| Identification |
|---|
| BMDB Protein ID
| BMDBP00367 |
| Secondary Accession Numbers
| None |
| Name
| Acyl-CoA synthetase short-chain family member 3, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| ACSS3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Lipid transport and metabolism |
| Specific Function
| Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (By similarity). Propionate is the preferred substrate but can also utilize acetate and butyrate with a much lower affinity. |
| Pathways
|
- Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids
- Propanoate Metabolism
|
| Reactions
|
| Propinol adenylate + Adenosine triphosphate + Pantetheine → Propionyl-CoA + Adenosine monophosphate + Pyrophosphate |
details
|
| Propinol adenylate → Propionic acid + Adenosine monophosphate |
details
|
| Caproic acid + Adenosine triphosphate + Coenzyme A → Hexanoyl-CoA + Adenosine monophosphate + Pyrophosphate |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| Not Available |
| SNPs
| ACSS3 |
| Gene Sequence
|
>2061 bp
ATGAAGCCGTCTTGGCTGCAGTGTCGCAAAGTCACCGGCGCGGGGGGCCTCGGCGGGTCC
CTGCCCGCGTCCTCTCCCGCGCGCGGAGCCGGCCCGGCCCGCCGGGCGTACGTGGCCCCC
GGCCCGCGGGGCGCTCTCGGGGGCCGGGGCTGCAGGGCGCTGTCCTCGGGCGGCGGCGAG
TACAAGACCCACTTCGCGGCCTCGGTGACCGACCCCGAGAGGTTCTGGGGCAAAGCCGCG
GAGCAGATCAGCTGGTACAAGCCCTGGACCAAGACGCTGGAGAACAGACATTCGCCTTCC
ACCAGTTGGTTTGTGGAAGGGATGCTGAACATTTGTTACAATGCCATCGATCGTCATATT
GAAAATGGTAAAGGAGATAAGATTGCTATCATTTATGACAGTCCTGTTACAAACACTAAA
GCCACTATTACCTATAAAGAAGTCCTGGAACAGGTCTCTAAGCTGGCTGGTGTTTTGGTC
AAGCATGGTGTCAAGAAGGGTGACACCGTGGTTATCTACATGCCCATGATCCCACAGGCG
ATGTACGCCATGCTGGCGTGTGCCAGGATAGGAGCCATCCACAGTCTCATATTTGGGGGA
TTTGCATCCAAAGAACTAAGCACTCGCATTGATCATGCAAAGCCCAAGCTGGTTATTACA
GCATCATTTGGCATTGAACCTGGAAGGAAGGTAGAGTACGTACCACTCGTAGAAGAGGCA
CTGAGAATAGGACAACACAAGCCAGATAAAGTTCTCATCTATAATCGTCCACATACGGAT
ATGGTTCCCTTGGCTCCAGGTTATTATCTTGATTGGGATGAAGAGCTCTCAAAAGCACAG
TCACATGATTGTGTTCCCGTTCTTTCTGAACATCCGCTGTATATCCTTTACACATCTGGA
ACGACGGGGTTGCCAAAGGGTGTGGTGAGGCCCACTGGAGGATACGCTGTAATGCTTAAC
TGGTCGATGTCTTCCATATATGGACTTAAACCTGGAGAGGTGTGGTGGGCAGCTTCTGAC
TTAGGCTGGGTTGTCGGACATTCCTATATCTGTTACGGACCTCTTCTACATGGAAATACT
ACAGTTTTATATGAGGGGAAGCCTGTGGGGACACCAGATGCTGGTGCCTATTTCCGTGTG
