| Identification |
|---|
| BMDB Protein ID
| BMDBP00389 |
| Secondary Accession Numbers
| |
| Name
| Phenylalanine-4-hydroxylase |
| Synonyms
|
Not Available
|
| Gene Name
| PAH |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine. |
| Pathways
|
- Acetoacetate and fumarate from L-phenylalanine: step 1/6
- Amino-acid degradation
- L-phenylalanine degradation
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| Not Available |
| SNPs
| PAH |
| Gene Sequence
|
>1356 bp
ATGTCAGCTCTGGTCCTGGAGAGCCGAGCCTTGGGCAGGAAACTCAGCGACTTTGGACAG
GAAACGAGCTATATTGAAGGCAACTCTGATCAAAATGCTGTATCGCTGATCTTCTCACTC
AAAGAAGAAGTTGGTGCACTGGCCAGAGTATTACGTTTATTTGAGGAGAATGATATAAAC
CTGACCCACATTGAATCAAGACCTTCACGTTTAAGGAAAGACGAGTATGAATTTTTCACC
AATCTGGATCAACGCAGCGTGCCTGCCCTGGCAAACATCATCAAGATCTTGAGACATGAC
ATTGGTGCCACTGTGCACGAGCTTTCCCGGGATAAGAAGAAAGACACAGTGCCCTGGTTT
CCAAGAACCATTCAGGAACTCGACAACTTTGCCAACCAGGTTCTCAGCTATGGAGCTGAA
CTGGATGCAGATCACCCGGGATTTAAAGATCCTGTATACCGAGCAAGACGGAAGCAATTC
GCTGACATTGCCTACAACTATAGACATGGGCAGCCCATTCCTCGAGTGGAATACACGGAG
GAAGAAAAAAAAACATGGGGGACGGTATTCAGGACCCTGAAGTCCTTGTATAAGACCCAT
GCTTGCTATGAGCACAACCACATTTTCCCCCTTCTGGAAAAGTATTGCGGCTTCCGTGAA
GATAACATTCCCCAGCTCGAAGAGGTTTCTCAGTTTCTGCAGAGTTGCACTGGTTTCCGC
CTCCGACCAGTCGCTGGCCTGCTTTCTTCTCGGGATTTCTTGGGTGGCCTGGCTTTCCGA
GTCTTCCACTGCACTCAGTACATCAGACATGGGTCTAAGCCCATGTATACACCAGAACCG
GACATATGCCATGAGCTCTTGGGACATGTACCTTTGTTTTCAGATCGCAGCTTTGCCCAG
TTTTCGCAGGAGATCGGCCTTGCCTCCCTGGGTGCACCTGATGAGTACATTGAAAAACTT
GCAACAATTTACTGGTTTACTGTGGAGTTTGGGCTCTGCAAGCAAGGAGACTCCATAAAG
GCATATGGTGCTGGGCTCCTGTCATCCTTTGGTGAATTACAGTATTGCCTATCAGACAAG
CCAAAGCTCCTTCCTCTGGAACTGGAGAAGACCGCTGTCCAGGAGTATACGATCACAGAG
TTCCAGCCTCTGTATTATGTGGCTGAGAGTTTTAATGATGCCAAGGAGAAAGTGAGGAAC
TTTGCTGCCACAATCCCACGGCCCTTCTCAGTTCATTATGACCCATACACTCAACGGATT
GAGGTCTTGGACAACACCCAGCAACTTAAGATTTTGGCTGACTCCATCAGTAGTGAAGTT
GAGATCCTTTGCAGTGCCCTCCAGAAATTAAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 451 |
| Molecular Weight
| 51727.0 |
| Theoretical pI
| 6.2 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Phenylalanine-4-hydroxylase
MSALVLESRALGRKLSDFGQETSYIEGNSDQNAVSLIFSLKEEVGALARVLRLFEENDIN
LTHIESRPSRLRKDEYEFFTNLDQRSVPALANIIKILRHDIGATVHELSRDKKKDTVPWF
PRTIQELDNFANQVLSYGAELDADHPGFKDPVYRARRKQFADIAYNYRHGQPIPRVEYTE
EEKKTWGTVFRTLKSLYKTHACYEHNHIFPLLEKYCGFREDNIPQLEEVSQFLQSCTGFR
LRPVAGLLSSRDFLGGLAFRVFHCTQYIRHGSKPMYTPEPDICHELLGHVPLFSDRSFAQ
FSQEIGLASLGAPDEYIEKLATIYWFTVEFGLCKQGDSIKAYGAGLLSSFGELQYCLSDK
PKLLPLELEKTAVQEYTITEFQPLYYVAESFNDAKEKVRNFAATIPRPFSVHYDPYTQRI
EVLDNTQQLKILADSISSEVEILCSALQKLK
|
| External Links |
|---|
| GenBank ID Protein
| ABQ13025.1 |
| UniProtKB/Swiss-Prot ID
| Q2KIH7 |
| UniProtKB/Swiss-Prot Entry Name
| PH4H_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BT030585 |
| GeneCard ID
| PAH |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
