| Identification |
|---|
| BMDB Protein ID
| BMDBP00354 |
| Secondary Accession Numbers
| |
| Name
| Vitamin K epoxide reductase complex subunit 1 |
| Synonyms
|
Not Available
|
| Gene Name
| VKORC1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in vitamin-K-epoxide reductase (warfarin-sensi |
| Specific Function
| Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 25 |
| Locus
| Not Available |
| SNPs
| VKORC1 |
| Gene Sequence
|
>492 bp
ATGGGCGCTACCTGGCGGAGTCCGGGGTGGGTGCGGCTCGCGCTCTGCCTCGCGGGTTTA
GTGCTCTCTCTCTACGCGCTGCACGTGAAGGCGGCGCGCGCCCGGGACCGGGATTACCGC
GCGCTCTGCGACGTGGGCACTGCCATCAGCTGTTCGCGCGTCTTCTCCTCCAGGTGGGGC
CGTGGCTTCGGACTGGTGGAACACGTGCTGGGCAAAGACAGCATCCTCAATCAATCCAAC
AGCATATTTGGTTGCATCTTCTACACACTGCAGTTGTTGTTAGGCTGCCTGCAGGGCCGC
TGGGCATCTGTTCTACTGAGGTTGAGTTGCTTGGTGTCTCTAGCTGGTTCTGTGTACCTG
GCCTGGATCCTGTTCTTCGTGCTCTATGATTTCTGCATCGTTTGCATCACTACTTATGCC
ATCAATGTGGGCCTGACGGTGCTCAGTTTCCGGGAGGTCCAGGGACCCCAGGGCAAGGTC
AAGGGGCACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 163 |
| Molecular Weight
| 17967.0 |
| Theoretical pI
| 9.37 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 9-29
- 82-102
- 104-122
- 128-150
|
| Protein Sequence
|
>Vitamin K epoxide reductase complex subunit 1
MGATWRSPGWVRLALCLAGLVLSLYALHVKAARARDRDYRALCDVGTAISCSRVFSSRWG
RGFGLVEHVLGKDSILNQSNSIFGCIFYTLQLLLGCLQGRWASVLLRLSCLVSLAGSVYL
AWILFFVLYDFCIVCITTYAINVGLTVLSFREVQGPQGKVKGH
|
| External Links |
|---|
| GenBank ID Protein
| AAT85856.1 |
| UniProtKB/Swiss-Prot ID
| Q6B4J2 |
| UniProtKB/Swiss-Prot Entry Name
| VKOR1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AY682746 |
| GeneCard ID
| VKORC1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
