| Identification |
|---|
| BMDB Protein ID
| BMDBP00353 |
| Secondary Accession Numbers
| None |
| Name
| Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 |
| Synonyms
|
Not Available
|
| Gene Name
| PPIP5K1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in acid phosphatase activity |
| Specific Function
| Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress. |
| Pathways
|
- Inositol Phosphate Metabolism
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 21 |
| Locus
| Not Available |
| SNPs
| PPIP5K1 |
| Gene Sequence
|
>4434 bp
ATGTGGTCACTGCCGGCCAGTGAGGGCGAGAGTGCCACAGCCCACTTCTTCCTCGGAGCT
GGAGATGAGGGGCTGGGCACCCGTGGACTCGGCATGAGGCCAGAAGAGAGTGACAGCGAG
CTCCTTGAGGATGAGGAGGATGAAGTGCCTCCTGAACCTCAGATCATTGTTGGCATCTGT
GCCATGACCAAGAAATCCAAGTCCAAGCCAATGACCCAGATCCTAGAGCGACTCTGCAGG
TTTGACTACCTGACTGTTATCATCCTGGGAGAAGACGTGATCCTCAATGAACCTGTGGAA
AACTGGCCATCCTGCCACTGCCTCATCTCCTTCCACTCCAAAGGCTTTCCCCTGGACAAA
GCTGTTGCTTACTCCAAGCTTCGAAACCCTTTTCTTATCAATGACCTGGCTATGCAGTAT
TACATCCAGGATAGGAGGGAGGTGTACCGGATCCTGCAGGAGGAGGGTATTGACCTGCCT
CGATACGCTGTGCTCAACCGTGACCCTGCCCGGCCTGAGGAGTGCAACCTGATAGAGGGT
GAAGACCAGGTGGAGGTAAATGGAGCCGTCTTCCCCAAGCCCTTTGTGGAGAAGCCCGTG
AGTGCAGAGGACCACAACGTTTACATCTACTACCCCAGCTCAGCTGGAGGAGGAAGCCAG
CGCCTCTTCCGTAAGATTGGCAGCCGAAGCAGTGTTTACTCTCCAGAGAGCAGCGTCCGA
AAGACAGGCTCATACATCTATGAGGAGTTTATGCCAACAGATGGCACAGATGTCAAGGTG
TACACAGTGGGGCCAGACTATGCCCATGCTGAAGCCAGAAAATCTCCAGCTTTGGATGGG
AAGGTTGAACGAGACAGTGAGGGAAAAGAGATTCGATATCCAGTCATGCTGACCGCCATG
GAAAAGCTGGTGGCCAGGAAAGTCTGCGTAGCTTTTAAGCAAACAGTTTGTGGTTTTGAT
CTCCTCCGTGCCAATGGTCACTCCTTTGTGTGTGATGTCAATGGCTTCAGTTTTGTCAAG
AATTCAATGAAATACTATGATGATTGTGCCAAGATTCTAGGGAACACCATAATGCGGGAG
CTTGCCCCACAGTTCCAGATCCCGTGGTCCATCCCCATGGAGGCTGAGGACATTCCCATT
GTCCCTACCACTTCTGGCACTATGATGGAACTTCGTTGTGTCATTGCAATCATTCGTCAT
GGGGATCGTACACCCAAGCAGAAGATGAAGATGGAGGTGACACACCCAAGATTTTTTAGT
CTATTCGAAAAACATGGTGGTTACAAGACAGGGAAATTAAAACTGAAGCGGCCAGAGCAG
CTACAGGAGGTGCTGGACATCACACGGCTGCTATTGGCTGAACTGGAGAAAGAACCAGGT
GGTGAGATCGAGGAGAAGACGGGGAAATTGGAGCAGTTAAAATCTGTGCTGGAGATGTAC
GGTCACTTCTCAGGCATCAACCGGAAGGTGCAGCTGACTTACTACCCTCATGGAGTAAAA
GCTTCTAATGAGGGGCAAGATACACAGCGGGAGGCCCTGGCCCCATCCCTCTTGCTGGTA
CTGAAGTGGGGTGGAGAACTGACCCCGGCTGGCCGTGTTCAGGCTGAGGAACTGGGGCGA
GCTTTCCGCTGCATGTACCCTGGAGGACAGGGTGACTATGCTGGCTTTCCTGGCTGTGGG
CTGCTTCGTCTCCATAGCACTTTCCGCCACGATCTCAAGATTTACGCCTCTGATGAGGGC
CGTGTCCAGATGACTGCCGCAGCCTTTGCTAAGGGCCTTCTGGCTCTAGAAGGGGAGTTG
ACACCCATTTTGGTACAAATGGTGAAGAGTGCCAACATGAACGGGCTCTTGGACAGCGAT
