| Identification |
|---|
| BMDB Protein ID
| BMDBP00378 |
| Secondary Accession Numbers
| None |
| Name
| Sulfotransferase 1E1 |
| Synonyms
|
Not Available
|
| Gene Name
| SULT1E1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in estrone sulfotransferase activity |
| Specific Function
| Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone (PubMed:1900200) (By similarity). Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency. Does not sulfonate cortisol, testosterone and dopamine (By similarity). |
| Pathways
|
- Androgen and Estrogen Metabolism
- Estrone Metabolism
- Sulfate/Sulfite Metabolism
|
| Reactions
|
| Estrone + Phosphoadenosine phosphosulfate → Estrone sulfate + Adenosine 3',5'-diphosphate |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 6 |
| Locus
| Not Available |
| SNPs
| SULT1E1 |
| Gene Sequence
|
>888 bp
ATGAGTTCTTCCAAACCATCCTTTTCAGATTACTTTGGCAAACTTGGTGGAATACCAATG
TATAAAAAATTTATCGAGCAGTTTCATAACGTGGAGGAATTTGAGGCAAGACCAGATGAC
CTTGTCATTGTCACCTATCCCAAATCTGGTACAACATGGCTTAGTGAAATTATATGCATG
ATTTATAATAACGGTGATGTGGAAAAGTGCAAAGAAGACGTCATTTTTAATAGAGTTCCT
TACCTGGAATGTAGCACTGAACACGTGATGAAAGGAGTGAAACAATTAAATGAGATGGCA
TCTCCTAGAATAGTGAAGTCTCACCTGCCTGTGAAGCTTCTTCCAGTCTCATTTTGGGAA
AAGAACTGTAAGATCATCTATCTTTCCCGGAATGCCAAGGATGTGGTTGTTTCTTATTAT
TTTTTAATTTTAATGGTGACTGCTATTCCAGATCCTGACTCTTTTCAAGATTTTGTGGAG
AAATTCATGGATGGAGAAGTTCCTTATGGTTCCTGGTTTGAACATACAAAATCTTGGTGG
GAAAAGAGCAAGAATCCGCAAGTGCTATTTCTTTTCTATGAAGACATGAAGGAGAATATC
AGAAAAGAGGTGATGAAATTGTTAGAATTTCTGGGAAGGAAGGCATCAGATGAGCTTGTG
GACAAGATTATAAAACACACTTCATTCCAGGAGATGAAGAACAATCCATCTACCAATTAT
ACAACATTGCCGGATGAAGTCATGAACCAAAAAGTATCTCCCTTCATGAGAAAAGGAGAT
GTAGGAGACTGGAAGAATCACTTTACAGTAGCCCTGAATGAGAAATTTGACATGCACTAT
GAGCAGCAAATGAAGGGGTCTACCCTGAAGTTCCGAACTAAGATCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 295 |
| Molecular Weight
| 34640.0 |
| Theoretical pI
| 7.18 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Estrogen sulfotransferase
MSSSKPSFSDYFGKLGGIPMYKKFIEQFHNVEEFEARPDDLVIVTYPKSGTTWLSEIICM
IYNNGDVEKCKEDVIFNRVPYLECSTEHVMKGVKQLNEMASPRIVKSHLPVKLLPVSFWE
KNCKIIYLSRNAKDVVVSYYFLILMVTAIPDPDSFQDFVEKFMDGEVPYGSWFEHTKSWW
EKSKNPQVLFLFYEDMKENIRKEVMKLLEFLGRKASDELVDKIIKHTSFQEMKNNPSTNY
TTLPDEVMNQKVSPFMRKGDVGDWKNHFTVALNEKFDMHYEQQMKGSTLKFRTKI
|
| External Links |
|---|
| GenBank ID Protein
| AAA30679.1 |
| UniProtKB/Swiss-Prot ID
| P19217 |
| UniProtKB/Swiss-Prot Entry Name
| ST1E1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| M54942 |
| GeneCard ID
| SULT1E1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
