| Identification |
|---|
| BMDB Protein ID
| BMDBP00142 |
| Secondary Accession Numbers
| None |
| Name
| [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| BCKDK |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Signal transduction mechanisms |
| Specific Function
| Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex. |
| Pathways
|
- Fc Epsilon Receptor I Signaling in Mast Cells
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 25 |
| Locus
| Not Available |
| SNPs
| BCKDK |
| Gene Sequence
|
>1239 bp
ATGATACTGGCTTCGGTGCTGGGGAGCGGACCCCGGGGCGGGCCACCCCTCCGGCCTCTC
TTGGGGCCCGCACTCTCGCTCCGGGCCCGCTCCACATCAGCCACTGATACCCACCATGTG
GAAATGGCACGGGAGCGCTCTAAGACCGTCACCTCCTTTTACAACCAGTCAGCCATTGAC
GTCGCAGCGGAGAAGCCTTCAGTCCGCCTCACTCCAACCATGATGCTCTATTCAGGCCGC
TCCCAGGATGGCAGTCACCTCCTGAAAAGTGCCCGCTACTTGCAGCAGGAGTTGCCAGTG
AGGATCGCTCACCGCATCAAGGGCTTCCGCAGCCTTCCTTTCATCATTGGCTGCAACCCC
ACCATACTGCACGTGCACGAGCTGTACATCCGTGCCTTCCAGAAGCTGACAGACTTCCCT
CCGATCAAGGACCAGGCGGATGAGGCCCGATACTGCCAGCTGGTGCGACAGCTGTTGGAT
GACCACAAGGACGTGGTGACCCTCTTAGCGGAAGGCCTGCGTGAGAGCCGGAAGTACATA
GAGGATGAGAAGCTCGTCCGTTACTTCTTAGACAAGACGTTGACTTCAAGGCTTGGGATC
CGTATGTTGGCCACCCACCATCTGGCACTACATGAGGACAAGCCCGACTTTGTTGGCATC
ATCTGCACTCGCCTGTCACCGAAGAAGATTATTGAAAAGTGGGTGGACTTTGCCAGACGC
CTGTGTGAGCACAAGTATGGCAATGCACCCCGAGTCCGCATCAACGGACACGTGGCTGCC
CGTTTCCCCTTCATCCCAATGCCACTGGACTACATCCTACCTGAGCTGCTCAAGAACGCC
ATGAGAGCCACAATGGAGAGTCACCTCGACACTCCCTACAATGTCCCAGATGTCGTCATC
ACCATCGCCAACAATGATATCGATCTCGTCATCAGGATTTCAGACCGGGGCGGGGGAATT
GCTCACAAAGACCTGGATCGGGTGATGGACTACCACTTCACTACAGCTGAGGCCAGCACC
CAGGACCCCCGGATCAGCCCCCTCTTTGGCCACCTGGACTTGCACAGTGGTGGCCAGTCA
GGACCCATGCACGGCTTTGGCTTCGGGCTGCCCACTTCGCGGGCCTACGCAGAGTACCTC
GGTGGTTCCCTTCGGCTGCAGTCGCTGCAGGGCATTGGCACAGATGTCTACCTACGGCTC
CGTCACATCGATGGCCGGGAAGAAAGCTTCCGCATCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 412 |
| Molecular Weight
| 46438.0 |
| Theoretical pI
| 9.48 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial
MILASVLGSGPRGGPPLRPLLGPALSLRARSTSATDTHHVEMARERSKTVTSFYNQSAID
VAAEKPSVRLTPTMMLYSGRSQDGSHLLKSARYLQQELPVRIAHRIKGFRSLPFIIGCNP
TILHVHELYIRAFQKLTDFPPIKDQADEARYCQLVRQLLDDHKDVVTLLAEGLRESRKYI
EDEKLVRYFLDKTLTSRLGIRMLATHHLALHEDKPDFVGIICTRLSPKKIIEKWVDFARR
LCEHKYGNAPRVRINGHVAARFPFIPMPLDYILPELLKNAMRATMESHLDTPYNVPDVVI
TIANNDIDLVIRISDRGGGIAHKDLDRVMDYHFTTAEASTQDPRISPLFGHLDLHSGGQS
GPMHGFGFGLPTSRAYAEYLGGSLRLQSLQGIGTDVYLRLRHIDGREESFRI
|
| External Links |
|---|
| GenBank ID Protein
| AAI05353.1 |
| UniProtKB/Swiss-Prot ID
| Q2KJG8 |
| UniProtKB/Swiss-Prot Entry Name
| BCKD_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC105352 |
| GeneCard ID
| BCKDK |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
