| Identification |
|---|
| BMDB Protein ID
| BMDBP00100 |
| Secondary Accession Numbers
| None |
| Name
| Phenylethanolamine N-methyltransferase |
| Synonyms
|
Not Available
|
| Gene Name
| PNMT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phenylethanolamine N-methyltransferase acti |
| Specific Function
| Converts noradrenaline to adrenaline. |
| Pathways
|
- (R)-adrenaline biosynthesis
- (R)-adrenaline from (R)-noradrenaline: step 1/1
- Catecholamine biosynthesis
- Nicotinate and Nicotinamide Metabolism
- Tryptophan Metabolism
- Tyrosine Metabolism
|
| Reactions
|
| S-Adenosylmethionine + Norepinephrine → S-Adenosylhomocysteine + Epinephrine |
details
|
| Serotonin + S-Adenosylmethionine → N-Methylserotonin + S-Adenosylhomocysteine |
details
|
| Tryptamine + S-Adenosylmethionine → N-Methyltryptamine + S-Adenosylhomocysteine |
details
|
| S-Adenosylmethionine + Niacinamide → S-Adenosylhomocysteine + 1-Methylnicotinamide |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| Not Available |
| SNPs
| PNMT |
| Gene Sequence
|
>855 bp
GGGCACAGGCGCTGAGCAGCAGCATGAGCGGGACAGACCGGAGTCAGGCGGCGGGCGCAG
TGCCCGACTCAGACCCGGGCCTGGCGGCGGTCTCCTCGGCCTACCAGCGCTTTGAGCCCC
GCGCCTACCTCCGCAACAACTACGCGCCCCCGAGGGGGGACCTGAGCTGCCCCGACGGCG
TCGGGCCTTGGAAGCTGCGCTGCTTGGCTCAGACCTTCGCCACCGGTGAGGTGTCTGGCC
GCACCCTCATTGACATCGGTTCAGGACCCACTATATACCAGCTGCTCAGCGCCTGTGCCC
ACTTTGAGGACATCACCATGACAGATTTCCTGGAGGTGAACCGCCAGGAGCTGAGGCTCT
GGCTGCGAGAAGAGCCTGGGGCTTTCGACTGGAGCGTGTACAGCCAGCATGTCTGCCTCA
TCGAGGGCAAGGGGGAATCCTGGCAGGAGAAGGAGTGCCAGCTGCGAGCCAGGGTGAAGA
GGATCCTGCCCATCGATGTGCACCGGCCCCAGCCCCTGGGTGCTGGAGGCCTGGCACCCC
TGCCTGCCGACGCCCTGGTCTCTGCCTTCTGCCTGGAGGCTGTGAGTCCAGACCTGGCCA
GCTTCCAGCGGGCCCTGGACCACATCACCACACTGCTGAGGCCTGGGGGGCACCTCCTCC
TCATCGGAGCCCTGGAGGAGTCATGGTACCTGGCTGGGGAGGCCAGGCTGGCGGTGGTGC
CCGTGCGCGAGGAGGAGGTGAGGGAGGCCCTGGTGCGGAGCGCTATGAGGTGCGGGATCT
GCGCACTACACCTACACCATGCCTGCCCACCTTCAGACAGGTGTAGACGATGTCAAGGGC
ATCTTCTTCACCTGG
|
| Protein Properties |
|---|
| Number of Residues
| 283 |
| Molecular Weight
| 30918.0 |
| Theoretical pI
| 6.25 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Phenylethanolamine N-methyltransferase
MSGTDRSQAAGAVPDSDPGLAAVSSAYQRFEPRAYLRNNYAPPRGDLSCPDGVGPWKLRC
LAQTFATGEVSGRTLIDIGSGPTIYQLLSACAHFEDITMTDFLEVNRQELRLWLREEPGA
FDWSVYSQHVCLIEGKGESWQEKECQLRARVKRILPIDVHRPQPLGAGGLAPLPADALVS
AFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLAVVPVREEEVR
EALVRTATRCGICARTPMPAHLQTGVDDVKGIFFTRAQKKVGV
|
| External Links |
|---|
| GenBank ID Protein
| AAA30716.1 |
| UniProtKB/Swiss-Prot ID
| P10938 |
| UniProtKB/Swiss-Prot Entry Name
| PNMT_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| M36706 |
| GeneCard ID
| PNMT |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
