| Identification |
|---|
| BMDB Protein ID
| BMDBP00085 |
| Secondary Accession Numbers
| None |
| Name
| Serine palmitoyltransferase 1 |
| Synonyms
|
Not Available
|
| Gene Name
| SPTLC1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Coenzyme transport and metabolism |
| Specific Function
| Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference (By similarity). Required for adipocyte cell viability and metabolic homeostasis (By similarity). |
| Pathways
|
- Lipid metabolism
- Sphingolipid Metabolism
|
| Reactions
|
| Palmityl-CoA + L-Serine → 3-Dehydrosphinganine + Carbon dioxide |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| Not Available |
| SNPs
| SPTLC1 |
| Gene Sequence
|
>1422 bp
ATGGCGACCGTCGCGGAGCAGTGGGTCCTGGTGGAGATGGTCCAGGCGCTCTACGAGGCT
CCTGCTTATCATCTTATTTTAGAAGGAATTTTAATACTCTGGATAATCAGACTTCTTTTC
TCTAAAACTTACAAATTACAAGAACGATCTGATCTTACACTCAAGGAAAAGGAAGAATTG
ATTGAAGAGTGGCAACCAGAGCCTCTTGTTCCTCCTGTCTCAAAAGACCATCCTGCTCTC
AACTACAACATTGTTTCAGGCCCTCCAAGCCATAACATCGTGGTGAATGGAAAAGAATGT
ATAAACTTTGCTTCATTCAATTTTCTTGGATTGTTGGATAACCCTAGGCTCAAGGCAGCA
GCTTTGGCATCTCTAAAGAAGTATGGTGTGGGAACTTGTGGACCTAGAGGATTTTATGGC
ACATTTGATGTGCACTTGGATTTAGAAGACCGCCTGGCAAAATTTATGAAGACAGAAGAA
GCCATAATATACTCATATGGATTTGCCACCATAGCCAGTGCTATTCCTGCTTACTCTAAG
AGAGGGGACATTGTGTTTGTAGATAAAGCTGCCTGCTTTGCTATTCAGAAGGGATTACAG
GCATCACGTAGTGACATTAAGGTGTTTAACCATAATGATATGGACGACCTGGAGCGACTA
CTAAAAGAACAAGAGATTGAAGATCAAAAGAATCCTCGCAAGGCTCGTGTAACTCGACGT
TTCATTATAGTTGAAGGATTGTATATGAATACTGGAACTGTTTGCCCTCTTCCAGAATTG
GTTAAGTTAAAATATAAATATAAAGCAAGAATCTTTCTGGAGGAAAGCCTTTCATTTGGA
GTCCTGGGAGAGCATGGCCGAGGAGTCACGGAACATTTTGGAATCAGTATTGATGATATT
GATCTTATCAGTGCCAACATGGAGAACTCACTGGCATCTATTGGGGGTTTCTGCTGTGGC
AGGTCTTTCGTAATTGACCATCAGCGACTTTCTGGCCAGGGATACTGCTTTTCAGCTTCG
TTACCTCCCCTGTTAGCTGCTGCTGCGATTGAGGCTCTCAACATCATGGAAGAGAATCCA
GGTATTTTTGCAGTGTTGAAGGAAAAATGCAAACGAATTCATAAAGCTTTACAAGGCATT
CCTGGACTAAAAGTAGTGGGGGAGTCTATTTCTCCAGCATTGCACCTCCAACTGGAAGAG
ACCACTGGGTGTCGAGAAAGAGATGTTAAACTGCTTCAGGAAATAGTAACTCAATGCATG
GACAGAGGCATCGCATTGACTCAGGCACGCTACTTGGAGAAAGAAGAAAAGTACCTCCCC
CCTCCGAGCATTAGGGTTGTGGTCACAGTGGAACAAACAGAAGAGGACCTGGAGAAAGCT
GCGTCCACGATCAGCGAGGTGGCCCAGACCGTGCTGCTTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 473 |
| Molecular Weight
| 52788.0 |
| Theoretical pI
| 5.7 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Serine palmitoyltransferase 1
MATVAEQWVLVEMVQALYEAPAYHLILEGILILWIIRLLFSKTYKLQERSDLTLKEKEEL
IEEWQPEPLVPPVSKDHPALNYNIVSGPPSHNIVVNGKECINFASFNFLGLLDNPRLKAA
ALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAIIYSYGFATIASAIPAYSK
RGDIVFVDKAACFAIQKGLQASRSDIKVFNHNDMDDLERLLKEQEIEDQKNPRKARVTRR
FIIVEGLYMNTGTVCPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHFGISIDDI
DLISANMENSLASIGGFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENP
GIFAVLKEKCKRIHKALQGIPGLKVVGESISPALHLQLEETTGCRERDVKLLQEIVTQCM
DRGIALTQARYLEKEEKYLPPPSIRVVVTVEQTEEDLEKAASTISEVAQTVLL
|
| External Links |
|---|
| GenBank ID Protein
| AAI05251.1 |
| UniProtKB/Swiss-Prot ID
| Q3MHG1 |
| UniProtKB/Swiss-Prot Entry Name
| SPTC1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC105250 |
| GeneCard ID
| SPTLC1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
