| Identification |
|---|
| BMDB Protein ID
| BMDBP00119 |
| Secondary Accession Numbers
| None |
| Name
| Dimethylaniline monooxygenase [N-oxide-forming] 3 |
| Synonyms
|
Not Available
|
| Gene Name
| FMO3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Inorganic ion transport and metabolism |
| Specific Function
| Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 16 |
| Locus
| Not Available |
| SNPs
| FMO3 |
| Gene Sequence
|
>1599 bp
ATGGTGAAGAAAGTGGCCATCATTGGAGCAGGCATCAGTGGCCTGGCCTCCATCAGAAAC
TGCCTAGAAGAGGGACTGGAACCCACCTGCTTTGAGAAGGGTGAAGACATTGGGGGCCTG
TGGAAATTCTCGGACCATGTAGAGGAAGGCAGGGCCAGCATTTATCGGTCAGTCTTTACC
AACTCTTCCAAAGAGATGACATGTTTTCCAGACTTTCCATTTCCTGATGATTTTCCTAAC
TTTATGCACAACAGCAAGCTCCAGGAATATATTACTATGTTTGCCAAAGAAAAGAACCTC
CTGAAATACATACAATTTAAGACAATTGTATCCAGTGTAAATAAGCGTCCCGATTTCCAA
ACCACTGGCCAATGGGATGTTATCACTGAAAAGGATGGTAAAAAGGAATCAGCTGTCTTT
GATGCCGTAATGATTTGTTCTGGACATCATGTGTACCCCAACATACCTAAAGAGTCCTTT
CCAGGAATAAAACTTTTTAAAGGCAAATGCTTCCACAGCCGGGACTATAAAGAACCAGGA
ATCTTCAAGGGGAAGCGAGTCCTGGTGATTGGTCTGGGGAACTCAGGCTGTGACATCGCC
TCAGAACTCAGCCACATAGCTGAAAAAGTCATCATCAGCTCCCGAAGTGGCTCCTGGGTG
ATGAGCCGGGTCTGGGATGAAGGCTATCCATGGGACATGCTGTTTATCACTCGATTTGAA
ACATTCCTCAAGAACACCTTACCGACAGTCATTTCTAACTGGTGGTACATGAAGCAAATG
AACGCCAGATTCAAGCACGAGAACTACGGCTTGATGCCTTTAAACAGCACCCTGAGGAAA
GAGCCTGTGTTCAATGACGAACTCCCAGCTTGCATTTTATGTGGCATTGTGACCATTAAG
CCAAATGTGAAGGAGTTTACAGAGGATTCAGCTATTTTTGAGGATGGGACGGTGTTTAAG
GCCATTGACTATGTCATCTTTGCAACAGGCTATAGTTATGCCTACCCCTTCCTTGATGAC
TCCATCATTAAGAGCAGAGACAATGAGGTCACCTTATTTAAAGGCATCTTCCCACCTCCA
CTGGAAAAGCCAACCTTGGCTGTGATCGGCCTTGTCCAGTCCCTTGGAGCTGCCATCCCC
ACTACTGACCTGCAGTCTCGCTGGGCAGTACAAGTAATTAAGGGAACATGCCCTTTGCCT
TCTGTCAAGGACATGATGAATGATATTGATGAAAAAATGGGGAAAAAGCTCAAATTGTTT
GGCAAAAGTGATACCATACAGACGGATTATGTTGTTTATATGGATGAGCTTGCCTCCTTC
ATTGGGGCAAAGCCCAACATCCCATGGCTGTTTCTCACAGATCCAAAGTTGGCATTGGAG
GTCTACTTTGGCCCTTGCACCCCATACCAGTTTAGGCTGGTGGGCCCAGGAAAGTGGCCA
GGAGCCAGAAACGCCATCCTGACCCAGTGGGACCGGTTACTGAAACCTATGACGACAAGA
GTGGTTGGGAGTCCTCTGAAGCCTTGCTTATTTTGCAACTGGTTCAGACCTGTTCTTATT
TCTGTTGTATCAATTGCTGCTCTCATTGTGTTGTTCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 532 |
| Molecular Weight
| 60093.0 |
| Theoretical pI
| 8.14 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Dimethylaniline monooxygenase [N-oxide-forming] 3
MVKKVAIIGAGISGLASIRNCLEEGLEPTCFEKGEDIGGLWKFSDHVEEGRASIYRSVFT
NSSKEMTCFPDFPFPDDFPNFMHNSKLQEYITMFAKEKNLLKYIQFKTIVSSVNKRPDFQ
TTGQWDVITEKDGKKESAVFDAVMICSGHHVYPNIPKESFPGIKLFKGKCFHSRDYKEPG
IFKGKRVLVIGLGNSGCDIASELSHIAEKVIISSRSGSWVMSRVWDEGYPWDMLFITRFE
TFLKNTLPTVISNWWYMKQMNARFKHENYGLMPLNSTLRKEPVFNDELPACILCGIVTIK
PNVKEFTEDSAIFEDGTVFKAIDYVIFATGYSYAYPFLDDSIIKSRDNEVTLFKGIFPPP
LEKPTLAVIGLVQSLGAAIPTTDLQSRWAVQVIKGTCPLPSVKDMMNDIDEKMGKKLKLF
GKSDTIQTDYVVYMDELASFIGAKPNIPWLFLTDPKLALEVYFGPCTPYQFRLVGPGKWP
GARNAILTQWDRLLKPMTTRVVGSPLKPCLFCNWFRPVLISVVSIAALIVLF
|
| External Links |
|---|
| GenBank ID Protein
| AAN27919.1 |
| UniProtKB/Swiss-Prot ID
| Q8HYJ9 |
| UniProtKB/Swiss-Prot Entry Name
| FMO3_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF488422 |
| GeneCard ID
| FMO3 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
