| Identification |
|---|
| BMDB Protein ID
| BMDBP00250 |
| Secondary Accession Numbers
| None |
| Name
| Palmitoyltransferase ZDHHC20 |
| Synonyms
|
Not Available
|
| Gene Name
| ZDHHC20 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in acyltransferase activity |
| Specific Function
| Catalyzes palmitoylation of Cys residues on target proteins. Catalyzes palmitoylation of Cys residues in the cytoplasmic C-terminus of EGFR, and modulates the duration of EGFR signaling by modulating palmitoylation-dependent EGFR internalization and degradation. Has a preference for acyl-CoA with C16 fatty acid chains. Can also utilize acyl-CoA with C14 and C18 fatty acid chains. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 12 |
| Locus
| Not Available |
| SNPs
| ZDHHC20 |
| Gene Sequence
|
>1098 bp
ATGGCGCCCTGTACGCTCTGGCGCTGCTGCCAGCGCACCGTGGGCTGGGTGCCTGTGTTG
TTCATCACCTTCGTTGTCGTGTGGTCCTACTACGCGTACGTGGTGGAGCTGTGCGTGTTT
ACACTTTCTGGAAATGGAGAAAACGGAAAGGCCGTTGTTTACCTTGTGGCTTTCCATCTG
TTCTTTGTTATGTTTGTATGGTCCTATTGGATGACAATTTTCACATCTCCCGCTTCCCCC
TCCAAAGAGTTCTGCTTGTCCAATTCTGAGAAGGAACGTTATGAAAAGGAATTCAGCCAA
GAAAGACAACAAGAAATTTTGAGAAGAGCAGCAAGGGACTTACCTATCTACACCACATCG
GCTTCAAAGACCGTCAGATATTGTGAAAGATGTCAGCTGATTAAGCCGGACCGTGCGCAT
CACTGCTCAGCATGTGACATGTGTATTCTTAAGATGGACCATCACTGTCCTTGGGTGAAT
AACTGTGTGGGATTTTCTAATTACAAATTCTTCCTGCTCTTTTTATTCTACTCTCTGTTA
TATTGCCTTTTCGTGGCTACAACAGTTTTACAGTACTTCATAAAATTTTGGACGAATGAA
CTCACAGATACACGTGCAAAATTCCACGTACTTTTTCTTTTCTTTGTGTCTACGATGTTC
TTCATCAGCGTATTGTCACTTCTTAGCTACCACTGCTGGCTAGTTGGAAAAAACAGAACA
ACCATAGAATCATTCCGTGCACCCATGTTTTCATATGGAACTGATGGAAATGGTTTCTCA
CTTGGATGCAGTAAAAACTGGAGGCAAGTCTTTGGCGATGAAAAGAAATATTGGCTGCTT
CCAGTATTTTCAAGCCAGGGTGACGGCTGCAGTTTTCCGACTCGCCTTGTGGGGACGGAT
CCAGAGCAAGCTTCTGTCTCAAACCAAAGTGAAAGTGCCAGAAGTATTGGCTCAAATCAG
CCCTTTCCTATCAAACCGCTTAGTGAATCAAAAAACCGCCTGTTGGACAGTGACCCTCAG
TGGCTGGAGAGTGGATCTGAAGAAGGTGTTGGCGGATCAGGGACAAATAACCATGTAACA
GTGGCAATAGAAAACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 365 |
| Molecular Weight
| 41907.0 |
| Theoretical pI
| 7.72 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 15-35
- 54-74
- 170-190
- 208-231
|
| Protein Sequence
|
>Probable palmitoyltransferase ZDHHC20
MAPCTLWRCCQRTVGWVPVLFITFVVVWSYYAYVVELCVFTLSGNGENGKAVVYLVAFHL
FFVMFVWSYWMTIFTSPASPSKEFCLSNSEKERYEKEFSQERQQEILRRAARDLPIYTTS
ASKTVRYCERCQLIKPDRAHHCSACDMCILKMDHHCPWVNNCVGFSNYKFFLLFLFYSLL
YCLFVATTVLQYFIKFWTNELTDTRAKFHVLFLFFVSTMFFISVLSLLSYHCWLVGKNRT
TIESFRAPMFSYGTDGNGFSLGCSKNWRQVFGDEKKYWLLPVFSSQGDGCSFPTRLVGTD
PEQASVSNQSESARSIGSNQPFPIKPLSESKNRLLDSDPQWLESGSEEGVGGSGTNNHVT
VAIEN
|
| External Links |
|---|
| GenBank ID Protein
| AAI20295.1 |
| UniProtKB/Swiss-Prot ID
| Q0VC89 |
| UniProtKB/Swiss-Prot Entry Name
| ZDH20_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC120294 |
| GeneCard ID
| ZDHHC20 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