GGGGATTCCCTGAGCAGCTGCCAGCACCGTGTGAAGGCTCGGCTACATCACATTCTGCAG
CAGGATGCGCCCTTTGGCCCTGAGGATTACAATCAGCTGGCTCCCACTGGAAGCACTTCC
CTCCTCAGCTCCATGGCTGTTATCCAGAATCCTGTGAAGGTCTGTGATCAAGTATTTGAC
CTGATTGAAAACCTCACTCACCAGATCCGGGAACGGATGCAGGACCCCAAGTCTGTAGAC
CTGCAGCTCTACCACAGCGAGACACTAGAGCTGATGCTGCAGCGTTGGAGCAAGCTGGAG
CGTGACTTCCGGCAGAAGAGTGGGCGCTATGACATCAGTAAGATCCCTGACATCTACGAC
TGTGTCAAGTATGATGTACAGCACAATGGGAGTCTGGGACTTCAAGGCACAGCAGAGCTG
CTCCGTCTCTCTAAGGCGCTGGCTGATGTAGTCATTCCCCAGGAATATGGGATCAGCCGG
GAGGAGAAACTGGAAATTGCCGTGGGCTTCTGTCTCCCACTGTTGCGGAAGATACTGCTT
GACCTGCAGAGAACCCACGAGGATGAGTCTGTCAACAAGCTGCATCCCCTGTACTCCCGA
GGGGTGCTCTCTCCAGGCCGCCATGTTCGAACACGTCTCTACTTCACCAGTGAGAGCCAC
GTGCACTCCCTACTGAGTGTCTTCCGCTATGGGGGACTTCTGGATGAAACCAAGGATACA
CAGTGGCAGCGAGCTTTGGCATATCTCAGTGCCATCTCAGAGCTCAACTACATGACCCAG
ATTGTCATCATGCTCTATGAGGACAACACCCGGGATCCCTTGTCGGAGGAGCGGTTCCAT
GTTGAATTGCACTTCAGCCCTGGAGTGAAAGGTGTCGAGGAAGAAGGCAGTGCCCCCACT
GGCTGTGGATTCCGTCCAGCCTCTTCTGAGAATGAGGAGAGGAAAGCAGACCAAGGCAGC
GTGGAGGACCTGTGCCCTGGGAAGGCATCAGATGAACCAGACAGAGCATTGCAGACCTCG
CCTCTGCCCTCTGAGGGCCCCGGCCTCCCAAAGAGATCACCCCTCATTCGTAACCGCAAA
GCCGGCTCCATGGAGGTGCTTTCTGAGACCTCCTCCTCGAGGCCTGGTGGGCACCGACTC
TTCTCATCTTCACGGCCACCGACAGAGATGAAGCAGAGCGGCCTAGGCTCACAGTGCACG
GGGCTGTTCAGCACGACAGTGCTGGGTGGCTCCTCCAGCGCCCCGAATCTTCAGGACTAC
GCCCGCAGCCAAGGCAAAAAGCTTCCACCCGCCAGTCTGAAGCACCGAGATGAGCTCTTG
TTTGTCCCGGCCGTAAAACGATTTTCTGTGTCGTTTGCAAAGCATCCGACTAACGGATTT
GAGGGGTGCTCCATGGTGCCTACTATTTACCCCCTGGAAACACTGCATAATGCCCTTTCC
TTGCGTCAAGTGAGTGAATTCTTGAGTAGAGTCTGCCAACGCCACACTGAGGCCCAAGCA
CAGGCGTCTGCAGCTCTCTTTGACTCTATGCACAGCAACCAAGCCTCTGACAGCCCGTTT
TCTCCACCTCGCACTCTTCATTCACCTACCCTACAACTCCAACAGCGCTCTGAAAAGCCC
CCTTGGTACAGCAGTGGCCCTTCCAGCACTGTGTCCAGTGCTGGTCCTTCCTCCCCTACT
GCAGTGGATGGTAACTGCCCTTTTGGCTTCAGTGATCAGCCCTCCGTAAGCTCACATGTG
ACTGAAGAATATCAAGGCCTTGGGCTGCTCCAGGAGGCCCCTGGGAGTGGCGCACAAGAG
CCCCCTTTAGAAGGGCAGCAAGAGCCTTTTGAACAAAACCAGTCCCCACAGGAACCACCT
GTGGAAACCAAGAAGCCGTGCCAGGAAGTTGCTGAGGAGGTCAGCCAACCATGCCAGGAC
ATCCCTGAAGAGGTCAACCAGCCATGCCAGCAGGTCTCTGACATCTGCCAGCCATGCGAG
GAGAACCATGATGATGTTGACCAGACATGCCAGGAGGTCCCTCAAATCAGCCAACCATGC
GAGGATGCCAGCCAGCTGTACCAGAAAGTCTCCAAGGAAGTTTGTGAACTTTGCCAGAAC
TCTGAGGAGGTCAACCAGCCATGCCAGGGGGTCCCTGTAGAGATTGGCAGGCTGGTCCAT
GGGTTCCCTGTAGGGGTTGGTGGCCTGGCCCAGGAAGTCCTTGGGGAAGTTGGCAGGCCC
ACCCAAGAGATCCCTGAGGAGCTCAGCCAATCGTGCCAGGAATTCTCTGTGGACATTGGC
AGGCTGGCCCAAGAGGCTTCTGCAATCAATTTGTTGTCTCCGGACACACCTGAGGTTGAT
