<?xml version="1.0" encoding="UTF-8"?>
<protein>
  <version>1.0</version>
  <creation_date>2018-05-07 22:21:05 UTC</creation_date>
  <update_date>2020-05-20 20:59:43 UTC</update_date>
  <accession>BMDBP00156</accession>
  <secondary_accessions>
  </secondary_accessions>
  <protein_type>Enzyme</protein_type>
  <synonyms>
  </synonyms>
  <gene_name>ENTPD8</gene_name>
  <general_function/>
  <specific_function>Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP (By similarity).</specific_function>
  <pathways>
    <pathway>
      <name>Purine Metabolism</name>
      <smpdb_id>SMP0087239</smpdb_id>
      <kegg_map_id/>
    </pathway>
  </pathways>
  <metabolite_associations>
    <metabolite>
      <accession>BMDB0000464</accession>
      <name>Calcium</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0001429</accession>
      <name>Phosphate</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0003335</accession>
      <name>IDP</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0002111</accession>
      <name>Water</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0000175</accession>
      <name>Inosinic acid</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0000973</accession>
      <name>Hydrogen phosphate</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0000189</accession>
      <name>Inosine triphosphate</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0001273</accession>
      <name>Guanosine triphosphate</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0001201</accession>
      <name>Guanosine diphosphate</name>
    </metabolite>
  </metabolite_associations>
  <go_classifications>
  </go_classifications>
  <subcellular_locations>
  </subcellular_locations>
  <gene_properties>
    <chromosome_location/>
    <locus/>
    <gene_sequence>&gt;1488 bp
ATGGGGCTGACCTGGAAGCAGCGGGTCTTCACGGCTCTGCTGGGCGCAGCAGCGGTCTCA
GGCCTCACCGCGCTGCTTCTCGTCCTGGTGGGGACCATGAACGTCCTCCTGCCTCCAGAC
ACCAAGTTTGGGATCGTGTTCGACGCTGGGTCCTCCCACACATCCCTCTTTGTGTATCAG
TGGCCGGCCAACAAGGAGAACGACACCGGCATAGTCAGCCAGGCCCTGGCCTGCCAGGCG
GAAGGGCCTGGAATCTCGTCTTACGCCTCCAACCCTGCGCGGGTTGGCGAGAGCCTGCAG
GGCTGCCTGGAGGAGGCGCTAGCACTGATCCCAAAGGCCAAGCATCATGAGACACCCATG
TTCCTGGGGGCCACTGCAGGCATGCGGCTGCTCAGCCGCAAGAATCGCTCCCAGGCGGAG
GACGTGTTCGCCGCGGTCAGCCGGGCCCTGGGCCAGTCACCGGTGGACTTCCGGGGCGCA
GAGCTCCTGACGGGGCAGGACGAAGGCGCCTTTGGTTGGATCACCATCAACTACATCCTT
GGCCTGCTGGTGAAGTACTCCTTCTCTGGAGAGTGGATCCGGCCCCTGGAGGAGACGCTG
GTGGGCGCCCTGGACATGGGTGGGGCCTCCACCCAGATTACCTTTGTACCTGGAGGCCCC
ATCCTGGACAAGACCGCCCAGGCCACCTTCCGCCTCTACGGTGCCGACCACACCGTCTAC
ACCCACAGCTACCTCTGCTTCGGGCGCGACCAGGCGCTGAGCAGGGTGCTGGCCGAGCTG
GTGCAGGCCAGCACGGGCCTCCTGATCCGCCACCCCTGCTACCACAGCGGCTACCGGGGC
ACGCTGGCCCTGGCGTCCCTGTATGAGTCGCCCTGCGCCCCGGCAGCGCCCCCCGACCTC
AGCCAGAACCTCACCGTGGAGGGCACGGGGAACCCCGGGGCCTGCGTCGAGGCCCTCCGG
AAGCTCTTCAATTTCTCCAGCTGTGACGGCCGAGAAGACTGTGCCTTCGCCGGGGTCTAC
CAGCCCCCCGTGCAGGGCCAGTTCTACGCTTTCTCCAACTTCTACTACACCTTCAACTTC
CTGAACCTCACCTCCAAGCCGTCACTGAGTGGGGCCAACGCCACCATCTGGGAGTTCTGC
CTGCGGCCCTGGAAGCTGGTGGAGGCGAGCGCGCCCCCGGGCCAGGACCGCTGGCTGCGG
GACTACTGTGCCTCGGGCCTATACATCCTCACGCTCCTGGTCGAGGGCTACGGGTTCAGT
GAGGAGACCTGGGGAGGCATCGAGTTCCGCCAGCAGGCCGGCGGCGCTGACATCGGCTGG
ACGCTGGGCTACATGCTGAACCTGACCAACCTGATCCCGGCCGAGGCGCCCGCCCAGGGT
TGGGCACAGAGCTTCGGCGTCTGGGCGGCCGGGGTCGTCTTCGTGGTGCTGACGCTCGCG
GCCACCCTGGGTGCCGTGGCAGTGCAGGTCTTCTGGCTCCAGGACTAG</gene_sequence>
  </gene_properties>
  <protein_properties>
    <residue_number>495</residue_number>
    <molecular_weight>53240.0</molecular_weight>
    <theoretical_pi>4.97</theoretical_pi>
    <pfams>
    </pfams>
    <transmembrane_regions>
      <region>9-29</region>
      <region>467-487</region>
    </transmembrane_regions>
    <signal_regions>
      <region>None</region>
    </signal_regions>
    <polypeptide_sequence>&gt;Ectonucleoside triphosphate diphosphohydrolase 8
MGLTWKQRVFTALLGAAAVSGLTALLLVLVGTMNVLLPPDTKFGIVFDAGSSHTSLFVYQ
WPANKENDTGIVSQALACQAEGPGISSYASNPARVGESLQGCLEEALALIPKAKHHETPM
FLGATAGMRLLSRKNRSQAEDVFAAVSRALGQSPVDFRGAELLTGQDEGAFGWITINYIL
GLLVKYSFSGEWIRPLEETLVGALDMGGASTQITFVPGGPILDKTAQATFRLYGADHTVY
THSYLCFGRDQALSRVLAELVQASTGLLIRHPCYHSGYRGTLALASLYESPCAPAAPPDL
SQNLTVEGTGNPGACVEALRKLFNFSSCDGREDCAFAGVYQPPVQGQFYAFSNFYYTFNF
LNLTSKPSLSGANATIWEFCLRPWKLVEASAPPGQDRWLRDYCASGLYILTLLVEGYGFS
EETWGGIEFRQQAGGADIGWTLGYMLNLTNLIPAEAPAQGWAQSFGVWAAGVVFVVLTLA
ATLGAVAVQVFWLQD</polypeptide_sequence>
  </protein_properties>
  <genbank_protein_id>AAI26638.1</genbank_protein_id>
  <uniprot_id>A0JND9</uniprot_id>
  <uniprot_name>ENTP8_BOVIN</uniprot_name>
  <pdb_ids>
  </pdb_ids>
  <genbank_gene_id>BC126637</genbank_gene_id>
  <genecard_id>ENTPD8</genecard_id>
  <geneatlas_id/>
  <general_references>
  </general_references>
  <metabolite_references>
  </metabolite_references>
</protein>
