| Identification |
|---|
| BMDB Protein ID
| BMDBP00233 |
| Secondary Accession Numbers
| None |
| Name
| Disintegrin and metalloproteinase domain-containing protein 10 |
| Synonyms
|
Not Available
|
| Gene Name
| ADAM10 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in metalloendopeptidase activity |
| Specific Function
| Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) (PubMed:10097139). Contributes to the normal cleavage of the cellular prion protein (By similarity). Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (By similarity). Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form (By similarity). Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (By similarity). Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Enhances the cleavage of CHL1 by BACE1 (By similarity). Cleaves NRCAM (By similarity). Cleaves TREM2, resulting in shedding of the TREM2 ectodomain (By similarity). Involved in the development and maturation of glomerular and coronary vasculature (By similarity). During development of the cochlear organ of Corti, promotes pillar cell separation by forming a ternary complex with CADH1 and EPHA4 and cleaving CADH1 at adherens junctions (By similarity). May regulate the EFNA5-EPHA3 signaling (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| Not Available |
| SNPs
| ADAM10 |
| Gene Sequence
|
>2247 bp
ATGGTGTTGCTGAGAGTGTTAATTCTGCTCCTCTCCTGGGTTGCGGGGCTGGGAGGTCAG
TATGGAAATCCTTTAAATAAATACATTAGACATTATGAAGGATTATCATATGATGTGGAT
TCATTACACCAAAAACACCAGCGTGCCAAAAGAGCAGTATCACATGAGGACCAGTTTTTA
CGGCTAGATTTTCATGCTCATGGAAGACATTTCAACCTTCGAATGAAGAGGGATACTTCC
CTTTTCAGTGAGGAGTTTAGGGTGGAAACATCAAATGCAGTACTGGATTATGATACTTCT
CATATTTACACTGGACATATTTATGGTGAAGAAGGAAGTTTTAGCCATGGGTCTGTTATT
GATGGAAGATTTGAAGGATTCATTCAGACTCATGGTGGCACATTTTATGTTGAACCAGCA
GAGAGATATATTAAAGACCGAACTCTGCCATTTCACTCTGTCATTTATCATGAAGATGAT
ATTAAGTATCCCCATAAATATGGTCCACAGGGGGGTTGTGCAGATCATTCAGTGTTTGAA
AGAATGAGGAAGTACCAGATGACTGGTGTAGAAGAAGTAACACAGACACCTCAAGAAAAA
CATGCTATTAATGGTCCAGAACTCCTGAGGAAAAAACGTACAACTGTAGCTGAAAAAAAT
ACCTGTCAGCTTTATATTCAGACCGATCATCTGTTCTTTAAATATTACGGAACACGAGAA
GCTGTGATTGCCCAGATATCCAGTCATGTTAAAGCAATTGACACAATTTACCAGACAACA
GACTTCTCTGGAATCCGTAACATCAGTTTCATGGTGAAACGCATAAGAATCAACACAACT
GCTGATGAGAAGGACCCTACAAATCCATTCCGTTTTCCAAATATTGGTGTGGAGAAGTTT
CTGGAGCTGAATTCTGAGCAGAATCATGATGACTACTGTTTGGCCTACGTTTTCACAGAT
CGAGATTTTGATGATGGTGTCCTTGGTCTGGCGTGGGTTGGAGCACCTTCAGGAAGCTCT
GGAGGAATATGTGAAAAAAGTAAGCTCTATTCAGATGGTAAGAAGAAGTCTTTAAACACT
