| Identification |
|---|
| BMDB Protein ID
| BMDBP00112 |
| Secondary Accession Numbers
| None |
| Name
| Delta-aminolevulinic acid dehydratase |
| Synonyms
|
Not Available
|
| Gene Name
| ALAD |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Coenzyme transport and metabolism |
| Specific Function
| Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity). |
| Pathways
|
- Coproporphyrinogen-III from 5-aminolevulinate: step 1/4
- Porphyrin Metabolism
- Porphyrin-containing compound metabolism
- Protoporphyrin-IX biosynthesis
|
| Reactions
|
| 5-Aminolevulinic acid → Porphobilinogen +2 Water |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| Not Available |
| SNPs
| ALAD |
| Gene Sequence
|
>990 bp
ATGCATCCTCAGTCAGTTCTGCACAGCGGCTACTTCCACCCACTGCTCCGGAACTGGCAG
ACAGCCGCCACCAGCCTCAGCGCCTCCAACCTTATCTACCCCATCTTTGTCACGGATGTT
CCTGATGACAAACAGCCCATCGCCAGCCTCCCAGGAGTGGCCAGGTACGGTGTGAACCGG
CTGGAAGAGATGCTGAAACCCCTGGTGGAAGAGGGCCTGCGCTGTGTCCTGATCTTTGGT
GTCCCCAGCAGAGTTCCCAAGGATGAGCGGGGCTCTGCAGCCGACTCCGAGGACTCCCCG
GCTATCGAGGCCATCCGTCTGTTGCGCAAGAATTTCCCCAGCCTCCTGGTGGCCTGTGAC
GTGTGCCTATGTCCCTATACCTCCCACGGTCACTGCGGGCTTCTGAGTGAGAACGGGTCA
TTCCAAGCTGAGGAGAGCCGCCAGCGGCTGGCAGAGGTGGCTCTGGCCTATGCCAAGGCG
GGATGTCAGGTGGTGGCCCCGTCGGACATGATGGACGGACGCGTGGAGGCCATCAAGGAA
GCTCTGATGGCACATGGATTCGGCAACAGGGTATCAGTGATGAGCTATAGTGCCAAATTC
GCTTCTTGTTTCTATGGACCTTTCCGGGACGCGGCTCAGTCGAGCCCGGCTTTTGGAGAT
CGCCGCTGCTACCAGCTGCCACCCGGAGCACGAGGCCTGGCCCTCCGCGCGGTGGACCGG
GATGTTCGGGAGGGAGCAGACTTGCTCATGGTGAAGCCAGGAACGCCCTACCTGGACATC
GTACGGGAGGTAAAGAACAAGCACCCTGAGCTCCCCCTGGCTGTGTACCACGTTTCTGGA
GAGTTTGCCATGCTGTGGCACGGGGCCCAGGCCGGGGCATTTGATCTCAAGGCTGCTGTA
CTAGAGGTCATGACTGCTTTCCGCAGAGCAGGTGCCGATGTCATCATTACCTACTACACA
CCTCAGCTACTGCAGTGGCTGAAGGAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 329 |
| Molecular Weight
| 36081.0 |
| Theoretical pI
| 6.98 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Delta-aminolevulinic acid dehydratase
MHPQSVLHSGYFHPLLRNWQTAATSLSASNLIYPIFVTDVPDDKQPIASLPGVARYGVNR
LEEMLKPLVEEGLRCVLIFGVPSRVPKDERGSAADSEDSPAIEAIRLLRKNFPSLLVACD
VCLCPYTSHGHCGLLSENGSFQAEESRQRLAEVALAYAKAGCQVVAPSDMMDGRVEAIKE
ALMAHGFGNRVSVMSYSAKFASCFYGPFRDAAQSSPAFGDRRCYQLPPGARGLALRAVDR
DVREGADLLMVKPGTPYLDIVREVKNKHPELPLAVYHVSGEFAMLWHGAQAGAFDLKAAV
LEVMTAFRRAGADVIITYYTPQLLQWLKE
|
| External Links |
|---|
| GenBank ID Protein
| AAX46439.1 |
| UniProtKB/Swiss-Prot ID
| Q58DK5 |
| UniProtKB/Swiss-Prot Entry Name
| HEM2_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BT021592 |
| GeneCard ID
| ALAD |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
