| Identification |
|---|
| BMDB Protein ID
| BMDBP00132 |
| Secondary Accession Numbers
| None |
| Name
| ADP-ribose glycohydrolase ARH3 |
| Synonyms
|
Not Available
|
| Gene Name
| ADPRS |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Posttranslational modification, protein turnover, chaperones |
| Specific Function
| ADP-ribose glycohydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on serine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose. Specifically acts as a serine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. Does not hydrolyze ADP-ribosyl-arginine, -cysteine, -diphthamide, or -asparagine bonds. Also able to degrade protein free poly(ADP-ribose), which is synthesized in response to DNA damage: free poly(ADP-ribose) acts as a potent cell death signal and its degradation by ADPRHL2 protects cells from poly(ADP-ribose)-dependent cell death, a process named parthanatos. Also hydrolyzes free poly(ADP-ribose) in mitochondria. Specifically digests O-acetyl-ADP-D-ribose, a product of deacetylation reactions catalyzed by sirtuins. Specifically degrades 1''-O-acetyl-ADP-D-ribose isomer, rather than 2''-O-acetyl-ADP-D-ribose or 3''-O-acetyl-ADP-D-ribose isomers. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| Not Available |
| SNPs
| ADPRS |
| Gene Sequence
|
>1098 bp
ATGGCGGCGGCGGCAGCGATGACGGCGGCGGGCTGCGGAGGGGCTGGGGCGGCACGCTCC
CTCTCCCGCTTCCGAGGCTGCCTGGCAGGCGCGCTGCTCGGGGACTGCGTGGGCGCCGTC
TACGAGGCGCGCGACACCGTCGACCTGACGTCAGTCCTGCGTCAGGTCCAGGATTTGGAG
CCGGACCCCGGCTCTCCCGGGAGCGCGCGGACAGAAGCACTGTGCTACACGGACGACACA
GCCATGGCCAGGGCGCTGGTGCAGTCCCTGCTGGCCAAGGAGGCCTTCGACGAGGTGGAC
ATGGCTCACAGGTTTGCTCAGGAGTACAAGAAGGACCCTGACCGGGGTTACGGTGCTGGA
GTGATCACCGTCTTCAGGAAACACCTAAGCCCCAGATGCCGGGATGTCTTTGAGCCTGCA
CGCGCCCAGTTCAATGGCAAAGGCTCCTACGGCAACGGGGGTGCCATGCGGGTGGCCGGC
ATCTCCCTGGCCTATAGCAGCGTGCAGGATGTGCAGAAGTTCGCCCGGCTCTCGGCCCAG
CTGACACACGCCTCCTCCCTGGGTTACAATGGTGCCATCCTGCAGGCCCTGGCTGTGCAC
CTGGCCTTGCAGGGCGAGTCGTCCAGTGAGCACTTCCTCGAGCAGCTCCTTGGCCACATG
GAAGAGCTGGAGAGTGATGCCCAGTCCGTGCTGGATGCCAGGGAGTTGGGCATGGAGGAG
CGTCCGTACTCCAGCCGACTGAAGAAGATCGGGGAGCTTCTAGAGCAGGACTCAGTGACC
AGAGAGGAGGTGGTGTCCGAGCTAGGAAATGGCATTGCTGCCTTTGAATCTGTGCCCACC
GCCATCTATTGCTTCCTGCGCTGCATGGAGCCCGACCCCGAGATCCCCTCTACCTTCAAC
AGCCTCCAAAGGACTCTCGTCTATTCCATCTCGCTCGGTGGGGACACGGACACCATTGCC
ACCATGGCCGGGGCCATTGCTGGCGCCTACTATGGGATGGAACAGGTGCCAGAGAGCTGG
CAGCAAAGCTGTGAAGGCTATGAGGAGACTGACGTCCTGGCCCAGAGCCTGCACCGGGTC
TTCCAGAAGAGTCTTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 365 |
| Molecular Weight
| 39221.0 |
| Theoretical pI
| 4.56 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Poly(ADP-ribose) glycohydrolase ARH3
MAAAAAMTAAGCGGAGAARSLSRFRGCLAGALLGDCVGAVYEARDTVDLTSVLRQVQDLE
PDPGSPGSARTEALCYTDDTAMARALVQSLLAKEAFDEVDMAHRFAQEYKKDPDRGYGAG
VITVFRKHLSPRCRDVFEPARAQFNGKGSYGNGGAMRVAGISLAYSSVQDVQKFARLSAQ
LTHASSLGYNGAILQALAVHLALQGESSSEHFLEQLLGHMEELESDAQSVLDARELGMEE
RPYSSRLKKIGELLEQDSVTREEVVSELGNGIAAFESVPTAIYCFLRCMEPDPEIPSTFN
SLQRTLVYSISLGGDTDTIATMAGAIAGAYYGMEQVPESWQQSCEGYEETDVLAQSLHRV
FQKSL
|
| External Links |
|---|
| GenBank ID Protein
| AAI03361.1 |
| UniProtKB/Swiss-Prot ID
| Q3SYV9 |
| UniProtKB/Swiss-Prot Entry Name
| ADPRS_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC103360 |
| GeneCard ID
| ADPRS |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
