| Identification |
|---|
| BMDB Protein ID
| BMDBP00110 |
| Secondary Accession Numbers
| None |
| Name
| Porphobilinogen deaminase |
| Synonyms
|
Not Available
|
| Gene Name
| HMBS |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Coenzyme transport and metabolism |
| Specific Function
| Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. |
| Pathways
|
- Coproporphyrinogen-III from 5-aminolevulinate: step 2/4
- Porphyrin Metabolism
- Porphyrin-containing compound metabolism
- Protoporphyrin-IX biosynthesis
|
| Reactions
|
| 4 Porphobilinogen + Water → Hydroxymethylbilane +4 Ammonia |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 15 |
| Locus
| Not Available |
| SNPs
| HMBS |
| Gene Sequence
|
>1086 bp
ATGTCTGGTAATGGCAACGCGGCCGCAATAGCGGAAGAAGACACCCCAAAGATGAGAGTG
ATTCGAGTGGGTACCCGCAAGAGCCAGCTGGCTCGCATACAGACGGACAGTGTGGTGGCA
ACGCTGAAAGCTTTATACCCAGGCCTGCAGTTTGAAATAATTGCTATGTCCACCACGGGG
GACAAGATTCTTGATACCGCGCTCTCTAAGATTGGAGAGAAGAGCCTGTTTACCAAGGAG
CTGGAGCATGCTTTGGAGAGGAATGAAGTGGACCTAGTTGTTCATTCGCTGAAGGACCTG
CCCACGGTGCTTCCTCCTGGCTTCACCATTGGAGCTGTCTGCAAGCGGGAGAGCCCCTAT
GATGCTGTTGTCTTTCACCCAAAATTTGTTGGGAAGACTCTAGAAACCTTGCCAGAGAAG
AGTGTGGTAGGAACTAGCTCCCTGCGGAGAGCAGCCCAGCTGCAGAGAAAGTTCCCACAT
CTGGAGTTCAAGAGTATTCGGGGAAACCTCAACACGCGACTGCGGAAGCTGGATGAGCTG
CAGGAGTTCAGTGCCATCATCCTGGCCACAGCTGGCCTGCAGCGCATGGGCTGGCAGAAC
CGGGTGGGGCAGATCCTGCACCCCGAGGAGTGCATGTATGCTGTGGGTCAGGGGGCTCTG
GGTGTGGAAGTTCGAGCCAAAGACCAGGACATCTTGGATCTGGTGGGTGTGTTGCACGAT
CCTGAGACTCTACTTCGCTGCATTGCTGAACGATCCTTCCTAAGGCACCTGGAAGGAGGT
TGCAGTGTGCCAGTGGCAGTGCATACAGCTATTAAGGATGGGCAACTGTACCTGACTGGA
GGAGTCTGGAGTCTGAATGGTGCAGAGACCATGCAAGACACCATGCAAACCACCATCCAT
GTCCCTGTCCAGCATGAAGATGGCCCTGAAGATGATCCACAGCTGGTGGGCATCACTGCC
CGGAACATTCCACGACAACCCCAGCTGGCTGCTGAGAACCTGGGCATCAGCCTGGCCACC
TTGTTGCTGAACAAAGGAGCCAAGAACATCTTGGATGTTGCACGGCAGCTCAATGAAGCC
CACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 361 |
| Molecular Weight
| 39515.0 |
| Theoretical pI
| 6.91 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Porphobilinogen deaminase
MSGNGNAAAIAEEDTPKMRVIRVGTRKSQLARIQTDSVVATLKALYPGLQFEIIAMSTTG
DKILDTALSKIGEKSLFTKELEHALERNEVDLVVHSLKDLPTVLPPGFTIGAVCKRESPY
DAVVFHPKFVGKTLETLPEKSVVGTSSLRRAAQLQRKFPHLEFKSIRGNLNTRLRKLDEL
QEFSAIILATAGLQRMGWQNRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLHD
PETLLRCIAERSFLRHLEGGCSVPVAVHTAIKDGQLYLTGGVWSLNGAETMQDTMQTTIH
VPVQHEDGPEDDPQLVGITARNIPRQPQLAAENLGISLATLLLNKGAKNILDVARQLNEA
H
|
| External Links |
|---|
| GenBank ID Protein
| AAI12574.1 |
| UniProtKB/Swiss-Prot ID
| Q2KIN5 |
| UniProtKB/Swiss-Prot Entry Name
| HEM3_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC112573 |
| GeneCard ID
| HMBS |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
