1.0 2018-05-07 22:21:13 UTC 2020-05-20 21:09:22 UTC BMDBP00186 Enzyme ILK Involved in ATP binding Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. BMDB0001341 ADP BMDB0001429 Phosphate 15 >1359 bp ATGGACGACATTTTCACTCAGTGCCGGGAGGGCAACGCGGTTGCGGTCCGCCTGTGGCTG GACAACACGGAGAACGACCTCAACCAGGGGGACGATCATGGCTTCTCCCCCTTGCACTGG GCCTGCCGAGAAGGCCGATCTGCTGTGGTTGAGATGCTGATCATGCGGGGGGCACGAATC AATGTGATGAACCGTGGGGATGATACCCCTCTGCACCTGGCAGCCAGTCATGGGCACCGT GATATTGTACAGAAGCTGCTGCAGTACAAAGCTGACATCAATGCGGTGAATGAGCATGGG AATGTGCCCCTGCACTATGCCTGTTTCTGGGGCCAAGATCAGGTGGCAGAGGACCTCGTG GCAAATGGGGCCCTTGTCAGCATCTGTAACAAGTATGGAGAGATGCCTGTGGACAAAGCT AAGCCACCCCTGAGAGAGCTGCTCCGAGAGCGGGCAGAGAAGATGGGCCAGAATCTGAAC CGTATACCATACAAGGACACATTCTGGAAGGGGACTACCCGCACTCGGCCCCGAAATGGG ACTCTGAACAAACACTCCGGCATTGACTTCAAACAGCTCAACTTCCTGGCGAAGCTCAAC GAGAATCACTCTGGAGAGCTATGGAAGGGCCGCTGGCAGGGCAATGACATTGTCGTGAAG ATGCTAAAGGTTCGAGACTGGAGTACAAGGAAGAGCAGAGACTTCAATGAGGAGTGTCCC CGGCTCAGGATTTTCTCACATCCCAATGTGCTCCCAGTGCTTGGTGCCTGTCAGTCTCCA CCTGCTCCTCACCCCACCCTCATCACACACTGGATGCCATACGGATCCCTGTACAATGTG CTACATGAAGGCACCAATTTTGTTGTGGACCAGAGCCAGGCTGTGAAGTTTGCATTGGAC ATGGCAAGGGGCATGGCCTTCCTACACACACTAGAGCCCCTCATCCCACGACATGCACTC AACAGCCGTAGTGTAATGATTGATGAGGACATGACTGCTCGAATCAGTATGGCCGACGTC AAGTTCTCCTTCCAGTGCCCCGGGCGCATGTATGCACCTGCCTGGGTGGCTCCTGAAGCT CTGCAAAAGAAGCCTGAAGACACAAACAGACGCTCAGCAGATATGTGGAGTTTTGCAGTG CTTCTATGGGAACTGGTGACACGGGAGGTACCCTTTGCTGACCTCTCCAACATGGAAATT GGAATGAAGGTGGCACTGGAAGGCCTTCGGCCTACCATCCCACCAGGCATTTCCCCCCAC GTATGTAAACTCATGAAGATCTGCATGAATGAAGACCCTGCTAAGCGACCCAAGTTTGAC ATGATCGTGCCTATCCTGGAGAAGATGCAGGACAAGTAG 452 51447.0 8.18 None >Integrin-linked protein kinase MDDIFTQCREGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARI NVMNRGDDTPLHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLV ANGALVSICNKYGEMPVDKAKPPLRELLRERAEKMGQNLNRIPYKDTFWKGTTRTRPRNG TLNKHSGIDFKQLNFLAKLNENHSGELWKGRWQGNDIVVKMLKVRDWSTRKSRDFNEECP RLRIFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALD MARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQCPGRMYAPAWVAPEA LQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPH VCKLMKICMNEDPAKRPKFDMIVPILEKMQDK AAI04604.1 Q3SWY2 ILK_BOVIN BC104603 ILK