| Identification |
|---|
| BMDB Protein ID
| BMDBP00146 |
| Secondary Accession Numbers
| None |
| Name
| Activin receptor type-2A |
| Synonyms
|
Not Available
|
| Gene Name
| ACVR2A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in activin receptor activity |
| Specific Function
| On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 2 |
| Locus
| 2q23-q24 |
| SNPs
| ACVR2A |
| Gene Sequence
|
>1542 bp
ATGGGAGCCGCTGCAAAGTTGGCGTTTGCCGTCTTTCTTATCTCTTGTTCTTCAGGTGCT
ATACTTGGTAGATCAGAAACTCAGGAGTGTATTTTCTATAATGCTAATTGGGAAAGAGAT
AGAACGAATCGCACTGGTGTTGAATCCTGTTACGGTGACAAAGATAAACGGCGGCATTGT
TTTGCTACATGGAAGAATATTTCTGGTTCCATTGAAATAGTGAAGCAAGGTTGTTGGCTG
GATGATATCAACTGCTATGACAGGACTGATTGTATAGAAAAAAAAGATAGCCCTGAAGTA
TATTTTTGTTGCTGTGAGGGCAATATGTGTAACGAAAGGTTTTCTTATTTTCCGGAGATG
GAGGTCACACAGCCTACGTCGAATCCAGTAACTCCTAAGCCTCCCTATTACAACATCTTG
CTCTATTCTTTGGTGCCACTTATGTTAATTGCGGGGATTGTCATTTGTGCATTTTGGGTG
TACAGACATCATAAGATGGCTTACCCTCCTGTGCTCGTTCCAACTCAAGACCCAGGACCA
CCCCCACCTTCTCCATTACTAGGTTTGAAGCCATTACAGTTACTAGAAGTGAAAGCAAGA
GGAAGATTTGGTTGTGTGTGGAAAGCCCAGTTACTCAATGAATATGTGGCTGTGAAAATA
TTTCCAATACAGGATAAACAGTCATGGCAGAATGAATATGAAGTCTATAGTTTGCCTGGA
ATGAAGCATGAGAACATACTGCAGTTCATTGGTGCAGAGAAACGAGGCACCAGTGTTGAT
GTGGATCTTTGGCTAATCACAGCATTTCATGAAAAGGGTTCACTATCAGACTTTCTTAAG
GCTAATGTGGTCTCTTGGAATGAATTGTGTCATATTGCAGAAACCATGGCTAGAGGATTG
GCATATTTACATGAGGATATACCTGGCCTAAAAGATGGCCACAAACCCGCCATATCTCAC
AGGGACATCAAAAGTAAAAATGTGCTGTTGAAAAACAATCTGACAGCCTGCATTGCTGAC
TTTGGGTTGGCGTTGAAGTTTGAGGCTGGCAAGTCTGCAGGTGATACTCATGGACAGGTG
GGTACCCGAAGGTATATGGCTCCAGAGGTGTTAGAGGGTGCTATCAACTTCCAAAGGGAT
GCATTTTTGAGGATAGATATGTACGCCATGGGATTAGTCCTGTGGGAACTGGCTTCTCGC
TGTACTGCTGCAGATGGACCTGTAGATGAATACATGCTGCCATTTGAGGAAGAAATTGGC
CAGCATCCCTCTCTTGAAGACATGCAGGAAGTTGTTGTGCATAAAAAAAAGAGGCCTGTT
TTAAGAGATTATTGGCAGAAACATGCTGGAATGGCAATGCTCTGTGAAACGATAGAAGAA
TGTTGGGATCACGATGCAGAAGCCAGGTTATCAGCTGGATGTGTAGGTGAAAGAATTACT
CAGATGCAAAGACTAACAAATATCATTACCACAGAGGACATTGTAACAGTGGTCACGATG
GTGACAAATGTTGACTTTCCTCCCAAAGAATCTAGTCTATGA
|
| Protein Properties |
|---|
| Number of Residues
| 513 |
| Molecular Weight
| 57952.0 |
| Theoretical pI
| 5.9 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Activin receptor type-2A
MGAAAKLAFAVFLISCSSGAILGRSETQECIFYNANWERDRTNRTGVESCYGDKDKRRHC
FATWKNISGSIEIVKQGCWLDDINCYDRTDCIEKKDSPEVYFCCCEGNMCNERFSYFPEM
EVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGP
PPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPG
MKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGL
AYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQV
GTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIG
QHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERIT
QMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL
|
| External Links |
|---|
| GenBank ID Protein
| AAA74597.1 |
| UniProtKB/Swiss-Prot ID
| Q28043 |
| UniProtKB/Swiss-Prot Entry Name
| AVR2A_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| L21717 |
| GeneCard ID
| ACVR2A |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
