| Identification |
|---|
| BMDB Protein ID
| BMDBP00377 |
| Secondary Accession Numbers
| None |
| Name
| Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 |
| Synonyms
|
Not Available
|
| Gene Name
| NDST2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in [heparan sulfate]-glucosamine N-sulfotransf |
| Specific Function
| Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). |
| Pathways
|
- Glycan metabolism
- Heparan sulfate biosynthesis.
- Heparin biosynthesis
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 28 |
| Locus
| Not Available |
| SNPs
| NDST2 |
| Gene Sequence
|
>2655 bp
ATGCTCAAGCTGTGGAAGGTGGTACGCCCAGCTCGGCAGTTGGAACTGCACCGCCTCATA
CTGCTGCTGATTGCTTTCAGTCTGGGCTCCATGGGCTTCTTGGCTTACTACGTATCCACC
AGCCCCAAGGCCAAGGAACCGTTGCCVCTCCCCTTGGGAGACTGCAGCAGTAGTGGCGCA
GCGGGTGGTCCTGGCCCGGTTCGGCCTCCAGTCCCACCACGCCCCCCCAGGCCTCCAGAG
ACAGCGCGAACTGAACCCGTGGTCCTTGTGTTTGTGGAGAGTGCATACTCGCAGCTGGGG
CAGGAGATCGTGGCCATCTTGGAGTCTAGCCGTTTTCGTTACAGCACTGAGCTGGCACCT
GGCCGAGGGGACATGCCCACACTGACGGATCATACCCGGGGCCGGTATGTCTTGGTCATT
TATGAGAACCTGCTCAAGTACGTCAACCTGGATGCCTGGAGTCGGGAACTGCTAGACCGG
TACTGTGTGGAGTACGGTGTAGGCATCATTGGCTTTTTTCGAGCCCATGAGCACAGCCTA
CTGAGTGCCCAGCTCAAGGGCTTTCCCCTTTTTCTCCATTCAAACTTGGGGCTTCGGGAC
TACCAAGTGAATCCTACAGCTCCACTCCTACATCTCACACGTCCCAGCCGCCTGGAGCCT
GGGCCACTACCCGGTGATGACTGGACCATCTTCCAATCCAACCACAGGACCTATGAACCA
GTGCTTCTTGGCAGCCTTCGGCCGGCTGAGCCCCCTGTGCCAGGACCAGTGGCTCGGCGG
GCCCGGCTTCCCACTGTGGTGCAGGACCTGGGGGTTCACGATGGAATCCAGAGGGTGCTG
TTTGGGCACGGGCTCTCCTTCTGGCTCCACAAACTAGTTTTCCGCGATGCCGGTGGGTAC
CTCACTGGCAAGGGGCTCTTGTGGGACTTGGACCGTTACATCTTGGTAGACATCGATGAC
ATCTTTGTGGGCAAGGAAGGTACCCGCATGAAGGTGGCTGATGTTGAGGCCCTGTTGACC
ACGCAGAACAAACTCAGGACCTTAGTCCCCAACTTCACCTTCAACTTGGGCTTCTCGGGC
AAGTTCTATCATACTGGGACAGAGGAGGAGGATGCTGGGGACGACATGCTGCTGAATCAC
CGCCGAGAGTTCTGGTGGTTCCCCCACATGTGGAGCCACATGCAGCCACATCTGTTCCAC
AATCGCTCCGTGCTGGCTGACCAGATGAGGCTCAACAAACAGTTTGCTCTGGAACATGGG
ATTCCCACGGATCTGGGGTATGCTGTGGCCCCCCACCACTCCGGCGTGTACCCCATCCAC
ACACAGCTCTATGAAGCCTGGAAATCTGTGTGGGGCATCCAGGTGACCAGCACTGAGGAG
TACCCCCACCTCCGCCCTGCCCGCTACCGCCGCGGCTTCATTCACAATGGCATTATGGTG
CTGCCGCGGCAGACATGTGGCCTCTTCACTCACACAATCTTCTATAATGAGTATCCAGGA
GGCTCTCGTGAACTCGACCGGAGTATCCGAGGTGGAGAACTCTTTCTGACAGTGCTGCTT
AATCCGATCAGCATCTTTATGACTCATCTGTCGAACTATGGAAATGATCGCCTGGGTCTG
TACACCTTTGAGAGCCTGGTGCGCTTTCTCCAGTGCTGGACGAGCCTGCGCCTACAGACC
