| Identification |
|---|
| BMDB Protein ID
| BMDBP00102 |
| Secondary Accession Numbers
| |
| Name
| Prostaglandin-H2 D-isomerase |
| Synonyms
|
Not Available
|
| Gene Name
| PTGDS |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in prostaglandin-D synthase activity |
| Specific Function
| Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system (By similarity). |
| Pathways
|
Not Available
|
| Reactions
|
| Prostaglandin H2 → Prostaglandin D2 |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| Not Available |
| SNPs
| PTGDS |
| Gene Sequence
|
>576 bp
ATGGCCACTCCGAATAGGCTGTGGATGGCGCTGCTCCTGCTGGGGGTCCTGGGGGTCCTG
CAGACCCCAGCCCCCGCCCAGGCCGCCCTGCAGCCCAACTTCGAAGAGGACAAGTTTCTG
GGGCGCTGGTTCACCTCCGGCCTTGCCTCCAACTCGAGCTGGTTCCTGGAGAAGAAGAAG
GTGCTGTCCATGTGCAAGTCTGTGGTGGCCCCCGCGGCGGACGGCGGCCTCAACCTCACC
TCTACCTTCCTCAGGAAAGACCAGTGTGAGACGCGGACCTTACTGCTGCGCCCCGCCGGC
CCCCCAGGCTGCTACAGCTACACCAGCCCTCACTGGAGCAGCACCCACGAGGTGTCAGTG
GCAGAGACAGACTACGAGACCTACGCCCTGCTCTACACAGAGGGTGTCCGAGGCCCGGGG
CAGGACTTCCGCATGGCCACGCTCTACAGCCGCTCCCAGAACCCCCGAGCCGAGGTCAAG
GAACACTTCACCACCTTTGCCAAGAGCCTGGGCTTCACAGAGGAAGGCATTGTGTTCCTG
CCGAAGACTGACAAGTGCATGGAGGAGCACCCATAG
|
| Protein Properties |
|---|
| Number of Residues
| 191 |
| Molecular Weight
| 21229.0 |
| Theoretical pI
| 6.92 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Prostaglandin-H2 D-isomerase
MATPNRLWMALLLLGVLGVLQTPAPAQAALQPNFEEDKFLGRWFTSGLASNSSWFLEKKK
VLSMCKSVVAPAADGGLNLTSTFLRKDQCETRTLLLRPAGPPGCYSYTSPHWSSTHEVSV
AETDYETYALLYTEGVRGPGQDFRMATLYSRSQNPRAEVKEHFTTFAKSLGFTEEGIVFL
PKTDKCMEEHP
|
| External Links |
|---|
| GenBank ID Protein
| BAA20431.1 |
| UniProtKB/Swiss-Prot ID
| O02853 |
| UniProtKB/Swiss-Prot Entry Name
| PTGDS_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB004647 |
| GeneCard ID
| PTGDS |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
