| Identification |
|---|
| BMDB Protein ID
| BMDBP00398 |
| Secondary Accession Numbers
| None |
| Name
| N-lysine methyltransferase KMT5A |
| Synonyms
|
Not Available
|
| Gene Name
| KMT5A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in histone-lysine N-methyltransferase activity |
| Specific Function
| Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| Not Available |
| SNPs
| KMT5A |
| Gene Sequence
|
>1059 bp
ATGGCTAGAGGCAGGAAGATGTCCAAGCCCCGCGCGGTGGAGGCGGCGGCGGCGGCGGCG
GCGGTGGCAGCGACGGCCCCGGGCCCGGAGATGGTGGAGCGGAGGGGCCCGGGGAGGCCC
CGCACCAACGGGGAGAATGTATTTACCGGGCAATCAAAGATCTATACCTACATGAGCCCG
AACAAATGCTCTGGAATGCGTTCCCCCCTTCAGGAAGAGAACTCAGTTGCACAATACGAA
GTCAAATGCCAGGGGAAGCCATTAGCCGGAATCTACAGGAAACGCGACGAGAAAAGAAAC
TCTGGGAATGCAATACGAAGCTCCATGAAGGCCGAGGAACAGAAGATCAAAGACGCCAGG
AGAGGTCCCCTGGCACCTTTTCCAAACCAAAAATCTGAAGCTGCAGAACCTCCCAAAACC
CCAACCTCGTCTTGTGATACTCCCAATGCAGCCGCTGCCAAGCAGGGCCTGAAAAAGCCT
GTGAGGGGCAAACAGGCCCCCAGGAAAAAAGCTCAAGGAAAAACACAGCAGAATCGCAAG
CTCACAGATTTCTACCCTGTGCGAAGGAGCTCAAGGAAGAGCAAGGCTGAGCTGCAGTCT
GAAGAAAGGAAAAGAATAGATGAGTTGATTGAAAGCGGGAAGGAAGAAGGAATGAAGATC
GACCTCATCGACGGCAAAGGCAGGGGCGTCATCGCCACCAAGCAGTTCTCCCGGGGTGAG
TTTGTGGTGGAATACCACGGGGACCTCATCGAGATCACCGACGCCAAGAAGCGGGAGGCT
CTGTACGCACAAGACCCCTCCACGGGCTGCTACATGTACTATTTTCAGTATCTGAGCAAA
ACCTACTGCGTGGATGCAACCCGAGAGACAAATCGCCTGGGAAGACTGATCAATCACAGT
AAATGTGGGAACTGCCAAACCAAACTGCACGACATCGACGGCGTGCCTCACCTCATCCTC
ATCGCCTCCCGTGACATCGAGGCCGGGGAGGAGCTTCTGTATGACTATGGGGACCGCAGC
CGGGCTTCCATTGAAGCCTACCCCTGGCTGAAGCATTAA
|
| Protein Properties |
|---|
| Number of Residues
| 352 |
| Molecular Weight
| 39277.0 |
| Theoretical pI
| 10.1 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Histone-lysine N-methyltransferase SETD8
MARGRKMSKPRAVEAAAAAAAVAATAPGPEMVERRGPGRPRTNGENVFTGQSKIYTYMSP
NKCSGMRSPLQEENSVAQYEVKCQGKPLAGIYRKRDEKRNSGNAIRSSMKAEEQKIKDAR
RGPLAPFPNQKSEAAEPPKTPTSSCDTPNAAAAKQGLKKPVRGKQAPRKKAQGKTQQNRK
LTDFYPVRRSSRKSKAELQSEERKRIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGE
FVVEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETNRLGRLINHS
KCGNCQTKLHDIDGVPHLILIASRDIEAGEELLYDYGDRSRASIEAYPWLKH
|
| External Links |
|---|
| GenBank ID Protein
| AAI10190.1 |
| UniProtKB/Swiss-Prot ID
| Q2YDJ8 |
| UniProtKB/Swiss-Prot Entry Name
| KMT5A_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC110189 |
| GeneCard ID
| KMT5A |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
