| Identification |
|---|
| BMDB Protein ID
| BMDBP00122 |
| Secondary Accession Numbers
| |
| Name
| Histamine N-methyltransferase |
| Synonyms
|
Not Available
|
| Gene Name
| HNMT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in histamine N-methyltransferase activity |
| Specific Function
| Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine. |
| Pathways
|
Not Available
|
| Reactions
|
| S-Adenosylmethionine + Histamine → S-Adenosylhomocysteine + 1-Methylhistamine |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 2 |
| Locus
| Not Available |
| SNPs
| HNMT |
| Gene Sequence
|
>879 bp
ATGGCATCTTCCATGAGGAGCCTGTTTACTGACCACAGCAGATACGTTGAGTCTTTCCGG
AGGTTTCTCAGCAATTCCACGGAGCACCAGTGTATGCAGGAATTCATGGACAAGAAGCTG
CCGGGCATAATAGCAAGGATTGGAGACATAAAATCTGAAATTAAGATTCTAAGCATTGGC
GGTGGTGCAGGTGAAATTGACCTTCAAATTCTCTCCAAAGTGCAAGCTCAGTACCCAGGA
GTTCATATCATCAATGAAGTTGTTGAACCAAGTGCTGAACAAATCACCAAGTACAAAGAG
CTTGTAGCAAAGACATCAAACCTTGAGAACATAAAGTTTGCTTGGCATAAAGAGACATCA
TCTGAATATCAAAATAGAATGATGGAGAAAAAAGAACTTCAGAGGTGGGACTTTATTCAT
ATGATTCAGATGCTGTATTATGTTAAAGACATCCCAGCTACCCTGAAATTCTTCCATAGT
CTCTTAGCTACCAATGCTAAGATTCTCATTATTATTGTGTCAGGAGCCAGCAGCTGGCAA
AAGCTATGGGAAAAGTATGGATCTCGCTTACCCCGGAATGACCTCTGCCAGTATGTCACA
TCATCTGACCTCACTCAGATGCTGGATAAGTTGGGGATTAAGTACGAGTATTATGACCTT
CTGTCCACCATGGACATATCTGACTGTTTTATTGATGGCAATGAAAATGGAGACCTGCTT
TGGGATTTTTTGACCGAAACCTGCAATTTTAATACAACAGCACCACCTGATCTCAAAGCA
GAAATTATGAAAGATCTGCAAAAGCCTGAATTCAGTATAAAGAAAGAGGGAAAGGTTCTT
TTCAATAACAGTCTGAGTTTCATAGTGGTTGAGGCATAA
|
| Protein Properties |
|---|
| Number of Residues
| 292 |
| Molecular Weight
| 33646.0 |
| Theoretical pI
| 5.99 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Histamine N-methyltransferase
MASSMRSLFTDHSRYVESFRRFLSNSTEHQCMQEFMDKKLPGIIARIGDIKSEIKILSIG
GGAGEIDLQILSKVQAQYPGVHIINEVVEPSAEQITKYKELVAKTSNLENIKFAWHKETS
SEYQNRMMEKKELQRWDFIHMIQMLYYVKDIPATLKFFHSLLATNAKILIIIVSGASSWQ
KLWEKYGSRLPRNDLCQYVTSSDLTQMLDKLGIKYEYYDLLSTMDISDCFIDGNENGDLL
WDFLTETCNFNTTAPPDLKAEIMKDLQKPEFSIKKEGKVLFNNSLSFIVVEA
|
| External Links |
|---|
| GenBank ID Protein
| AAX46337.1 |
| UniProtKB/Swiss-Prot ID
| Q58DV7 |
| UniProtKB/Swiss-Prot Entry Name
| HNMT_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT021490 |
| GeneCard ID
| HNMT |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
