| Identification |
|---|
| BMDB Protein ID
| BMDBP00206 |
| Secondary Accession Numbers
| None |
| Name
| Dual specificity protein phosphatase 6 |
| Synonyms
|
Not Available
|
| Gene Name
| DUSP6 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Signal transduction mechanisms |
| Specific Function
| Inactivates MAP kinases. Has a specificity for the ERK family. Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia. Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain. |
| Pathways
|
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| Not Available |
| SNPs
| DUSP6 |
| Gene Sequence
|
>1146 bp
ATGATAGATACGCTCAGACCCGTGCCCTTCGCGTCGGAAATGGCGATCAGCAAGACGGTG
GCGTGGCTCAACGAGCAGCTGGAGCTGGGCAACGAGCGGCTGCTGTTGATGGACTGCCGG
CCGCAGGAGCTGTACGAGTCGTCCCACATCGAGTCCGCCATCAACGTGGCCATTCCAGGG
ATCATGCTGCGGCGCCTGCAGAAGGGCAGCCTGCCGGTGCGCGCGCTATTCACGCGCGGC
GAGGACCGGGACCGCTTCACCCGGCGCTGCGGCACCGATACCGTGGTGCTCTACGATGAG
AGCAGCAGCGACTGGAACGAGAATACGGGCGGCGAGTCGGTGCTCGGGCTGCTGCTCAAG
AAGCTCAAGGACGAGGGATGCCGGGCGTTCTACCTGGAAGGTGGTTTCAGTAAGTTCCAA
GCCGAGTTCGCCCTGCACTGCGAGACCAATCTAGACGGCTCGTGTAGCAGCAGCTCGCCA
CCGTTGCCAGTGCTGGGGCTCGGGGGCCTGCGGATCAGCTCCGACTCCTCCTCGGACATT
GAGTCTGACCTTGACCGAGACCCCAATAGTGCAACGGACTCGGATGGCAGCCCGCTGTCC
AACAGTCAGCCTTCTTTCCCTGTGGAGATCTTGCCCTTCCTCTATTTGGGCTGTGCCAAG
GACTCCACCAACCTGGACGTGTTGGAGGAGTTTGGCATCAAGTACATATTGAACGTCACC
CCCAACTTGCCGAATCTCTTTGAGAATGCAGGAGAGTTCAAATACAAGCAGATCCCCATC
TCGGATCACTGGAGCCAAAACCTGTCCCAGTTTTTCCCTGAGGCCATTTCTTTCATAGAT
GAAGCCCGGGGCAAAAACTGTGGCGTCCTGGTGCATTGCTTAGCTGGCATCAGCCGCTCG
GTCACTGTGACTGTGGCTTACCTTATGCAGAAGCTCAATCTGTCGATGAACGATGCTTAT
GACATTGTGAAGATGAAGAAATCCAACATCTCCCCCAACTTCAACTTCATGGGCCAGCTG
CTGGACTTCGAGAGGACGCTGGGACTGAGCAGCCCCTGTGACAACCGCGTCCCCACACAG
CAGCTCTATTTCACCACCCCCTCCAACCAGAATGTCTACCAGGTGGACTCTCTGCAATCC
ACGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 381 |
| Molecular Weight
| 42307.0 |
| Theoretical pI
| 4.5 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Dual specificity protein phosphatase 6
MIDTLRPVPFASEMAISKTVAWLNEQLELGNERLLLMDCRPQELYESSHIESAINVAIPG
IMLRRLQKGSLPVRALFTRGEDRDRFTRRCGTDTVVLYDESSSDWNENTGGESVLGLLLK
KLKDEGCRAFYLEGGFSKFQAEFALHCETNLDGSCSSSSPPLPVLGLGGLRISSDSSSDI
ESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVT
PNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRS
VTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNRVPTQ
QLYFTTPSNQNVYQVDSLQST
|
| External Links |
|---|
| GenBank ID Protein
| ABF57380.1 |
| UniProtKB/Swiss-Prot ID
| Q2KJ36 |
| UniProtKB/Swiss-Prot Entry Name
| DUS6_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BT025424 |
| GeneCard ID
| DUSP6 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