AACCCTCCCTTAGAGTTCCCTGGGGAGGGTGCTCTGCAGGCCCAGGAGGTCTCAGAGTGG
GTGAAGCAGCAGCAGTCCTATGTGGTCCCTGAGCTGATTGACCAGCTGTCCAGAGAGGAA
GTTCCCCAAGTCCAGTGTCCACCTAGCAATGCAAACCCTCAGAGCCAGTCTCTAGCCCCT
GACCAGAACGCCCCCCTTCCACCAGCAACATGTGACTCATCATTTTCTCATTAG
|
| Protein Properties |
|---|
| Number of Residues
| 1477 |
| Molecular Weight
| 163665.0 |
| Theoretical pI
| 4.9 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 6-27
- 39-58
- 84-105
- 117-134
- 140-160
- 172-191
- 211-233
- 245-266
- 272-294
- 301-319
- 325-347
- 368-386
- 406-432
- 453-472
- 484-502
- 586-604
|
| Protein Sequence
|
>Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
MWSLPASEGESATAHFFLGAGDEGLGTRGLGMRPEESDSELLEDEEDEVPPEPQIIVGIC
AMTKKSKSKPMTQILERLCRFDYLTVIILGEDVILNEPVENWPSCHCLISFHSKGFPLDK
AVAYSKLRNPFLINDLAMQYYIQDRREVYRILQEEGIDLPRYAVLNRDPARPEECNLIEG
EDQVEVNGAVFPKPFVEKPVSAEDHNVYIYYPSSAGGGSQRLFRKIGSRSSVYSPESSVR
KTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEIRYPVMLTAM
EKLVARKVCVAFKQTVCGFDLLRANGHSFVCDVNGFSFVKNSMKYYDDCAKILGNTIMRE
LAPQFQIPWSIPMEAEDIPIVPTTSGTMMELRCVIAIIRHGDRTPKQKMKMEVTHPRFFS
LFEKHGGYKTGKLKLKRPEQLQEVLDITRLLLAELEKEPGGEIEEKTGKLEQLKSVLEMY
GHFSGINRKVQLTYYPHGVKASNEGQDTQREALAPSLLLVLKWGGELTPAGRVQAEELGR
AFRCMYPGGQGDYAGFPGCGLLRLHSTFRHDLKIYASDEGRVQMTAAAFAKGLLALEGEL
TPILVQMVKSANMNGLLDSDGDSLSSCQHRVKARLHHILQQDAPFGPEDYNQLAPTGSTS
LLSSMAVIQNPVKVCDQVFDLIENLTHQIRERMQDPKSVDLQLYHSETLELMLQRWSKLE
RDFRQKSGRYDISKIPDIYDCVKYDVQHNGSLGLQGTAELLRLSKALADVVIPQEYGISR
EEKLEIAVGFCLPLLRKILLDLQRTHEDESVNKLHPLYSRGVLSPGRHVRTRLYFTSESH
VHSLLSVFRYGGLLDETKDTQWQRALAYLSAISELNYMTQIVIMLYEDNTRDPLSEERFH
VELHFSPGVKGVEEEGSAPTGCGFRPASSENEERKADQGSVEDLCPGKASDEPDRALQTS
PLPSEGPGLPKRSPLIRNRKAGSMEVLSETSSSRPGGHRLFSSSRPPTEMKQSGLGSQCT
GLFSTTVLGGSSSAPNLQDYARSQGKKLPPASLKHRDELLFVPAVKRFSVSFAKHPTNGF
EGCSMVPTIYPLETLHNALSLRQVSEFLSRVCQRHTEAQAQASAALFDSMHSNQASDSPF
SPPRTLHSPTLQLQQRSEKPPWYSSGPSSTVSSAGPSSPTAVDGNCPFGFSDQPSVSSHV
TEEYQGLGLLQEAPGSGAQEPPLEGQQEPFEQNQSPQEPPVETKKPCQEVAEEVSQPCQD
IPEEVNQPCQQVSDICQPCEENHDDVDQTCQEVPQISQPCEDASQLYQKVSKEVCELCQN
SEEVNQPCQGVPVEIGRLVHGFPVGVGGLAQEVLGEVGRPTQEIPEELSQSCQEFSVDIG
RLAQEASAINLLSPDTPEVDNPPLEFPGEGALQAQEVSEWVKQQQSYVVPELIDQLSREE
VPQVQCPPSNANPQSQSLAPDQNAPLPPATCDSSFSH
|
| External Links |
|---|
| GenBank ID Protein
| AAI53249.1 |
| UniProtKB/Swiss-Prot ID
| A7Z050 |
| UniProtKB/Swiss-Prot Entry Name
| VIP1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC153248 |
| GeneCard ID
| PPIP5K1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
