| Identification |
|---|
| BMDB Protein ID
| BMDBP00305 |
| Secondary Accession Numbers
| None |
| Name
| NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| NDUFS1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 2 |
| Locus
| Not Available |
| SNPs
| NDUFS1 |
| Gene Sequence
|
>2184 bp
OFHAEIIISITE.AGGGAGAAGTATGTTAAGGATACCTGTAAGAAAGGCCTTAGTAGGCC
TTTCCAAGTCTTCTAAAGGATGTGTTCGAACAACTGCCACAGCAGCAAGCAACTTGATTG
AAGTATTTGTTGATGGTCAGTCTGTCATGGTGGAACCAGGAACTACCGTCCTTCAAGCTT
GTGAGAAGGTTGGCATGCAGATTCCTCGATTCTGTTATCACGAAAGGTTGTCTGTTGCTG
GAAACTGCAGGATGTGCCTTGTTGAAATTGAGAAAGCTCCTAAGGTTGTAGCTGCTTGTG
CCATGCCAGTAATGAAAGGTTGGAATATCCTGACAAACTCTGAGAAAACTAAGAAAGCCA
GAGAAGGTGTGATGGAGTTCTTATTAGCAAATCACCCACTGGACTGTCCTATTTGTGACC
AGGGAGGTGAATGTGATCTGCAGGACCAGTCCATGATGTTTGGAAGTGATAGGAGCCGGT
TTTTAGAGGGGAAACGTGCTGTGGAGGACAAGAACATTGGGCCGTTGGTAAAAACCATTA
TGACTAGGTGTATACAGTGTACTCGCTGCATCAGGTTTGCAAGTGAGATCGCAGGAGTGG
ATGATTTGGGAACTACAGGCAGAGGAAACGATATGCAAGTTGGCACATACATTGAAAAGA
TGTTCATGTCTGAACTTTCTGGCAATATCATTGACATCTGCCCTGTAGGTGCCCTGACTT
CTAAGCCCTATGCCTTTACCGCTCGGCCTTGGGAAACAAGAAAGACAGAATCCATTGATG
TAATGGATGCAGTTGGAAGTAATATTGTGGTCAGCACAAGAACTGGAGAGGTAATGAGGA
TTTTGCCAAGGATGCATGAGGACATCAATGAAGAGTGGATCTCTGATAAAACCAGATTTG
CCTATGATGGGCTAAAACGTCAAAGACTTACCGAACCGATGGTCAGAAATGAAAAGGGAC
TTTTAACACATACCACCTGGGAGGATGCACTCTCTCGTGTAGCTGGAATGTTGCAGAGCT
TTCAAGGCAATGATGTGGCAGCAATTGCAGGTGGCTTGGTGGATGCTGAAGCCCTCATAG
CTCTCAAAGATTTACTTAATAGAGTGGATTCTGACACGCTGTGCACTGAAGAGGTCTTCC
CCACCGCAGGAGCTGGCACAGATCTACGTTCCAATTATCTTCTTAATACTACAATCGCTG
GTGTGGAGGAGGCAGATGTTGTCCTTCTAGTTGGTACAAATCCACGTTTTGAGGCACCGC
TATTTAATGCTAGAATTCGAAAGAGCTGGCTTCATAATGACTTAAAAGTGGCCCTTATAG
GCAGCCCAGTGGATCTCACTTACAGATATGACCATCTGGGAGATTCTCCCAAAATTCTTC
AAGACATTGCTTCGGGTAGCCATCCATTCAGCCAGGTCCTACAGGAAGCTAAAAAACCAA
TGGTGATTTTAGGCAGTTCTGCACTCCAAAGAAATGATGGTGCAGCAATTCTTGCAGCTG
TTTCCAACATTGCTCAGAAGATTCGGACAAGTAGTGGTGTTACTGGTGATTGGAAAGTTA
TGAATATCCTTCATAGGATTGCAAGCCAAGTAGCTGCTTTGGATCTTGGCTATAAGCCTG
GGGTGGAAGCAATTCAGAAGAATCCTCCTAAAATGCTGTTTCTCCTGGGAGCAGATGGAG
GTTGTATCACTCGACAGGATTTGCCAAAGGATTGTTTCATTGTTTATCAAGGACATCATG
GCGACGTCGGAGCTCCTATAGCTGATGTTATTCTCCCTGGCGCTGCTTACACAGAGAAGT
CTGCTACTTACGTCAATACCGAGGGCCGAGCTCAGCAGACAAAAGTAGCAGTGACGCCTC
CCGGCTTGGCAAGAGAAGACTGGAAAATTATAAGAGCCCTTTCTGAGATTGCAGGTATGA
CTCTTCCATATGATACTCTGGATCAAGTGAGAAACAGATTGGAAGAAGTCTCTCCTAATC
TTGTTCGATATGATGATGTTGAAGGAGCTAATTATTTCCAGCAAGCAAGTGAGCTTTCCA
AGCTAGTGAACCAACAGCTTCTTGCTGATCCACTTGTTCCACCTCAGCTAACAATAAAAG
ACTTCTACATGACAGATTCAATTAGCAGAGCCTCACAGACAATGGCTAAATGTGTCAAAG
CTGTTACAGAGGGTGCCCATGCAG
|
| Protein Properties |
|---|
| Number of Residues
| 727 |
| Molecular Weight
| 79442.0 |
| Theoretical pI
| 6.03 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 1-21
- 25-45
- 47-67
- 88-108
- 149-169
|
| Protein Sequence
|
>NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
MLRIPVRKALVGLSKSSKGCVRTTATAASNLIEVFVDGQSVMVEPGTTVLQACEKVGMQI
PRFCYHERLSVAGNCRMCLVEIEKAPKVVAACAMPVMKGWNILTNSEKTKKAREGVMEFL
LANHPLDCPICDQGGECDLQDQSMMFGSDRSRFLEGKRAVEDKNIGPLVKTIMTRCIQCT
RCIRFASEIAGVDDLGTTGRGNDMQVGTYIEKMFMSELSGNIIDICPVGALTSKPYAFTA
RPWETRKTESIDVMDAVGSNIVVSTRTGEVMRILPRMHEDINEEWISDKTRFAYDGLKRQ
RLTEPMVRNEKGLLTHTTWEDALSRVAGMLQSFQGNDVAAIAGGLVDAEALIALKDLLNR
VDSDTLCTEEVFPTAGAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPLFNARIRK
SWLHNDLKVALIGSPVDLTYRYDHLGDSPKILQDIASGSHPFSQVLQEAKKPMVILGSSA
LQRNDGAAILAAVSNIAQKIRTSSGVTGDWKVMNILHRIASQVAALDLGYKPGVEAIQKN
PPKMLFLLGADGGCITRQDLPKDCFIVYQGHHGDVGAPIADVILPGAAYTEKSATYVNTE
GRAQQTKVAVTPPGLAREDWKIIRALSEIAGMTLPYDTLDQVRNRLEEVSPNLVRYDDVE
GANYFQQASELSKLVNQQLLADPLVPPQLTIKDFYMTDSISRASQTMAKCVKAVTEGAHA
VEEPSIC
|
| External Links |
|---|
| GenBank ID Protein
| AAA30662.1 |
| UniProtKB/Swiss-Prot ID
| P15690 |
| UniProtKB/Swiss-Prot Entry Name
| NDUS1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| J02877 |
| GeneCard ID
| NDUFS1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