CTTCCTCCTGTCCCTCTTGGGCGAAAGTACTTTGACCTCTTCCCTCAAGAGCGAAGCCCC
CTTTGGCAGAATCCCTGTGACGACAAGAGGCACAAAGATATCTGGTCCAAGGAGAAAACC
TGTGATCGCCTCCCCAAGTTCCTCATTGTGGGACCCCAGAAGACAGGGACCACAGCTATT
CACTTCTTCCTGAGCCTGCATCCAGCTGTGACTAGCAGTTTTCCTAGCCCCAGCACCTTT
GAGGAGATTCAGTTCTTCAACGGCCCTAATTACCACAAGGGCATTGACTGGTACATGGAT
TTCTTCCCTGTCCCTTCCAATGCCAGCACTGATTTCCTATTTGAAAAAAGTGCCACGTAC
TTTGACTCAGAGGTTGTACCACGGCGGGGAGCTGCCCTCCTGCCACGAGCCAAGATCATC
ACTGTGCTCACCAACCCTGCTGACAGGGCATACTCCTGGTACCAGCATCAGCGAGCACAT
GGAGACCCAGTTGCTCTGAACTACACCTTCTACCAGGTGATTACAGCCTCCTCCCAGGAC
CCTCCAGCACTTCGCTCCCTACAAAACCGTTGTCTTGTCCCCGGCTACTATTCCACTCAC
TTACAACGCTGGCTGACTTACTACCCCTCTGGACAGTTGCTGATTGTGGATGGGCAAGAG
CTGCGTACCAACCCAGCTGCCTCAATGGAGATCATCCAGAAGTTCCTGGGTATCACACCC
TTTCTGAACTACACACGGACCCTCAGGTTCGATGAAGATAAGGGATTCTGGTGCCAGGGA
CTTGAAGGTGGCAAGACTCGTTGTCTAGGAAAGAGCAAAGGTCGGAAGTACCCAGATATG
GACGCTGAGTCCCGCCTTTTCCTTACGGATTTTTTCCGGAACCACAATTTGGAGCTGTCA
AAGCTGCTGAGCCGGCTTGGACAGCCAGTGCCCTCATGGCTTCGAGAAGAACTGCAGCAT
TCCAGTTCGGGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 884 |
| Molecular Weight
| 100897.0 |
| Theoretical pI
| 8.94 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2
MLKLWKVVRPARQLELHRLILLLIAFSLGSMGFLAYYVSTSPKAKEPLPLPLGDCSSSGA
AGGPGPVRPPVPPRPPRPPETARTEPVVLVFVESAYSQLGQEIVAILESSRFRYSTELAP
GRGDMPTLTDHTRGRYVLVIYENLLKYVNLDAWSRELLDRYCVEYGVGIIGFFRAHEHSL
LSAQLKGFPLFLHSNLGLRDYQVNPTAPLLHLTRPSRLEPGPLPGDDWTIFQSNHRTYEP
VLLGSLRPAEPPVPGPVARRARLPTVVQDLGVHDGIQRVLFGHGLSFWLHKLVFRDAGGY
LTGKGLLWDLDRYILVDIDDIFVGKEGTRMKVADVEALLTTQNKLRTLVPNFTFNLGFSG
KFYHTGTEEEDAGDDMLLNHRREFWWFPHMWSHMQPHLFHNRSVLADQMRLNKQFALEHG
IPTDLGYAVAPHHSGVYPIHTQLYEAWKSVWGIQVTSTEEYPHLRPARYRRGFIHNGIMV
LPRQTCGLFTHTIFYNEYPGGSRELDRSIRGGELFLTVLLNPISIFMTHLSNYGNDRLGL
YTFESLVRFLQCWTSLRLQTLPPVPLGRKYFDLFPQERSPLWQNPCDDKRHKDIWSKEKT
CDRLPKFLIVGPQKTGTTAIHFFLSLHPAVTSSFPSPSTFEEIQFFNGPNYHKGIDWYMD
FFPVPSNASTDFLFEKSATYFDSEVVPRRGAALLPRAKIITVLTNPADRAYSWYQHQRAH
GDPVALNYTFYQVITASSQDPPALRSLQNRCLVPGYYSTHLQRWLTYYPSGQLLIVDGQE
LRTNPAASMEIIQKFLGITPFLNYTRTLRFDEDKGFWCQGLEGGKTRCLGKSKGRKYPDM
DAESRLFLTDFFRNHNLELSKLLSRLGQPVPSWLREELQHSSSG
|
| External Links |
|---|
| GenBank ID Protein
| AAC77921.1 |
| UniProtKB/Swiss-Prot ID
| O97583 |
| UniProtKB/Swiss-Prot Entry Name
| NDST2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF064825 |
| GeneCard ID
| NDST2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
