| Identification |
|---|
| BMDB Protein ID
| BMDBP00176 |
| Secondary Accession Numbers
| None |
| Name
| Fructose-1,6-bisphosphatase 1 |
| Synonyms
|
Not Available
|
| Gene Name
| FBP1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Carbohydrate transport and metabolism |
| Specific Function
| Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. |
| Pathways
|
- Carbohydrate biosynthesis
- Fructose and Mannose Degradation
- Gluconeogenesis
- Pentose Phosphate Pathway
|
| Reactions
|
| Fructose 1,6-bisphosphate + Water → Fructose 6-phosphate + Hydrogen phosphate |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| Not Available |
| SNPs
| FBP1 |
| Gene Sequence
|
>1017 bp
ATGACGGACCAGGCAGCCTTCGACACCAATATCGTCACCGTGACCCGCTTCGTCATGGAA
GAGGGCAGGAAGGCCCGTGGCACGGGCGAGATGACCCAACTGCTCAACTCGCTTTGCACC
GCGGTCAAAGCCATCTCCACGGCCGTGCGCAAGGCGGGCATCGCGCACCTCTATGGAATT
GCTGGCACTACCAATGTGACGGGAGATCAAGTGAAGAAGCTGGATGTCCTCTCCAATGAC
CTGGTTGTTAATGTGTTAAAGTCATCTTTTGCTACCTGTGTTCTTGTGTCAGAAGAAGAT
GAACATGCCATAATAGTAGAACCTGAGAAAAGGGGTAAATATGTGGTCTGTTTTGATCCC
CTTGATGGATCATCCAACATCGACTGCCTTGTGTCCATTGGAACCATCTTTGGCATCTAC
AAAAAGATTTCGAAAGATGACCCTTCTGAGAAGGACGCTCTGCAGCCAGGCCGGAACCTG
GTGGCTGCTGGCTATGCGCTCTATGGCAGTGCCACTATGTTGGTCCTGGCCATGGCGAAT
GGAGTCAACTGCTTCATGCTGGACCCGGCCATTGGAGAGTTCATTTTGGTGGACAGGGAT
GTGAAGATCAAAAAGAAAGGGAGCATCTATAGCCTCAATGAAGGCTATGCGAAGGACTTT
GATCCTGCCCTCACCGAGTATGTCCAGAGGAAGAAGTTCCCCCCAGACAACTCAGCCCCC
TATGGCGCCAGGTACGTGGGCTCCATGGTAGCCGATGTACACCGCACCCTAGTCTATGGA
GGGATCTTTATGTATCCAGCTAACAAGAAAAGCCCCAGTGGAAAGCTGAGACTACTGTAT
GAATGTAACCCCATGGCCTATGTCATAGAGAAGGCAGGAGGAATGGCTACCACCGGGAAG
GAAACTGTGCTGGACATTGTTCCCACTGACATCCATCAGAAGTCGCCCATCATCTTGGGG
TCTCCTGAAGATGTGACTGAGTTCCTGGAGATATACAAGAAGCATGCTGCCAAATGA
|
| Protein Properties |
|---|
| Number of Residues
| 338 |
| Molecular Weight
| 36728.0 |
| Theoretical pI
| 7.01 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Fructose-1,6-bisphosphatase 1
MTDQAAFDTNIVTVTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGI
AGTTNVTGDQVKKLDVLSNDLVVNVLKSSFATCVLVSEEDEHAIIVEPEKRGKYVVCFDP
LDGSSNIDCLVSIGTIFGIYKKISKDDPSEKDALQPGRNLVAAGYALYGSATMLVLAMAN
GVNCFMLDPAIGEFILVDRDVKIKKKGSIYSLNEGYAKDFDPALTEYVQRKKFPPDNSAP
YGARYVGSMVADVHRTLVYGGIFMYPANKKSPSGKLRLLYECNPMAYVIEKAGGMATTGK
ETVLDIVPTDIHQKSPIILGSPEDVTEFLEIYKKHAAK
|
| External Links |
|---|
| GenBank ID Protein
| AAI02975.1 |
| UniProtKB/Swiss-Prot ID
| Q3SZB7 |
| UniProtKB/Swiss-Prot Entry Name
| F16P1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC102974 |
| GeneCard ID
| FBP1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
