| Identification |
|---|
| BMDB Protein ID
| BMDBP00158 |
| Secondary Accession Numbers
| None |
| Name
| Sodium/potassium-transporting ATPase subunit alpha-2 |
| Synonyms
|
Not Available
|
| Gene Name
| ATP1A2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Inorganic ion transport and metabolism |
| Specific Function
| This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients (By similarity). |
| Pathways
|
- Kidney Function
- Trehalose Degradation
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| Not Available |
| SNPs
| ATP1A2 |
| Gene Sequence
|
>3063 bp
ATGGGCCGTGGGGCTGGCCGCGAGTACTCGCCTGCAGCCACCACTGCGGAAAATGGGGGC
GGCAAGAAGAAACAGAAAGAGAAGGAGCTGGATGAGCTGAAGAAGGAAGTGGCCATGGAT
GACCACAAGCTGTCCTTGGATGAGCTGGGCCGCAAGTACCAAGTGGATCTGTCCAAGGGC
CTCACCAACCAGCGGGCCCAGGACATTCTGGCTCGGGATGGACCCAATGCCCTCACCCCA
CCCCCAACCACCCCTGAGTGGGTCAAGTTCTGTCGTCAGCTTTTCGGGGGCTTCTCCATC
CTACTGTGGATTGGGGCCATCCTCTGCTTCCTGGCCTTTGGCATCCAGGCTGCCATGGAG
GATGAACCGTCCAACGACAATCTTTATCTGGGCGTGGTGCTGGCAGCTGTGGTCATCGTC
ACTGGCTGCTTCTCCTACTACCAGGAGGCCAAGAGCTCCAAGATCATGGATTCCTTCAAG
AACATGGTGCCTCAGCAAGCCCTTGTGGTGCGAGAAGGAGAGAAGATGCAGATCAACGCG
GAGGAGGTGGTGGTGGGCGACCTGGTGGAGGTGAAGGGTGGGGACCGCGTGCCCGCTGAC
CTCCGGATCATCTCTTCTCACGGCTGCAAGGTGGACAACTCCTCCCTGACAGGCGAGTCA
GAACCCCAGACCCGCTCCCCTGAGTTCACCCACGAGAATCCCCTGGAGACCCGCAATATC
TGTTTCTTCTCTACCAACTGTGTGGAAGGCACTGCCAGGGGCATCGTGATTGCCACAGGT
GACCGGACGGTGATGGGCCGTATAGCCACTCTGGCCTCAGGCCTGGAGGTCGGGCGGACG
CCCATAGCCATGGAGATTGAGCACTTCATTCAGCTGATCACAGGGGTGGCCGTCTTCCTG
GGGGTCTCCTTCTTCGTGCTGTCCCTCATCCTGGGCTACAGCTGGCTGGAGGCGGTCATC
TTCCTTATCGGCATCATTGTGGCCAACGTGCCTGAGGGTCTGCTGGCCACTGTCACCGTG
TGTCTGACCCTGACAGCCAAGCGCATGGCTCGGAAGAACTGCCTGGTGAAGAACCTGGAG
GCGGTGGAGACTCTGGGCTCCACCTCCACCATCTGCTCCGACAAGACCGGAACCCTCACC
CAGAACCGCATGACCGTCGCCCACATGTGGTTCGACAATCAGATCCATGAGGCCGACACC
ACGGAAGATCAGTCTGGGGCCACTTTTGACAAACGATCCCCGACATGGACTGCCCTATCC
CGGATTGCTGGTCTCTGCAACCGTGCTGTGTTCAAGGCAGGGCAGGAAAACATCTCTGTG
TCTAAGCGGGACACAGCAGGTGATGCCTCCGAGTCAGCTCTCCTCAAGTGCATTGAGCTG
TCCTGCGGCTCCGTGAGGAAGATGAGGGATAGAAACCCCAAGGTGGCAGAGATCCCTTTC
AACTCAACCAATAAGTACCAGCTGTCCATCCACGAGCGAGAAGACAGCCCCCAGAGCCAC
GTGCTGGTGATGAAGGGGGCCCCTGAGCGCATCCTGGACCGTTGCTCCTCCATCCTGGTG
CAGGGCAAGGAGATCCCTCTGGACAAGGAGATGCAAGATGCCTTCCAGAATGCCTACCTG
GAGCTGGGAGGGCTCGGGGAGCGCGTCCTGGGCTTCTGTCAACTGAATCTGCCTTCTGCA
AAGTTTCCTCGGGGCTTCAAATTTGACACGGATGAGCTGAACTTTCCCACAGAGAAGCTC
TGCTTCGTGGGGCTCATGTCCATGATTGACCCTCCACGGGCTGCCGTTCCCGATGCTGTG
GGCAAGTGCCGGAGTGCAGGCATCAAGGTGATCATGGTGACCGGTGACCACCCCATCACA
GCCAAGGCCATTGCCAAAGGCGTGGGCATCATCTCAGAAGGCAACGAGACAGTGGAGGAC
ATTGCCGCCCGGCTCAACATTCCTGTTAGCCAAGTCAACCCCAGAGAAGCCAAGGCGTGT
GTGGTGCACGGCTCTGACCTGAAAGATATGACGTCGGAGCAGCTGGACGAGATCCTCAAG
AATCACACGGAGATCGTCTTTGCCCGGACGTCTCCTCAGCAGAAGCTCATCATCGTGGAG
