| Identification |
|---|
| BMDB Protein ID
| BMDBP00234 |
| Secondary Accession Numbers
| |
| Name
| Tissue-type plasminogen activator |
| Synonyms
|
Not Available
|
| Gene Name
| PLAT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in serine-type endopeptidase activity |
| Specific Function
| Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. |
| Pathways
|
Not Available
|
| Reactions
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 27 |
| Locus
| Not Available |
| SNPs
| PLAT |
| Gene Sequence
|
>1701 bp
ATGATGAGCGCAATGAAGACAGAGTTCCTGTGCGTGCTGCTGCTCTGTGGAGCTGTCTTC
ACGTCGCCCAGCCAGGAAACCTACAGACGACTCAGGAGAGGCGCCAGATCGTACAAAGTG
ACCTGCAGAGATGGAAAAACGCAGATGACGTACCGCCAACACGACTCCTGGCTGCGACCC
CTGCTCAGGGGCAACCAAGTGGAGCACTGCTGGTGCGACGGCGGCCGGGCCCAGTGCCAC
TCGGTGCCCGTCAGAAGTTGCAGTGAACCTTGGTGTTTCAATGGGGGGACATGTCGGCAG
GCCCTCTATTCTTCAGACTTTGTCTGCCAGTGCCCAGAAGGGTTCATGGGGAAGCTCTGT
GAAATAGATGCTACCGCCACGTGCTATAAGGACCAGGGTGTCGCCTACAGAGGCACGTGG
AGCACGGCAGAGAGCGGGGCTGAGTGCGCCAATTGGAACAGCAGCGGCCTGGCCATGAAG
CCGTACAGCGGGCGCAGGCCCAACGCCATCAGGCTGGGCCTTGGGAACCACAACTACTGC
AGAAACCCGGACCAAGACTCAAAGCCCTGGTGCTACGTCTTCAAGGCAGGGAAATACATC
TCTGAGTTCTGCAGCACTCCAGCCTGCGCTAAGGTTGCAGAAGAAGATGGGGACTGCTAC
ACTGGAAACGGGCTGGCGTACCGCGGCACCCGCAGCCACACCAAGTCTGGGGCTTCCTGC
CTCCCGTGGAATTCCGTGTTCCTAACCAGCAAGATTTACACCGCCTGGAAGAGCAACGCG
CCGGCCCTGGGCCTGGGGAAGCACAACCACTGCAGGAATCCCGATGGGGACGCCCAGCCT
TGGTGCCACGTGTGGAAGGACCGCCAGCTGACCTGGGAGTACTGTGATGTGCCCCAGTGC
GTCACCTGTGGCCTGAGACAGTACAAGCGGCCCCAGTTCCGCATCAAAGGAGGCCTCTTC
GCGGACATCACCTCCCACCCCTGGCAGGCCGCGATCTTCGTCAAGAACAGGCGGTCCCCG
GGAGAGCGGTTTCTGTGTGGGGGGATCCTGATCAGCTCCTGCTGGGTGCTGTCGGCCGCC
CACTGCTTCCAGGAGAGGTACCCGCCTCACCATCTCAAGGTGTTCCTGGGCAGGACGTAC
CGGCTGGTCCCTGGAGAGGAGGAGCAGACGTTTGAAGTAGAAAAATACATCATCCACAAG
GAATTTGATGATGACACTTATGACAATGACATCGCGCTGCTGCACCTGAAATCAGACTCG
CTGACCTGCGCCCGGGAGAGTGCCTCTGTCCGCACCATCTGCCTCCCAGACGCCAGCCTG
CAGCTGCCCGACTGGACGGAGTGCGAGCTGTCCGGCTACGGGAAACACGAGTCCTCTTCT
CCGTTCTTTTCCGAGCGGCTGAAGGAGGCTCACGTCAGGTTGTACCCATCCAGCCGCTGC
ACTTCCCAACACTTGTTTAACAGGACCGTCACCAACAACATGCTGTGTGCCGGAGACACA
CGGAGCGGTGGGGACCACACAAACCTGCACGATGCCTGCCAGGGTGACTCGGGCGGCCCC
CTGGTGTGTATGAAGGACAACCACATGACCTTGGTCGGCATCATCAGCTGGGGCCTGGGC
TGCGGGCGGAAGGACGTCCCGGGCGTGTACACCAAGGTGACTAACTACCTGGACTGGATC
CGAGACAACACTCGCCCATGA
|
| Protein Properties |
|---|
| Number of Residues
| 566 |
| Molecular Weight
| 63701.0 |
| Theoretical pI
| 8.09 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Tissue-type plasminogen activator
MMSAMKTEFLCVLLLCGAVFTSPSQETYRRLRRGARSYKVTCRDGKTQMTYRQHDSWLRP
LLRGNQVEHCWCDGGRAQCHSVPVRSCSEPWCFNGGTCRQALYSSDFVCQCPEGFMGKLC
EIDATATCYKDQGVAYRGTWSTAESGAECANWNSSGLAMKPYSGRRPNAIRLGLGNHNYC
RNPDQDSKPWCYVFKAGKYISEFCSTPACAKVAEEDGDCYTGNGLAYRGTRSHTKSGASC
LPWNSVFLTSKIYTAWKSNAPALGLGKHNHCRNPDGDAQPWCHVWKDRQLTWEYCDVPQC
VTCGLRQYKRPQFRIKGGLFADITSHPWQAAIFVKNRRSPGERFLCGGILISSCWVLSAA
HCFQERYPPHHLKVFLGRTYRLVPGEEEQTFEVEKYIIHKEFDDDTYDNDIALLHLKSDS
LTCARESASVRTICLPDASLQLPDWTECELSGYGKHESSSPFFSERLKEAHVRLYPSSRC
TSQHLFNRTVTNNMLCAGDTRSGGDHTNLHDACQGDSGGPLVCMKDNHMTLVGIISWGLG
CGRKDVPGVYTKVTNYLDWIRDNTRP
|
| External Links |
|---|
| GenBank ID Protein
| CAA59795.1 |
| UniProtKB/Swiss-Prot ID
| Q28198 |
| UniProtKB/Swiss-Prot Entry Name
| TPA_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| X85800 |
| GeneCard ID
| PLAT |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