CTCGCGGAGCATGGAGTGGCTGCCTTGTTTACAGCGCCGACTGCAATTAGAGCGATCCGT
CAACAGGACCCTGGGGCAGCCTTGGGGAAGCAGTACTCGCTGACAAGGTTCAAAACACTG
TTTGTGGCTGGAGAACGATGTGATGTGGAGACGCTGGAATGGTCCAAAAAGGTCTTCAGA
GTGCCTGTGCTAGACCACTGGTGGCAAACTGAGACTGGATCCCCAATTACAGCATCTTGC
ATTGGATTAGGTAATTCTAAAACACCTCCTCCAGGGCAAGCAGGAAAAAGTGTTCCAGGA
TACAATGTTATGATTTTGGATGACAACATGCAAAAACTGAAGGCTCGGTGTTTAGGAAAC
ATCGTGGTAAAGTTGCCATTACCACCTGGAGCTTTTTCAGGACTCTGGAAGAATCAAGAG
GCATTCAAGCATTTATACTTTGAAAAATTTCCTGGATACTATGACACCATGGATGCTGGG
TACATGGATGAAGAAGGCTATGTTTATGTTATGTCTCGAGTTGATGACGTGATAAATGTT
GCAGGTCACAGGATTTCTGCAGGTGCCCTTGAGGAGTCTATCCTTTCCCTTGGCATTGTG
GCTGACTGTGCTGTTGTTGGGAAGGAAGATTCTTTGAAAGGTCATATCCCATTAGCCCTC
TGCGTGTTGAAAAAAGATATAAATACAACAGAGGAACACGTTTTAGAAGAAATTGTGAAA
CACGTTAGACAGACCATTGGCCCTGTGGCTGCTTTTCGGAAAGCGGTGTTTGTCAAACAG
TTACCCAAAACCAGATCTGGCAAAATTCCCCGCTCAACGCTGTCTGCCCTTGTCAATGGC
AAGCCATATAAGGTGTCTCCTACAATTGAAGATCCTGGAATTTTTGAGCACATAGAAGCC
ATGTTGAAGCAGGCATCATGA
|
| Protein Properties |
|---|
| Number of Residues
| 686 |
| Molecular Weight
| 74805.0 |
| Theoretical pI
| 9.09 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Acyl-CoA synthetase short-chain family member 3, mitochondrial
MKPSWLQCRKVTGAGGLGGSLPASSPARGAGPARRAYVAPGPRGALGGRGCRALSSGGGE
YKTHFAASVTDPERFWGKAAEQISWYKPWTKTLENRHSPSTSWFVEGMLNICYNAIDRHI
ENGKGDKIAIIYDSPVTNTKATITYKEVLEQVSKLAGVLVKHGVKKGDTVVIYMPMIPQA
MYAMLACARIGAIHSLIFGGFASKELSTRIDHAKPKLVITASFGIEPGRKVEYVPLVEEA
LRIGQHKPDKVLIYNRPHTDMVPLAPGYYLDWDEELSKAQSHDCVPVLSEHPLYILYTSG
TTGLPKGVVRPTGGYAVMLNWSMSSIYGLKPGEVWWAASDLGWVVGHSYICYGPLLHGNT
TVLYEGKPVGTPDAGAYFRVLAEHGVAALFTAPTAIRAIRQQDPGAALGKQYSLTRFKTL
FVAGERCDVETLEWSKKVFRVPVLDHWWQTETGSPITASCIGLGNSKTPPPGQAGKSVPG
YNVMILDDNMQKLKARCLGNIVVKLPLPPGAFSGLWKNQEAFKHLYFEKFPGYYDTMDAG
YMDEEGYVYVMSRVDDVINVAGHRISAGALEESILSLGIVADCAVVGKEDSLKGHIPLAL
CVLKKDINTTEEHVLEEIVKHVRQTIGPVAAFRKAVFVKQLPKTRSGKIPRSTLSALVNG
KPYKVSPTIEDPGIFEHIEAMLKQAS
|
| External Links |
|---|
| GenBank ID Protein
| AAI51333.1 |
| UniProtKB/Swiss-Prot ID
| A7MB45 |
| UniProtKB/Swiss-Prot Entry Name
| ACSS3_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC151332 |
| GeneCard ID
| ACSS3 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