GGAATTATTACTGTTCAGAACTATGGGTCTCACGTACCCCCCAAAGTCTCTCACATTACG
TTTGCTCATGAAGTTGGACATAACTTTGGATCTCCGCATGATTCTGGAACAGAGTGCACT
CCAGGAGAATCTAAGAATTTAGGACAAAAAGAAAATGGCAACTACATCATGTATGCAAGA
GCAACATCTGGGGACAAACTTAACAACAATAAATTCTCACTCTGTAGTATTAGAAATATA
AGTCAAGTTCTTGAGAAGAAGAGAAACAACTGTTTTGTTGAATCTGGCCAACCTATTTGT
GGAAATGGGATGGTAGAACAAGGTGAAGAATGTGATTGTGGTTATAGTGACCAGTGTAAA
GACGAGTGCTGCTACGATGCAAATCAGCCGGAGGGGAAAAAATGCAAGCTGAAACCTGGA
AAGCAGTGCAGTCCAAGTCAAGGTCCCTGTTGTACAGCACATTGTGCATTCAAGTCAAAA
ACTGAAAAGTGTCGGGATGATTCAGACTGTGCAAAAGAAGGAATATGTAATGGCATCACA
GCTCTCTGCCCAGCCTCTGATCCTAAACCGAACTTCACAGACTGTAATAGACATACGCAA
GTGTGCATTAATGGGCAATGTGCAGGTTCTATCTGTGAGAAACATGGCTTGGAGGAGTGT
ACCTGTGCCAGTTCTGATGGCAAAGATGATAAGGAATTATGCCATGTCTGCTGTATGAAG
AAGATGGAGCCATCAACTTGTGCCAGTACAGGGTCTGTGCAGTGGAACAAGTACTTCCTT
GGTCGAACTATCACCCTGCAACCTGGATCCCCATGCAATGATTTTAGAGGCTACTGTGAT
GTTTTCATGCGGTGCAGATTAGTAGATGCTGATGGTCCTCTAGCGAGGCTTAAAAAAGCA
ATTTTCAGTCCAGAGCTCTATGAAAACATAGCTGAATGGATTGTGGCTTACTGGTGGGCA
GTATTACTTATGGGAATTGCCCTGATCATGTTAATGGCTGGTTTTATTAAGATATGCAGT
GTACACACTCCAAGTAGTAATCCAAAGTTGCCTCCTCCTAAACCTCTTCCAGGCACTTTA
AAGAGGAGAAGACCTCCCCAGCCCATTCAACAGCCCCAGCGTCAGAGGCCCCGGGAGAGT
TATCAGATGGGACACATGAGACGTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 748 |
| Molecular Weight
| 84188.0 |
| Theoretical pI
| 7.81 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Disintegrin and metalloproteinase domain-containing protein 10
MVLLRVLILLLSWVAGLGGQYGNPLNKYIRHYEGLSYDVDSLHQKHQRAKRAVSHEDQFL
RLDFHAHGRHFNLRMKRDTSLFSEEFRVETSNAVLDYDTSHIYTGHIYGEEGSFSHGSVI
DGRFEGFIQTHGGTFYVEPAERYIKDRTLPFHSVIYHEDDIKYPHKYGPQGGCADHSVFE
RMRKYQMTGVEEVTQTPQEKHAINGPELLRKKRTTVAEKNTCQLYIQTDHLFFKYYGTRE
AVIAQISSHVKAIDTIYQTTDFSGIRNISFMVKRIRINTTADEKDPTNPFRFPNIGVEKF
LELNSEQNHDDYCLAYVFTDRDFDDGVLGLAWVGAPSGSSGGICEKSKLYSDGKKKSLNT
GIITVQNYGSHVPPKVSHITFAHEVGHNFGSPHDSGTECTPGESKNLGQKENGNYIMYAR
ATSGDKLNNNKFSLCSIRNISQVLEKKRNNCFVESGQPICGNGMVEQGEECDCGYSDQCK
DECCYDANQPEGKKCKLKPGKQCSPSQGPCCTAHCAFKSKTEKCRDDSDCAKEGICNGIT
ALCPASDPKPNFTDCNRHTQVCINGQCAGSICEKHGLEECTCASSDGKDDKELCHVCCMK
KMEPSTCASTGSVQWNKYFLGRTITLQPGSPCNDFRGYCDVFMRCRLVDADGPLARLKKA
IFSPELYENIAEWIVAYWWAVLLMGIALIMLMAGFIKICSVHTPSSNPKLPPPKPLPGTL
KRRRPPQPIQQPQRQRPRESYQMGHMRR
|
| External Links |
|---|
| GenBank ID Protein
| CAA79973.1 |
| UniProtKB/Swiss-Prot ID
| Q10741 |
| UniProtKB/Swiss-Prot Entry Name
| ADA10_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| Z21961 |
| GeneCard ID
| ADAM10 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
