| Identification |
|---|
| BMDB Protein ID
| BMDBP00202 |
| Secondary Accession Numbers
| None |
| Name
| Beta-adrenergic receptor kinase 1 |
| Synonyms
|
Not Available
|
| Gene Name
| GRK2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (By similarity). Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (PubMed:21659505). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 29 |
| Locus
| Not Available |
| SNPs
| GRK2 |
| Gene Sequence
|
>2070 bp
ATGGCGGACCTGGAGGCGGTGCTGGCCGACGTGAGCTACCTGATGGCCATGGAGAAGAGC
AAGGCCACGCCGGCGGCGCGCGCCAGCAAGAAGATCCTGCTGCCCGAGCCCAGCATCCGC
AGCGTCATGCAGAAGTACCTGGAGGACCGGGGCGAGGTGACTTTTGAGAAGATCTTCTCC
CAGAAGCTGGGGTACCTGCTTTTCCGAGACTTCTGCCTGAAGCACCTGGAGGAGGCCAAG
CCCTTGGTAGAGTTCTACGAGGAGATCAAGAAATACGAGAAGCTGGAGACAGAGGAGGAG
CGCCTGGTCTGCAGCCGAGAGATCTTCGACACGTACATCATGAAGGAGCTGCTGGCCTGC
TCACATCCTTTCTCGAAGAGCGCCATTGAGCACGTCCAGGGCCATCTGGTGAAGAAGCAG
GTGCCTCCGGATCTCTTCCAGCCATATATTGAAGAAATTTGCCAGAACCTCCGAGGAGAC
GTGTTCCAGAAATTCATCGAGAGCGATAAATTCACACGATTTTGCCAGTGGAAGAATGTA
GAGCTCAACATCCACCTGACCATGAACGACTTCAGTGTGCACCGCATCATCGGGCGAGGC
GGCTTCGGTGAGGTCTACGGCTGCCGGAAGGCCGACACGGGCAAGATGTACGCCATGAAG
TGTCTGGACAAGAAGCGCATCAAGATGAAGCAAGGGGAGACTCTGGCCCTGAATGAGCGC
ATCATGCTGTCGCTCGTCAGCACCGGGGACTGCCCGTTCATCGTCTGCATGTCATACGCC
TTCCACACACCGGACAAGCTCAGCTTCATCCTGGATCTCATGAACGGCGGGGACCTGCAC
TACCACCTGTCCCAGCACGGGGTCTTCTCCGAGGCCGACATGCGTTTCTACGCCGCCGAG
ATCATCCTGGGCCTGGAGCACATGCACAACCGCTTCGTGGTCTACCGGGACCTGAAGCCG
GCCAACATCCTGCTGGACGAGCACGGCCACGTGCGCATCTCAGACCTGGGCCTGGCCTGT
GACTTCTCCAAGAAGAAGCCTCACGCCAGTGTGGGCACCCACGGGTACATGGCTCCCGAG
GTTCTACAGAAGGGTGTGGCCTACGACAGCAGCGCCGACTGGTTCTCCCTGGGCTGCATG
CTCTTCAAGCTGCTGCGAGGGCATAGCCCTTTCCGGCAGCACAAGACCAAAGACAAGCAT
GAGATCGACAGAATGACATTGACAATGGCTGTGGAGCTGCCTGACTCCTTCTCCCCTGAG
CTCCGCTCCTTGCTGGAGGGGCTGCTGCAGAGGGATGTCAACCGGAGGCTAGGCTGCCTG
GGCCGAGGGGCCCAGGAGGTGAAGGAGAGCCCCTTCTTCCGTTCCCTGGACTGGCAGATG
GTCTTTTTACAAAAGTACCCTCCCCCGTTGATCCCCCCACGAGGGGAGGTGAATGCAGCC
GACGCCTTTGACATTGGCTCCTTCGATGAGGAGGACACAAAAGGAATCAAGCTACTGGAC
AGTGACCAGGAGCTCTACCGCAACTTCCCCCTGACCATCTCGGAGCGGTGGCAGCAGGAG
GTAGCAGAGACTGTCTTTGACACCATCAATGCTGAGACGGACCGGCTGGAGGCCCGCAAG
AAAACCAAAAACAAGCAGTTGGGCCACGAGGAAGACTACGCCCTGGGCAAGGACTGCATC
ATGCATGGCTACATGTCCAAGATGGGCAACCCCTTCCTGACCCAGTGGCAGCGGCGGTAC
TTCTACCTGTTCCCTAACCGGCTCGAGTGGCGGGGCGAGGGCGAGGCCCCGCAGAGCCTG
CTGACCATGGAGGAGATCCAGTCGGTGGAGGAGACGCAGATCAAGGAGCGAAAGTGCCTC
CTCCTCAAGATCCGAGGTGGCAAGCAGTTTGTCCTGCAGTGCGATAGTGACCCAGAGCTG
GTGCAGTGGAAGAAGGAGCTTCGAGACGCCTACCGCGAGGCCCAGCAGCTAGTGCAGCGG
GTGCCCAAGATGAAGAACAAGCCGCGCTCGCCCGTCGTGGAGCTGAGCAAGGTGCCACTG
ATCCAGCGCGGCAGTGCCAACGGCCTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 689 |
| Molecular Weight
| 79647.0 |
| Theoretical pI
| 7.29 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 66-86
- 93-115
- 298-319
- 345-366
- 843-863
- 876-895
- 926-947
- 962-984
- 991-1011
- 1030-1055
|
| Protein Sequence
|
>Beta-adrenergic receptor kinase 1
MADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFS
QKLGYLLFRDFCLKHLEEAKPLVEFYEEIKKYEKLETEEERLVCSREIFDTYIMKELLAC
SHPFSKSAIEHVQGHLVKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNV
ELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER
IMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAE
IILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPE
VLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPE
LRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAA
DAFDIGSFDEEDTKGIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARK
KTKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSL
LTMEEIQSVEETQIKERKCLLLKIRGGKQFVLQCDSDPELVQWKKELRDAYREAQQLVQR
VPKMKNKPRSPVVELSKVPLIQRGSANGL
|
| External Links |
|---|
| GenBank ID Protein
| AAA30384.1 |
| UniProtKB/Swiss-Prot ID
| P21146 |
| UniProtKB/Swiss-Prot Entry Name
| ARBK1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| M34019 |
| GeneCard ID
| GRK2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
