTCGATCCCTTTGACAAGAGC
AGCCTCCGCGGGCTGGAGCCGTGCGCCATCTGCATCGAGGTGCTGGGGGCCCGGCACCTG
CCGAAGAACGGCCGAGGCATCGTGTGTCCTTTTGTGGAGATCGAGGTGGCCGGAGCCGAG
TATGACAGCATCAAGCAGAAGACAGAGTTTGTGGTGGACAATGGACTGAACCCCGTGTGG
CCAGCCAAGCCCTTCCACTTCCAGATTAGTAACCCCGAGTTCGCCTTCCTGCGCTTCGTG
GTCTATGAGGAGGACATGTTTAGTGACCAGAACTTCCTAGCTCAGGCTACCTTCCCAGTG
AAGGGTCTGAAGACAGGCTACAGAGCGGTGCCTCTGAAGAACAACTACAGTGAGGGCCTG
GAGCTGGCCTCCCTGCTCGTCAAGATTGACGTGTTCCCTGCCAAGCAGGAGAACGGCGAC
CTCAGCCCCTTCGGGGGTGCGTCCCTGCGGGAGCGGAGCTGTGACGCCTCGGGCCCGCTG
TTCCACGGCCGGGCCCGGGAGGGCTCCTTTGAAGCTCGCTACCAGCAGCCCTTTGAGGAC
TTCCGCATCTCCCAGGAGCATCTCGCAGACCATTTTGACGGTCGGGATCGCAGGACCCCA
CGCAGGACTCGGGTCAACGGAGACAACCGCCTGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 1291 |
| Molecular Weight
| 148313.0 |
| Theoretical pI
| 5.85 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
MAGAASPCANGCGPSAPSDAEVVHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQI
TWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTL
SLQATSEDEVNMWIRGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNREDRISAKDLKNM
LSQVNYRVPNMRFLRERLTDLEQRTSDITYGQFAQLYRSLMYSAQKTMDLPFLEASALRA
GERPELCRVSLPEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYFFLDEFVT
FLFSKENSIWNSQLDEVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMG
CRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIA
QQRNMAQYFKKVLGDTLLTKPVDIAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVM
YSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYSEETSSDQGNEDEEEPKEASG
STELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFW
RNGKVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQT
NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQE
GQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALEKIGTAEPDYGALYEGRNP
GFYVEANPMPTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQEGGWWRGDYGGKKQLW
FPSNYVEEMVSPAALEPEREHLDENSPLGDLLRGVLDVPACQIAVRPEGKNNRLFVFSIS
MASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKMMERRKKIALELSELVVYC
RPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDS
SNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFLAGGHCGYVLQPSVMRDEAFDPFDKS
SLRGLEPCAICIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSIKQKTEFVVDNGLNPVW
PAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEGL
ELASLLVKIDVFPAKQENGDLSPFGGASLRERSCDASGPLFHGRAREGSFEARYQQPFED
FRISQEHLADHFDGRDRRTPRRTRVNGDNRL
|
| External Links |
|---|
| GenBank ID Protein
| CAA68406.1 |
| UniProtKB/Swiss-Prot ID
| P08487 |
| UniProtKB/Swiss-Prot Entry Name
| PLCG1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| Y00301 |
| GeneCard ID
| PLCG1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
