| Identification |
|---|
| BMDB Protein ID
| BMDBP00395 |
| Secondary Accession Numbers
| None |
| Name
| Histone-lysine N-methyltransferase SUV39H2 |
| Synonyms
|
Not Available
|
| Gene Name
| SUV39H2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in histone-lysine N-methyltransferase activity |
| Specific Function
| Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 13 |
| Locus
| Not Available |
| SNPs
| SUV39H2 |
| Gene Sequence
|
>1233 bp
ATGGCGGCGGCCGGGGCCGAGGCGCCAGGAGCTTGGTGTGTGCCTTGCCTAGTTTCACTT
GATACTCTTCAGGAATTATGTAGAAAAGAAAAGCTCACATGTAAATCGATTGGAATCACC
AAAAGGAATCTAAACAATTATGAGGTGGAATACTTGTGTGACTACAAGGTAGTAAAGGAT
ATGGAATATTATCTTGTAAAATGGAAAGGATGGCCAGATTCTACAAATACTTGGGAACCT
TTGCAAAATCTCAAGTGCCCATTACTACTTCAGCAGTTCTTTAATGACAAGCATAATTAT
TTATCTCAGGTAAAGAAAGGCAAAGCAATAACTCTAAAAGAAAATCACAGAGCCTTGAAA
CCTGCTGTTGCTGAATACATTGTAAAGAAGGCTAAACAAAGGATAGCCCTGCAGAGATGG
CAGGATGAACTCAACAGAAGGAAGACTCACAAAGGAATGATTTTTGTTGAAAATACTGTG
GACTTAGAGGGGCCCCCTTCAGACTTCTACTACATTAATGAATACAAACCAGCTCCTGGA
ATCAGCTTAGTAAATGAAGCTACCTTTGGTTGTTCATGCACAGATTGCTTCTTTGAAAAA
TGTTGTCCTGCTGAAGCTGGAGTTCTTTTGGCTTATAATAAAAATCAACAAATTAAAATC
CCACCTGGTACCCCCATTTATGAGTGCAACTCAAGATGTCAATGTGGACCCGACTGTCCC
AACAGGATCGTACAAAAAGGCACACAGTATTCACTTTGCATCTTTCGAACTAGCAATGGC
TGTGGCTGGGGTGTAAAAACCCTTGTGAAGATTAAAAGAATGAGTTTTGTCATGGAATAT
GTTGGAGAGGTGATCACCAGTGAGGAAGCTGAGAGACGTGGCCAGTTATATGACAACAAA
GGAATCACGTATCTCTTTGATCTGGACTATGAATCTGATGAATTCACAGTGGATGCAGCT
CGATATGGAAATGTGTCTCATTTTGTGAATCACAGTTGTGACCCAAACCTTCAGGTGTTC
AATGTTTTCATTGATAACCTCGATACCCGTCTTCCCCGAATAGCATTATTTTCCACGAGA
ACTATCAATGCTGGAGAAGAGCTCACTTTTGATTATCAAATGAAAGGTTCTGGAGATGTA
TCTTCAGATTCTATTGACCACAGCCCAGCCAAAAAGAGGGCCAGAACTGTGTGCAAATGT
GGAGCTGTGACTTGCAGAGGTTACCTCAACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 410 |
| Molecular Weight
| 46551.0 |
| Theoretical pI
| 7.97 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Histone-lysine N-methyltransferase SUV39H2
MAAAGAEAPGAWCVPCLVSLDTLQELCRKEKLTCKSIGITKRNLNNYEVEYLCDYKVVKD
MEYYLVKWKGWPDSTNTWEPLQNLKCPLLLQQFFNDKHNYLSQVKKGKAITLKENHRALK
PAVAEYIVKKAKQRIALQRWQDELNRRKTHKGMIFVENTVDLEGPPSDFYYINEYKPAPG
ISLVNEATFGCSCTDCFFEKCCPAEAGVLLAYNKNQQIKIPPGTPIYECNSRCQCGPDCP
NRIVQKGTQYSLCIFRTSNGCGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQLYDNK
GITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTR
TINAGEELTFDYQMKGSGDVSSDSIDHSPAKKRARTVCKCGAVTCRGYLN
|
| External Links |
|---|
| GenBank ID Protein
| AAI08112.1 |
| UniProtKB/Swiss-Prot ID
| Q32PH7 |
| UniProtKB/Swiss-Prot Entry Name
| SUV92_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC108111 |
| GeneCard ID
| SUV39H2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