GGCTGCCAGAGGCAGGGAGCCATTGTGGCGGTGACGGGGGATGGGGTGAATGACTCCCCG
GCGCTAAAGAAGGCGGACATTGGCATCGCCATGGGCATCGCTGGCTCCGACGTTTCTAAG
CAGGCCGCCGACATGATCCTGCTGGATGACAACTTTGCCTCCATCGTCACTGGCGTGGAG
GAGGGCCGCCTGATCTTTGACAACCTGAAGAAATCCATCGCCTACACCCTGACCAGTAAC
ATCCCCGAGATCACCCCTTTCCTGCTGTTCATCATCGCCAACATCCCCCTGCCTCTGGGC
ACCGTGACCATCCTCTGCATTGACCTGGGCACTGATATGGTCCCTGCCATCTCCTTGGCC
TATGAGGCAGCTGAGAGTGACATCATGAAGCGGCAGCCACGCAACCCGCAGACGGACAAG
CTGGTGAACGAGAGGCTCATCAGCATGGCCTATGGACAGATCGGGATGATCCAGGCTCTG
GGTGGCTTCTTCACCTACTTTGTGATCCTGGCAGAGAATGGTTTTCTACCTTCGCGGCTT
CTGGGAATCCGCCTGGACTGGGATGACCGGTCCATGAATGACTTGGAGGACAGCTACGGA
CAGGAGTGGACCTATGAACAGCGGAAGGTGGTGGAGTTCACATGCCACACGGCTTTCTTT
GCCAGCATTGTGGTCGTGCAATGGGCTGACCTCATCATCTGCAAGACCCGCCGCAACTCA
GTTTTCCAGCAGGGAATGAAAAACAAGATTCTGATTTTTGGGCTCCTGGAGGAGACAGCA
CTGGCGGCCTTTCTGTCTTACTGCCCGGGCATGGGCGTGGCTCTCCGAATGTACCCGCTC
AAGGTCACCTGGTGGTTCTGCGCCTTCCCCTACAGTCTCCTTATCTTCATCTACGATGAG
GTCCGAAAGCTGATCCTGCGGCGATATCCGGGTGGCTGGGTGGAGAAGGAGACCTACTAC
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 1020 |
| Molecular Weight
| 112179.0 |
| Theoretical pI
| 5.33 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 86-106
- 130-150
- 287-306
- 319-336
- 770-789
- 800-820
- 841-863
- 916-935
- 949-967
- 983-1003
|
| Protein Sequence
|
>Sodium/potassium-transporting ATPase subunit alpha-2
MGRGAGREYSPAATTAENGGGKKKQKEKELDELKKEVAMDDHKLSLDELGRKYQVDLSKG
LTNQRAQDILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAFGIQAAME
DEPSNDNLYLGVVLAAVVIVTGCFSYYQEAKSSKIMDSFKNMVPQQALVVREGEKMQINA
EEVVVGDLVEVKGGDRVPADLRIISSHGCKVDNSSLTGESEPQTRSPEFTHENPLETRNI
CFFSTNCVEGTARGIVIATGDRTVMGRIATLASGLEVGRTPIAMEIEHFIQLITGVAVFL
GVSFFVLSLILGYSWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLE
AVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGATFDKRSPTWTALS
RIAGLCNRAVFKAGQENISVSKRDTAGDASESALLKCIELSCGSVRKMRDRNPKVAEIPF
NSTNKYQLSIHEREDSPQSHVLVMKGAPERILDRCSSILVQGKEIPLDKEMQDAFQNAYL
ELGGLGERVLGFCQLNLPSAKFPRGFKFDTDELNFPTEKLCFVGLMSMIDPPRAAVPDAV
GKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPREAKAC
VVHGSDLKDMTSEQLDEILKNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSP
ALKKADIGIAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSN
IPEITPFLLFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPQTDK
LVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPSRLLGIRLDWDDRSMNDLEDSYG
QEWTYEQRKVVEFTCHTAFFASIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLLEETA
LAAFLSYCPGMGVALRMYPLKVTWWFCAFPYSLLIFIYDEVRKLILRRYPGGWVEKETYY
|
| External Links |
|---|
| GenBank ID Protein
| AAI33298.1 |
| UniProtKB/Swiss-Prot ID
| A2VDL6 |
| UniProtKB/Swiss-Prot Entry Name
| AT1A2_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC133297 |
| GeneCard ID
| ATP1A2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
