| Identification |
|---|
| BMDB Protein ID
| BMDBP00175 |
| Secondary Accession Numbers
| None |
| Name
| ATP-citrate synthase |
| Synonyms
|
Not Available
|
| Gene Name
| ACLY |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. |
| Pathways
|
- LPS and Citrate Signaling and Inflammation
- Transfer of Acetyl Groups into Mitochondria
|
| Reactions
|
| Coenzyme A + Citric acid + Adenosine triphosphate → Oxalacetic acid + ADP + Acetyl-CoA |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| Not Available |
| SNPs
| ACLY |
| Gene Sequence
|
>3276 bp
ATGTCGGCCAAGGCGATTTCTGAGCAGACAGGCAAAGAGCTCCTCTACAAGTACATCTGC
ACCACCTCGGCCATCCAGAACCGCTTCAAGTATGCCCGGGTCACCCCTGACACAGACTGG
GCCCGCCTGTTGCAGGACCACCCGTGGCTGCTCAGCCAGAGCTTGGTGGTCAAGCCAGAC
CAGCTGATCAAACGGCGTGGAAAGCTGGGCCTAATTGGGGTCAACCTCACTCTGGATGGA
GTCAAGTCCTGGCTGAAGCCACGCCTGGGACAGGAAGCTACAGTTGGCAAGGCCACAGGC
TTCCTCAAGAACTTCCTGATCGAACCCTTCGTCCCCCACACTCAGGAGGAAGAGTTCTAC
GTCTGCATCTATGCTACCCGAGAAGGGGACTATGTCCTGTTCCACCACGAGGGTGGGGTG
GACGTGGGCGACGTGGATGCTAAAGCCCAGAAACTACTTGTCGGCGTCGATGAGAAGCTG
AATCCTGAGGACATCAAGAAACACCTGCTGGTCCACGCCCCCGAAGACAAGAAAGAAATT
CTGGCCAGCTTTATCTCCGGCCTCTTCAATTTCTATGAGGATCTGTACTTCACCTACCTC
GAGATCAACCCCCTTGTCGTGACCAAAGATGGCGTCTACGTCCTTGACTTGGCCGCCAAG
GTGGATGCCACTGCCGACTACATCTGCAAAGTGAAGTGGGGTGACATAGAGTTCCCACCC
CCCTTCGGACGGGAGGCTTACCCAGAGGAAGCCTACATCGCAGATCTGGACGCCAAAAGT
GGGGCAAGCTTGAAGCTGACTTTACTGAATCCCAAGGGGAGAATCTGGACCATGGTGGCC
GGAGGGGGTGCCTCTGTCGTGTACAGTGACACCATCTGCGACCTGGGGGGTGTCAACGAG
CTGGCAAACTACGGGGAGTACTCGGGCGCCCCCAGCGAGCAGCAGACCTATGACTACGCC
AAGACGATCCTCTCCCTTATGACCCGCGAGAAGCACCCAGATGGCAAGATCCTCATCATC
GGAGGCAGCATCGCAAACTTCACCAACGTGGCTGCCACATTCAAGGGCATCGTGAGAGCA
ATTCGAGATTACCAGGGTCCCCTGAAGGAGCACGAGGTCACGATCTTTGTCCGAAGAGGT
GGCCCCAACTATCAGGAGGGCTTACGGGTCATGGGAGAAGTCGGGAAGACCACTGGGATC
CCCATCCATGTCTTCGGCACTGAGACTCACATGACGGCCATCGTGGGCATGGCCCTGGGC
CATCGGCCCATCCCCAATCAGCCGCCCACAGCGGCCCACACCGCAAACTTCCTCCTCAAC
GCCAGCGGGAGTACTTCAACTCCAGCCCCCAGCAGGACGGCATCTTTTTCTGAGTCCAGA
ACTGATGAGGTGGCCCCTGCCAAGAAGGCCAAGCCTGCCATGCTCCAAGGAAAGAGCGCC
ACCCTCTTCAGCCGCCACACCAAGGCCATCGTGTGGGGCATGCAGACCCGGGCTGTGCAG
GGCATGCTGGACTTCGACTACGTCTGCTCCCGCGACGAGCCCTCAGTGGCTGCCATGGTC
TACCCGTTCACTGGGGACCACAAACAGAAGTTTTACTGGGGTCACAAGGAGATCCTGATC
CCCGTCTTTAAGAACATGGCTGATGCCATGAAGAAGCACCCAGAGGTAGACGTGCTAATC
AACTTTGCCTCCCTGCGCTCAGCCTACGACAGCACCATGGAGACCATGAATTACGCTCAG
ATCCGGACCATCGCCATCATAGCCGAAGGCATCCCTGAGGCGCTCACGAGGAAGCTGATC
AAGAAGGCAGACCAGAAGGGAGTGACCATCATTGGACCTGCCACCGTTGGTGGCATCAAG
CCCGGGTGCTTTAAGATCGGGAACACCGGCGGGATGCTGGACAACATCCTGGCCTCTAAG
CTGTACCGCCCAGGCAGTGTGGCCTATGTCTCGCGTTCGGGTGGCATGTCCAACGAGCTC
AACAATATCATCTCTCGAACCACAGATGGCGTCTACGAGGGCGTGGCCATTGGTGGGGAC
AGGTACCCCGGCTCAACGTTTATGGATCACGTGTTACGTTATCAGGACACTGCAGGAGTC
AAAATGATTGTGGTTCTTGGAGAGATAGGGGGCACAGAGGAGTATAAGATCTGCCGGGGC
