| Identification |
|---|
| BMDB Protein ID
| BMDBP00093 |
| Secondary Accession Numbers
| |
| Name
| Dihydroorotate dehydrogenase (quinone), mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| DHODH |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Nucleotide transport and metabolism |
| Specific Function
| Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. |
| Pathways
|
- Orotate from (S)-dihydroorotate (quinone route): step 1/1
- Pyrimidine Metabolism
- UMP biosynthesis via de novo pathway
|
| Reactions
|
| L-Dihydroorotic acid + Quinone → Orotic acid + quinol |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 18 |
| Locus
| Not Available |
| SNPs
| DHODH |
| Gene Sequence
|
>1188 bp
ATGGCGTGGAGGCAGCTCAAAAAGCGGGCCCAGGATGCCATGGTGATCCTGGGGGGCGGA
GGACTTCTCTTTGCCTCCTACTTGACGGCCACGGGGGATGAGCACTTCTACGCTGAACTC
TTGATGCCGTCTCTGCAGCGGCTGCTGGACCCTGAGACAGCCCACAGGCTGGCTGTTCGC
TTCACCTCCCTGGGGCTCCTTCCTCGAACCACGTTTCAAGACTCTGACATGCTGGAAGTG
AGAGTCCTTGGCCATAAATTCCGAAATCCAGTGGGAATCGCCGCAGGATTTGACAAGCAC
GGGGAAGCGGTGGATGGCCTTTACAAGATGGGCTTTGGTTTTGTTGAGATAGGCAGTGTA
ACCCCAGAACCTCAGGAAGGAAACCCCAGGCCCAGGGTCTTCCGCCTCCCAGAAGACCAA
GCTATCATTAACAGATACGGATTTAACAGTCATGGACTCTCAGTGGTGGAACACAGGTTA
CGGGCCAGACAGCAGACACAGGCCAGACTCACAGAAGATGGGCTGCCGCTGGGAATAAAC
CTGGGGAAGAATAAGACCTCGGTGGACGCTGCCTCCGACTATGCAGAGGGGGTTCGAGTC
CTGGGTCCCTTGGCTGACTACCTGGTAGTGAATGTGTCCAGTCCCAACACGGCTGGGCTG
CGGAGCCTTCAGGGAAAGGCCGAACTGCGCCGCCTGCTGACCAAGGTGCTGCAGGAGAGG
GATGCCCTGAAGGTGGCCCACAAGCCAGCTGTCCTGGTGAAGATTGCTCCCGACCTCACA
GCCCAGGACAAGGAGGATATTGCCAGCGTGGTGAGAGAGTTGGGCATCGATGGACTGATC
GTCACAAACAGCACAGTGAGTCGCCCTGCCAGCCTCCAGGGTGCCCTGCGCTCTGAACCA
GGAGGGCTGAGCGGGAAGCCCCTCAGGGATTTATCAACGCAAACCATCCGGGAGATGTAT
GCACTCACCCAAGGCAGAGTTCCCATCGTCGGGGTTGGCGGTGTCAGCAGCGGGCAGGAT
GCGCTGGAGAAGATCCGCGCGGGAGCCTCCCTCGTGCAGCTGTACACGGCCCTCACCTAC
CGGGGCCCGCCCGTAGTGGGCGGGGTCAAGCGGGAGCTGGAAGCCCTTTTGAAGGAGCAG
GGTTTTGCCAGAGTCACAGACGCCATTGGGGCAGATCATCGGAGGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 395 |
| Molecular Weight
| 42776.0 |
| Theoretical pI
| 9.96 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Dihydroorotate dehydrogenase, mitochondrial
MAWRQLKKRAQDAMVILGGGGLLFASYLTATGDEHFYAELLMPSLQRLLDPETAHRLAVR
FTSLGLLPRTTFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPEPQEGNPRPRVFRLPEDQAIINRYGFNSHGLSVVEHRLRARQQTQARLTEDGLPLGIN
LGKNKTSVDAASDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DALKVAHKPAVLVKIAPDLTAQDKEDIASVVRELGIDGLIVTNSTVSRPASLQGALRSEP
GGLSGKPLRDLSTQTIREMYALTQGRVPIVGVGGVSSGQDALEKIRAGASLVQLYTALTY
RGPPVVGGVKRELEALLKEQGFARVTDAIGADHRR
|
| External Links |
|---|
| GenBank ID Protein
| AAX08824.1 |
| UniProtKB/Swiss-Prot ID
| Q5E9W3 |
| UniProtKB/Swiss-Prot Entry Name
| PYRD_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BT020807 |
| GeneCard ID
| DHODH |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