GTCACGGAGGGCCGCATCACCAAGCCCGTGGTCTGCTGGTGCATCGGGACCTGTGCGGCC
ATGTTCTCCTCCGAGGTCCAGTTCGGCCACGCTGGAGCTTGTGCCAACCAGGCTTCTGAA
ACCGCAGTTGCCAAGAACCAGGCCTTGAAGGAGGCTGGAGTGTTTGTGCCCCGGAGCTTC
GATGAGCTTGGAGAAATCATCCAGTCCGTGTACGAGGATCTCGTGGCCAGAGGAGTCATT
GTGCCTGCTCAGGAGGTTCCGCCCCCCACAGTACCCATGGACTACTCTTGGGCCCGGGAA
TTGGGCTTGATCCGCAAACCTGCCTCGTTCATGACCAGCATCTGTGACGAGCGAGGACAG
GAGCTCATCTACGCGGGCATGCCCATCACTGAGGTCTTCAAGGAGGAGATGGGCATTGGC
GGGGTCCTCGGCCTCCTCTGGTTCCAGAAAAGGTTGCCCAAATACTCCTGCCAGTTCATT
GAGATGTGCCTGATGGTGACGGCTGATCACGGGCCTGCCGTCTCTGGGGCTCATAACACC
ATCATCTGCGCTCGAGCCGGCAAGGACCTCGTCTCCAGCCTCACCTCGGGACTGCTTACC
ATTGGCGACCGGTTTGGGGGTGCCCTGGATGCAGCAGCCAAGATGTTCAGCAAGGCCTTT
GACAGTGGTATCATCCCCATGGAGTTTGTGAACAAGATGAAGAAGGAAGGAAAGCTTATC
ATGGGCATTGGTCACCGAGTGAAGTCGATCAACAACCCAGACATGCGCGTGCAGATTCTC
AAAGATTATGTCAGACAACACTTCCCTGCCACCCCACTGCTCGACTACGCACTGGAAGTA
GAGAAGATTACCACTTCCAAGAAACCAAACCTTATCCTGAATGTGGACGGTTTAATCGGA
GTTGCATTTGTAGACATGCTTAGACACTGCGGGTCCTTCACTCGGGAGGAAGCTGATGAA
TATATTGACATTGGAGCCCTCAACGGCATCTTTGTGCTGGGAAGGAGCATGGGCTTCATT
GGACACTATCTTGATCAGAAGAGGCTGAAGCAGGGGCTCTACCGTCACCCATGGGATGAT
ATTTCATATGTTCTTCCGGAACACATGAGCATGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 1091 |
| Molecular Weight
| 119789.0 |
| Theoretical pI
| 7.25 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>ATP-citrate synthase
MSAKAISEQTGKELLYKYICTTSAIQNRFKYARVTPDTDWARLLQDHPWLLSQSLVVKPD
QLIKRRGKLGLIGVNLTLDGVKSWLKPRLGQEATVGKATGFLKNFLIEPFVPHTQEEEFY
VCIYATREGDYVLFHHEGGVDVGDVDAKAQKLLVGVDEKLNPEDIKKHLLVHAPEDKKEI
LASFISGLFNFYEDLYFTYLEINPLVVTKDGVYVLDLAAKVDATADYICKVKWGDIEFPP
PFGREAYPEEAYIADLDAKSGASLKLTLLNPKGRIWTMVAGGGASVVYSDTICDLGGVNE
LANYGEYSGAPSEQQTYDYAKTILSLMTREKHPDGKILIIGGSIANFTNVAATFKGIVRA
IRDYQGPLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETHMTAIVGMALG
HRPIPNQPPTAAHTANFLLNASGSTSTPAPSRTASFSESRTDEVAPAKKAKPAMLQGKSA
TLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILI
PVFKNMADAMKKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLI
KKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNEL
NNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTAGVKMIVVLGEIGGTEEYKICRG
VTEGRITKPVVCWCIGTCAAMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSF
DELGEIIQSVYEDLVARGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQ
ELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNT
IICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLI
MGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGLIG
VAFVDMLRHCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLYRHPWDD
ISYVLPEHMSM
|
| External Links |
|---|
| GenBank ID Protein
| AAI08139.1 |
| UniProtKB/Swiss-Prot ID
| Q32PF2 |
| UniProtKB/Swiss-Prot Entry Name
| ACLY_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC108138 |
| GeneCard ID
| ACLY |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
